Dupixent Dosages: Your GoodRx Guide for Eczema, Asthma, and More

If you or your child is living with an inflammatory health condition, such as asthma or eczema, your healthcare team may prescribe Dupixent (dupilumab). It’s an injectable medication that you’ll initially receive in your prescriber’s office. After that, you or your caregiver may be able to administer Dupixent at home.

How much and how often you inject Dupixent depends on what you’re treating. For children, their age and body weight can also be a factor. Below, we cover typical Dupixent dosages for adults and children and what to do if you miss a dose.

Dupixent dosage forms

Dupixent comes in two dosage forms: a prefilled syringe and a prefilled injection pen. Both options are available in 200 mg and 300 mg doses and are stored in the refrigerator. If you remove Dupixent from the refrigerator, you must use it within 14 days (2 weeks).

How to inject Dupixent

No matter the dosage form, you’ll inject Dupixent subcutaneously (under the skin) in your stomach or thigh. If someone else is giving your injection, they can also use your upper outer arm. This area is too awkward to safely inject into on your own. You should rotate injection sites with each dose of Dupixent to avoid skin irritation.

Remove your Dupixent dose from the refrigerator about 30 to 45 minutes before injecting it to reduce discomfort. Be sure to wash your hands, then wipe the injection site with alcohol and let it dry naturally before administering the injection.

To inject Dupixent, remove the needle cover or injection pen cap, and discard. Gently pinch the clean skin area, and insert the needle at a 45-degree angle or press the pen firmly against the skin at a 90-degree angle.

• For the syringe, gently press down on the plunger until all liquid is injected. Lift your thumb from the plunger until the needle is covered by the needle shield. Remove the syringe, and discard it in a sharps container. 

• For the pen, you’ll hear a click when the injection starts, followed by a second click when it’s complete. The window will also turn yellow over the course of the injection. Once the window is fully yellow and the second click occurs, count to 5 slowly. Then pull straight up to remove the pen from your skin, and discard it in a sharps container.

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What’s the typical Dupixent dosage for adults?

The typical Dupixent dosage for adults depends on which health condition you’re treating. Oftentimes, you’ll start treatment with a higher initial dose. This is referred to as a loading dose. Then you’ll continue therapy with a lower maintenance dose.

Moderate-to-severe eczema

For moderate-to-severe eczema (atopic dermatitis), the initial Dupixent dose for adults is 600 mg, given as two 300 mg doses. After that, the maintenance dosage is 300 mg injected every other week.

Moderate-to-severe asthma

For moderate-to-severe asthma in adults, your Dupixent dosage may depend on your asthma severity and other health conditions being treated. The manufacturer recommends the following options:

• Option 1: 400 mg (given as two 200 mg doses), followed by 200 mg every other week

• Option 2: 600 mg (given as two 300 mg doses), followed by 300 mg every other week

If you need oral steroids to manage your asthma, or if you also have other health conditions managed by Dupixent, you may need the higher Dupixent dosage. Your prescriber will determine which option is appropriate for you.

Chronic rhinosinusitis with nasal polyps (CRSwNP)

For chronic rhinosinusitis with nasal polyps (CRSwNP) in adults, the typical Dupixent dosage is 300 mg injected every other week. There’s no recommended loading dose for this use.

Eosinophilic esophagitis

For eosinophilic esophagitis, the typical Dupixent dosage for adults is 300 mg injected once weekly. This is based on having a body weight of 40 kg (88 lbs) or more. If you weigh less than 40 kg, you may inject Dupixent once every other week. No loading dose is required.

EXPERT PICKS: WHAT TO READ NEXT

• Biologics for eczema: See how these biologics stack up to one another when it comes to treating eczema.

• Tolerating treatment: Read this guide to managing a number of potential Dupixent (dupilumab) side effects.

• Eczema diet: Learn more about which foods can trigger eczema symptoms — and which ones can help reduce flare-ups.

Prurigo nodularis, chronic spontaneous urticaria, and bullous pemphigoid

For prurigo nodularis, chronic spontaneous urticaria, and bullous pemphigoid (skin conditions that cause chronic hives or itchy skin bumps and blisters), the typical Dupixent dosage for adults is 600 mg, given as two 300 mg doses. This is followed by a maintenance dosage of 300 mg injected every other week.

Chronic obstructive pulmonary disease (COPD)

For chronic obstructive pulmonary disease (COPD), the recommended Dupixent dosage for adults is 300 mg injected every other week. No loading dose is required.

