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Compare Sotyktu vs. Otezla

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sotyktu (deucravacitinib)
    Otezla (apremilast)
  • Sotyktu (deucravacitinib)
    Otezla (apremilast)

  • Summary of Sotyktu vs. Otezla

    Summary for Tyrosine kinase 2 inhibitor
    Prescription only

    Sotyktu (deucravacitinib) is a tyrosine kinase 2 (TYK2) inhibitor that's used to treat moderate-to-severe plaque psoriasis in adults. It's a tablet that's taken by mouth once per day. Side effects include a higher risk of infections, such as upper respiratory infections and herpes simplex infections. Sotyktu (deucravacitinib) is a brand-name medication and available by prescription only.

    Summary for PDE-4 inhibitor
    Prescription only

    Otezla (apremilast) is a tablet that's taken by mouth. It's used to treat plaque psoriasis, psoriatic arthritis, and mouth sores from Behçet’s disease. This medication belongs to the drug class called phosphodiesterase-4 (PDE-4) inhibitors. You usually start Otezla (apremilast) at a low dose. Then, the dose is slowly raised over 5 days to lower the risk of side effects like nausea and diarrhea. This medication is available as a brand-name medication. Generic versions of apremilast likely won't be available until at least 2028.

  • Indications of Sotyktu vs. Otezla

    Indications for
    •Moderate-to-severe plaque psoriasis
    Indications for
    •Active psoriatic arthritis in adults
    •Moderate-to-severe plaque psoriasis in people age 6 years and older weighing at least 44 lbs
    •Mouth sores from Behçet’s disease in adults

  • Pros and Cons of Sotyktu vs. Otezla

    Pros and Const for Tyrosine kinase 2 inhibitor
    Pros
    •Taken by mouth once a day
    •Can take with or without food
    •Safe to take if you have kidney problems or mild-to-moderate liver problems
    Cons
    •Can raise the risk for new or worsening infections
    •Have to get blood work periodically done during treatment to check for side effects
    •Hasn't been studied in children
    Pros and Const for PDE-4 inhibitor
    Pros
    •Taken by mouth
    •Can take with or without food
    •Dose adjustment available for people with severe kidney problems
    Cons
    •Dosing schedule can be confusing in the beginning
    •Common to have nausea or diarrhea in the beginning
    •Might not be a good option for people who've had depression or suicidal behavior

  • Common Side Effects of Sotyktu vs. Otezla

    Common Side Effects for
    •Upper respiratory infections (19%)
    Common Side Effects for
    •Diarrhea (17%)
    •Nausea (17%)
    •Upper respiratory tract infection (e.g., common cold; 9%)
    •Headache (6%)

  • Warnings of Sotyktu vs. Otezla

    Common Side Effects for
    •Severe allergic reactions
    •Serious infections
    •Muscle damage
    •Liver damage
    •Possible risk of cancer
    Common Side Effects for
    •Allergic reaction
    •Diarrhea, nausea, and vomiting
    •Depression
    •Possible weight loss
    •Drug interactions

  • Prices with our coupons for Sotyktu vs. Otezla

    Learn more about Sotyktu
    Learn more about Otezla

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