Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Tremfya vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Dupixent (dupilumab) are both injectable medications used to treat different inflammatory conditions, but they have some key differences. Tremfya is specifically approved for moderate-to-severe plaque psoriasis and active psoriatic arthritis, while Dupixent is used for a wider range of conditions, including eczema, asthma, sinus congestion with nasal polyps, eosinophilic esophagitis, and prurigo nodularis. Tremfya works by blocking the IL-23 protein to reduce inflammation, whereas Dupixent blocks multiple proteins responsible for inflammation. Tremfya is typically injected every 8 weeks after the initial doses, while Dupixent's dosing varies from weekly to monthly depending on the condition being treated. Tremfya is only available as a brand-name medication, making it potentially more expensive, whereas Dupixent also lacks a generic form. Both medications can cause injection site reactions and increase the risk of infections, but Dupixent is more likely to cause eye inflammation and has a broader range of side effects.

  • Tremfya (guselkumab)
    Dupixent (dupilumab)
  • Tremfya (guselkumab)
    Dupixent (dupilumab)

  • Summary of Tremfya vs. Dupixent

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Tremfya vs. Dupixent

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Tremfya vs. Dupixent

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Tremfya vs. Dupixent

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Tremfya vs. Dupixent

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Tremfya vs. Dupixent

    Learn more about Tremfya
    Learn more about Dupixent

Compare other Plaque Psoriasis and Eczema drugs

Bimzelx vs TremfyaCosentyx vs TremfyaDuobrii vs TremfyaTremfya vs CosentyxTremfya vs DupixentTremfya vs EntyvioTremfya vs HumiraTremfya vs IlumyaTremfya vs OtezlaTremfya vs SkyriziTremfya vs StelaraTremfya vs TaltzBimzelx vs CosentyxCosentyx vs HumiraDuobrii vs BryhaliDuobrii vs CosentyxDuobrii vs EnstilarDuobrii vs ImpoyzDuobrii vs SkyriziEnbrel vs CosentyxEntyvio vs HumiraEntyvio vs OrtikosEntyvio vs RinvoqEntyvio vs SkyriziEntyvio vs StelaraInflectra vs EntyvioOtezla vs CosentyxRemicade vs EntyvioRinvoq vs CosentyxSkyrizi vs Cosentyx
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.