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Compare Eucrisa vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Eucrisa (crisaborole) and Dupixent (dupilumab) are both used to treat eczema, but they have some key differences. Eucrisa is a topical ointment that you apply to your skin, while Dupixent is an injectable medication. Eucrisa works by blocking the phosphodiesterase 4 (PDE4) enzyme to reduce inflammation and itching, and it's safe for children as young as 3 months. On the other hand, Dupixent is a monoclonal antibody that targets specific proteins to calm the immune system and is approved for children as young as 6 months. Both Dupixent and Eucrisa are only available as brand medications, but Dupixent is an injection, making it potentially more expensive. Additionally, Dupixent treats a wider range of conditions, including asthma and sinus congestion with nasal polyps, and is administered every other week or monthly, compared to Eucrisa's twice-daily application. Common side effects of Eucrisa include application site pain, while Dupixent can cause injection site reactions and eye inflammation.

  • Eucrisa (crisaborole)
    Dupixent (dupilumab)
  • Eucrisa (crisaborole)
    Dupixent (dupilumab)

  • Summary of Eucrisa vs. Dupixent

    Summary for PDE4 inhibitor
    Prescription only

    Eucrisa (crisaborole) is an ointment that's used to treat eczema for people 3 months and older. The medication is a phosphodiesterase 4 (PDE4) inhibitor that works to help reduce skin inflammation and itching from eczema. The ointment is usually applied to the affected area(s) of skin twice a day. The most common side effect is burning or stinging on the skin where you apply the medication.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Eucrisa vs. Dupixent

    Indications for
    •Mild-to-moderate eczema
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Eucrisa vs. Dupixent

    Pros and Const for PDE4 inhibitor
    Pros
    •Easy-to-apply ointment
    •Safe to use on children as young as 3 months old
    •Can start to see improvement in your skin in about 1 week
    •An alternative to topical steroids to treat eczema
    Cons
    •Must use twice daily
    •Can cause pain, burning, or stinging on the skin
    •Not approved for severe eczema
    •No lower-cost generic available
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Eucrisa vs. Dupixent

    Common Side Effects for
    •Pain, burning, or stinging where the medication is applied (4%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Eucrisa vs. Dupixent

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Eucrisa vs. Dupixent

    Learn more about Eucrisa
    Learn more about Dupixent

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