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Compare Duobrii vs. Enstilar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Duobrii (halobetasol/tazarotene) and Taclonex (calcipotriene/betamethasone) are both topical treatments for plaque psoriasis, but they have some key differences. Duobrii combines a corticosteroid (halobetasol) and a retinoid (tazarotene), while Taclonex combines a corticosteroid (betamethasone) and a vitamin D analog (calcipotriene). Duobrii is only available as a brand-name lotion, which can be expensive, whereas Taclonex is available in multiple forms, including some lower-cost generics. Duobrii is not recommended for long-term use due to potential hormone changes and skin reactions, and it is not safe during pregnancy. Taclonex, on the other hand, can cause high calcium levels and adrenal gland problems, and its foam form is flammable. Both medications can make your skin more sensitive to sunlight, so you should use sunscreen and protective clothing when outside.

  • Duobrii (halobetasol / tazarotene)
    Enstilar (calcipotriene / betamethasone)
  • Duobrii (halobetasol / tazarotene)
    Enstilar (calcipotriene / betamethasone)

  • Summary of Duobrii vs. Enstilar

    Summary for Corticosteroid / Retinoid
    Prescription only

    Duobrii is a combination medication that contains halobetasol (a corticosteroid) and tazarotene (a retinoid). It's a prescription topical lotion that's FDA-approved to treat plaque psoriasis in adults. The directions for using the medication are to apply a thin amount over the affected area(s) of skin once per day. But avoid putting on the face, groin, and underarms. Side effects aren't common, but can include skin rash and pain at the site of application. Duobrii is brand name only and not available as a generic.

    Summary for Vitamin D analog / Corticosteroid
    Prescription only

    Enstilar (calcipotriene / betamethasone) is used to treat plaque psoriasis in people 12 years and older. It's a topical foam that contains two medications: calcipotriene (a form of vitamin D) and betamethasone (a corticosteroid). It's applied to the skin once a day, for up to 1 month. Side effects aren't common, but can include irritation and itching where you apply the medication. Enstilar (calcipotriene / betamethasone) is brand name only and not available as a generic.

  • Indications of Duobrii vs. Enstilar

    Indications for
    •Plaque psoriasis in adults
    Indications for
    •Plaque psoriasis

  • Pros and Cons of Duobrii vs. Enstilar

    Pros and Const for Corticosteroid / Retinoid
    Pros
    •Applied once daily
    •Combines two medications into one lotion
    •Might see some improvements in as early as 2 weeks
    Cons
    •For adults only; not studied in children
    •Not safe to use while pregnant or breastfeeding
    •Available as a brand-name product only
    Pros and Const for Vitamin D analog / Corticosteroid
    Pros
    •Only applied once a day
    •Foam, might be easier to apply than other formulations
    •Might see results in as early as 3 days
    Cons
    •No lower-cost generic available
    •Not approved for children under 12 years old
    •Not meant for long-term use

  • Common Side Effects of Duobrii vs. Enstilar

    Common Side Effects for
    •Skin rash (7%)
    •Pain where the medication was applied (3%)
    Common Side Effects for

  • Warnings of Duobrii vs. Enstilar

    Common Side Effects for
    •Harm to unborn babies
    •Altered stress hormone levels
    •Skin reactions and skin infections
    •Sun sensitivity and risk of sunburn
    •Cataracts and glaucoma
    Common Side Effects for
    •Flammable
    •High calcium levels
    •Changes in stress hormone levels
    •Allergic skin reaction
    •Cataracts and glaucoma

  • Prices with our coupons for Duobrii vs. Enstilar

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    Learn more about Enstilar

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