Key takeaways
Duobrii (halobetasol/tazarotene) and Taclonex (calcipotriene/betamethasone) are both topical treatments for plaque psoriasis, but they have some key differences. Duobrii combines a corticosteroid (halobetasol) and a retinoid (tazarotene), while Taclonex combines a corticosteroid (betamethasone) and a vitamin D analog (calcipotriene). Duobrii is only available as a brand-name lotion, which can be expensive, whereas Taclonex is available in multiple forms, including some lower-cost generics. Duobrii is not recommended for long-term use due to potential hormone changes and skin reactions, and it is not safe during pregnancy. Taclonex, on the other hand, can cause high calcium levels and adrenal gland problems, and its foam form is flammable. Both medications can make your skin more sensitive to sunlight, so you should use sunscreen and protective clothing when outside.
