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Compare Zeposia vs. Ocrevus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zeposia (ozanimod) and Ocrevus (ocrelizumab) are both medications used to treat multiple sclerosis (MS). However, they belong to different medication classes and have distinct uses and administration methods. Zeposia is a sphingosine 1-phosphate receptor modulator taken orally, while Ocrevus is a monoclonal antibody given as an infusion. Zeposia is also approved for treating moderate-to-severe ulcerative colitis (UC), whereas Ocrevus is the only FDA-approved medication for primary progressive MS. Zeposia is taken daily, with a starter pack to gradually increase the dose, while Ocrevus is administered every six months after initial doses. Common side effects of Zeposia include upper respiratory infections and liver enzyme changes, while Ocrevus can cause infusion reactions and upper respiratory tract infections. Both medications can increase the risk of infections. Rarely, Ocrevus may increase your risk of some types of cancers.

  • Zeposia (ozanimod)
    Ocrevus (ocrelizumab)
  • Zeposia (ozanimod)
    Ocrevus (ocrelizumab)

  • Summary of Zeposia vs. Ocrevus

    Summary for S1P receptor modulator
    Prescription only

    Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.

    Summary for Monoclonal antibody
    Prescription only

    Ocrevus (ocrelizumab) is used to treat multiple sclerosis (MS) in adults. It's a type of medication called a monoclonal antibody. It's given as an infusion through the vein every 6 months at a medical center or clinic. A trained healthcare professional will help give Ocrevus (ocrelizumab) to you. Side effects can include a higher risk of infections and infusion reactions.

  • Indications of Zeposia vs. Ocrevus

    Indications for
    •Relapsing forms of multiple sclerosis (MS) in adults
    •Moderate-to-severe ulcerative colitis (UC) in adults
    Indications for
    •All types of multiple sclerosis (MS)

  • Pros and Cons of Zeposia vs. Ocrevus

    Pros and Const for S1P receptor modulator
    Pros
    •Taken by mouth, with or without food
    •Taken once a day
    •Starter pack available to help guide dosing at the beginning of treatment
    Cons
    •Might raise your risk of infections
    •Not safe for people with certain heart problems or severe liver problems
    •Not approved for children
    Pros and Const for Monoclonal antibody
    Pros
    •Given twice a year (after a couple starter doses)
    •Can help lessen the number of relapses for all types of MS
    •Might be better tolerated than some other injectable MS medications
    Cons
    •Must be given as an infusion through the vein over a few hours at a medical office
    •Can raise your risk of infections
    •Doesn't cure MS

  • Common Side Effects of Zeposia vs. Ocrevus

    Common Side Effects for
    •Upper respiratory infection (26%)
    •High liver enzyme levels (10%)
    Common Side Effects for
    •Upper respiratory tract infections (40%)
    •Infusion reactions (34%)

  • Warnings of Zeposia vs. Ocrevus

    Common Side Effects for
    •Risk of infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Slow heart rate and heart rhythm
    •Higher blood pressure
    •Liver damage
    •Breathing problems
    •Eye problem called macular edema
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    •Possible risk of skin cancer
    •Harm to an unborn baby
    Common Side Effects for
    •Infusion reactions
    •Risk of serious infections
    •Lower antibody levels
    •Serious inflammation of the colon
    •Possible higher risk of cancer

  • Prices with our coupons for Zeposia vs. Ocrevus

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    Learn more about Ocrevus

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