Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Xopenex (levalbuterol) and Breo Ellipta (fluticasone/vilanterol) are both inhaled medications used to help with breathing problems, but they work differently and are used for different purposes. Xopenex is a short-acting beta agonist (SABA) that quickly opens up your airways to relieve sudden wheezing or shortness of breath, and it's typically used three times a day. In contrast, Breo Ellipta is a combination of an inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA) used for the long-term control of asthma and chronic obstructive pulmonary disease (COPD), and it's taken once daily. Xopenex is suitable for children as young as 6 years old, while Breo Ellipta can be used by children as young as 5 years old for asthma. Xopenex requires a nebulizer machine for administration, which can be less convenient, especially when traveling. Breo Ellipta, on the other hand, is a dry powder inhaler that is easier to use and doesn't require a nebulizer. You will need to rinse your mouth out with water after taking your Breo Ellipta dose to prevent oral thrush, a fungal infection in the mouth. Breo Ellipta contains lactose, so it can't be used if you're severely allergic to milk proteins. Both medications have generic versions available, making them more affordable.
Levalbuterol (Xopenex) inhalation solution
Breo ellipta (fluticasone furoate / vilanterol)
Levalbuterol (Xopenex) inhalation solution
Breo ellipta (fluticasone furoate / vilanterol)
Summary of Xopenex vs. Breo Ellipta
Summary for SABA
Prescription only
Levalbuterol inhalation solution (also known by its brand name, Xopenex) is a short-acting beta agonist (SABA). It's used to treat and prevent sudden wheezing or shortness of breath in people with certain breathing problems, such as asthma. This medication is for adults and children ages 6 years and older. Levalbuterol (Xopenex) inhalation solution is inhaled through the mouth with a nebulizer machine. Side effects of this medication include headache, sore throat, and runny nose. It's available as a lower-cost generic.
Summary for Inhaled corticosteroid / LABA
Prescription only
Breo Ellipta (fluticasone furoate / vilanterol) is a maintenance inhaler used every day to help manage asthma and chronic obstructive pulmonary disease (COPD). It's a combination of two medications: fluticasone, a corticosteroid that reduces swelling in your lungs, and vilanterol, a long-acting beta agonist (LABA) that helps relax your airways. The typical dose is one puff by mouth once a day. Breo Ellipta (fluticasone furoate / vilanterol) isn't for sudden breathing problems or asthma attacks. Side effects include oral thrush, sore throat, and headache.
Indications of Xopenex vs. Breo Ellipta
Indications for
•Treatment or prevention of wheezing or tightening of airways in people ages 6 years and older with certain types of lung problems (e.g., asthma)
Indications for
•Asthma - in adults and children 5 years and older