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Compare Humira vs. Hydroxychloroquine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Humira (adalimumab)
    Hydroxychloroquine (Plaquenil)
  • Humira (adalimumab)
    Hydroxychloroquine (Plaquenil)

  • Summary of Humira vs. Hydroxychloroquine

    Summary for TNF blocker
    Prescription only

    Humira (adalimumab) is an injection used to treat many different autoimmune conditions like rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. As a TNF blocker, the medication works by blocking a protein that causes inflammation in your body. It's given as a shot under the skin once every 1 to 2 weeks, depending on your condition. Humira (adalimumab) doesn't have a true generic, but there are several similar versions called biosimilars. Common side effects include infections, injection site reactions, and headache.

    Summary for Anti-malarial agent
    Prescription only

    Hydroxychloroquine (Plaquenil) is a non-biologic disease-modifying anti-rheumatic drug (DMARD) used to treat rheumatoid arthritis (RA) and lupus in adults. It's also an antimalarial medication used to prevent and treat malaria in adults and children. Hydroxychloroquine (Plaquenil) is taken by mouth, typically once or twice per day. Some of the more common side effects of this medication include nausea, vomiting, and diarrhea.

  • Indications of Humira vs. Hydroxychloroquine

    Indications for
    •Rheumatoid arthritis (RA) - adults only
    •Juvenile idiopathic arthritis (JIA) - people age 2 and older
    •Psoriatic arthritis (PsA) - adults only
    •Ankylosing spondylitis (AS) - adults only
    •Crohn's disease (CD) - people age 6 and older
    •Ulcerative colitis (UC) - people age 5 and older
    •Plaque psoriasis - adults only
    •Hidradenitis suppurativa (HS) - people age 12 and older
    •Uveitis - people age 2 and older
    Indications for
    •Uncomplicated malaria in adults and children
    •Rheumatoid arthritis (RA) in adults
    •Systemic lupus erythematosus (SLE) in adults
    •Discoid lupus erythematosus (DLE) in adults

  • Pros and Cons of Humira vs. Hydroxychloroquine

    Pros and Const for TNF blocker
    Pros
    •Can be used for many autoimmune conditions
    •Available as a ready-to-use pen that makes it easier to self-inject at home
    •Can be used in young children (as young as 2 years old for some conditions)
    •Only needs to be injected a couple times a month
    •Can be left at room temperature for up to 14 days if needed
    Cons
    •Raises the risk of serious infections
    •Can take a few weeks or longer to work
    •Might be difficult to inject for some people
    •Can't receive any live vaccines while taking the medication
    •Might contain rubber or latex, which can cause a reaction for those with an allergy
    Pros and Const for Anti-malarial agent
    Pros
    •Taken by mouth
    •Can be taken once per day
    •Possible option for RA during pregnancy
    Cons
    •Need to take with food or milk
    •Interacts with commonly prescribed medications, such as certain blood sugar medications or antibiotics
    •Can't be used in children for lupus

  • Common Side Effects of Humira vs. Hydroxychloroquine

    Common Side Effects for
    •Injection-site reaction (20%)
    •Upper respiratory tract infection (17%)
    •Headache (12%)
    •Rash (12%)
    •Sinus inflammation (11%)
    •Accidental injury (10%)
    •Nausea (9%)
    •Urinary tract infection (UTI) or bladder infection (8%)

    Note: The side effects listed above were reported by adults with rheumatoid arthritis and are similar to those seen in people using Humira (adalimumab) for other conditions.

    Common Side Effects for
    •Nausea and vomiting (up to 37%)
    •Diarrhea (up to 37%)
    •Bloating (up to 37%)

  • Warnings of Humira vs. Hydroxychloroquine

    Common Side Effects for
    •Serious infections
    •Cancers
    •Severe allergic reactions
    •Nervous system effects
    •Low blood cell counts
    •Heart failure
    •Lupus-like syndrome
    •Live vaccines
    Common Side Effects for
    •Serious heart rhythm problems
    •Build-up of phospholipids (a type of fat)
    •Eye damage
    •Severe skin and allergic reactions
    •Lower blood cell counts
    •Hemolytic anemia (low red blood cells)
    •Suicidal thoughts
    •Lower blood sugar levels
    •Worsening of certain medical conditions

  • Prices with our coupons for Humira vs. Hydroxychloroquine

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    Learn more about Hydroxychloroquine

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