What’s the typical Dupixent dosage for children?

In addition to adults, Dupixent is also approved for use in children ages 6 months and older. The typical Dupixent dosage for children is based on the health condition being treated. Your child’s body weight may also be considered when determining their dosage.

Moderate-to-severe eczema

For moderate-to-severe eczema in children, the typical Dupixent dosage depends on their age and weight.

Dosage table for children ages 6 months to 5 years:

Dosage table for children ages 6 to 17 years:

Moderate-to-severe asthma

For children ages 12 and older, the typical Dupixent dosage for moderate-to-severe asthma is the same as adults. For children ages 6 to 11, the Dupixent dosage depends on their body weight.

Dosage table for children ages 6 to 11 years:

Children ages 6 to 11 receiving Dupixent for both asthma and eczema will follow the dosage schedule for eczema, which includes a loading dose.

Chronic rhinosinusitis with nasal polyps (CRSwNP)

For CRSwNP, children ages 12 and older will follow the same dosage as in adults — 300 mg injected every other week. There’s no recommended loading dose for this use.

Eosinophilic esophagitis

For eosinophilic esophagitis, the Dupixent dosage for children ages 1 year and older is based on their body weight. No loading dose is required.

Dosage table for children age 1 year and older:

Chronic spontaneous urticaria

For chronic spontaneous utricaria, Dupixent is approved for children ages 12 to 17. The dosage is based on body weight.

Dosage table for children ages 12 to 17:

What happens if you miss a dose of Dupixent?

If you miss a dose of Dupixent, the first step is to recall your last dose. What to do next depends on whether you inject the medication weekly, every other week, or every 4 weeks.

Missed weekly dose: Give yourself the Dupixent injection as soon as possible. Restart your weekly injections from the day you inject the missed dose. For example, if you miss your usual Sunday dose and inject it on Tuesday, you’ll now inject your weekly dose every Tuesday.

Missed every-other-week dose: Give the Dupixent injection as soon as you remember. If it’s within 7 days of the missed dose, you can resume your normal injection schedule. But if your dose is more than 7 days late, you’ll start a new every-other-week schedule based on the day of the injection.

Missed every-4-week dose: Give the Dupixent injection as soon as you remember. If it’s within 7 days of the missed dose, resume your normal injection schedule. But if it has been more than 7 days since the missed dose, inject Dupixent and begin injecting every 4 weeks from that date.

Your healthcare team may provide other instructions for what to do if you miss your dose, so be sure to follow their instructions. You can also ask them for guidance if you’re unsure what to do after missing a dose of Dupixent.

What should you do if you inject too much Dupixent?

Since Dupixent comes in single-dose injections, it’s unlikely that you’ll inject more than recommended. If you’re unsure when you last injected a dose, look at the fill date on the label and how many doses are left. This can help give you an idea of how many doses you’ve injected and when you’re next due for one. If you’re still unsure, contact your healthcare team for guidance.

If you inject an extra dose of Dupixent, or inject it earlier than scheduled, contact your prescriber right away. You can also contact Poison Control at 1-800-222-1222 for guidance. They’ll determine if you need additional follow-up. You may experience more side effects, such as dry eyes and joint or muscle pain. But if you have any symptoms that feel life-threatening, call 911 or go to the ER.

How to save on the cost of Dupixent

There are ways to save on Dupixent, which is available only as a reference (“brand name”) medication. GoodRx can help you navigate between copay savings cards and patient assistance programs to save money on your medication:

• Save with a copay savings card: If you have commercial insurance, you may be eligible to pay as little as $0 for your Dupixent prescriptions using a copay savings card from the manufacturer.

• Save with a patient assistance program: If you’re uninsured or underinsured, you may be eligible for Dupixent’s patient assistance program, which offers the medication free of charge.

Keep in mind that Dupixent is a specialty medication, meaning you won’t be able to pick it up at your usual pharmacy. Instead, you’ll likely receive it through a specialty pharmacy. The good news is that specialty pharmacy staff are trained to help assist you with insurance coverage and cost-savings options. So don’t hesitate to ask them for help if you’re having trouble accessing Dupixent at an affordable price.

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Written by:

Stacia Woodcock, PharmD

Stacia Woodcock, PharmD, is a pharmacy editor for GoodRx. She earned her Doctor of Pharmacy degree from the University of Kentucky and is licensed in New York and Massachusetts.

Reviewed by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

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