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Compare Tezspire vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tezspire (tezepelumab) and Dupixent (dupilumab) are both injectable biologic medications used to treat asthma, but they belong to different medication classes. Tezspire is a thymic stromal lymphopoietin (TSLP) blocker, while Dupixent is an interleukin antagonist. Tezspire is specifically approved for severe asthma in people aged 12 and older, whereas Dupixent is approved for moderate-to-severe asthma in people aged 6 and older, as well as other conditions like eczema and eosinophilic esophagitis. Tezspire is typically injected once a month by a healthcare professional, while Dupixent is usually injected every 1 to 4 weeks, depending on the condition being treated. Both medications are available as pre-filled pens and syringes. Tezspire has a low risk of side effects but can cause joint and back pain, while Dupixent can cause injection site reactions and eye inflammation. Both medications can cause serious allergic reactions and are not used to treat asthma attacks.

  • Tezspire (tezepelumab)
    Dupixent (dupilumab)
  • Tezspire (tezepelumab)
    Dupixent (dupilumab)

  • Summary of Tezspire vs. Dupixent

    Summary for TSLP blocker
    Prescription only

    Tezspire (tezepelumab or tezepelumab-ekko) is one of the available biologics for treating asthma. It's approved for people 12 years and older with severe asthma that's not controlled by other medications. Tezspire (tezepelumab) is an injection that's given under the skin once per month by a healthcare professional (HCP). There's also a prefilled pen for Tezspire (tezepelumab) that you can use at home after proper training from an HCP. Side effects aren't common but can include joint and back pain.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Tezspire vs. Dupixent

    Indications for
    •Add-on maintenance treatment for severe asthma in people ages 12 years and older
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Tezspire vs. Dupixent

    Pros and Const for TSLP blocker
    Pros
    •Works well to prevent asthma attacks from happening and to improve your breathing
    •Might work better than other asthma biologics
    •Only given once per month
    •Can use in children as young as 12 years old
    Cons
    •Given as an injection under the skin
    •Might be difficult for some people to administer properly
    •Only used as add-on therapy to other asthma medications
    •Hasn't been studied during pregnancy or while breastfeeding
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Tezspire vs. Dupixent

    Common Side Effects for
    •Sore throat (4%)
    •Joint pain or stiffness (4%)
    •Back pain (4%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Tezspire vs. Dupixent

    Common Side Effects for
    •Severe allergic reaction
    •Unknown effect on your immune response to parasitic infections
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Tezspire vs. Dupixent

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    Learn more about Dupixent

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