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Compare Zeposia vs. Ocrevus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • zeposia (ozanimod)
    Ocrevus (ocrelizumab)
  • zeposia (ozanimod)
    Ocrevus (ocrelizumab)

  • Summary of Zeposia vs. Ocrevus

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Zeposia (ozanimod) is a sphingosine 1-phosphate (S1P) receptor modulator that's used to treat adults with ulcerative colitis (UC) or relapsing forms of multiple sclerosis (MS). It's a capsule that's taken by mouth, usually once per day (or as directed by your provider if you have certain liver problems). There are starter packs of the medication that help you slowly raise the dosage to a maintenance dosage over a week. Side effects typically depend on your medical condition, but generally include infections and changes in liver tests.

    Summary for Monoclonal antibody
    Prescription only

    Ocrevus (ocrelizumab) is a medication used to treat multiple sclerosis (MS). It's an infusion through the veins that's given by a healthcare provider at their office, at an infusion center, or at home (if your provider allows). You don't have to take Ocrevus (ocrelizumab) as often as some other MS medications.

  • Indications of Zeposia vs. Ocrevus

    Indications for
    •Relapsing forms of multiple sclerosis (MS) in adults
    •Moderate-to-severe ulcerative colitis (UC) in adults
    Indications for
    •All types of multiple sclerosis (MS)

  • Pros and Cons of Zeposia vs. Ocrevus

    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Only need to take up to once daily
    •7-capsule starter pack available to help make it easier to know what dose to take at the beginning of treatment
    •Can start to work within a couple weeks to improve UC symptoms
    •Many people with MS are relapse-free after taking this medication for 1 year
    Cons
    •Must raise your dose slowly over the first week of treatment, which can be confusing
    •Might raise your risk of infections
    •Unknown if it works well or is safe to use for children under 18 years of age
    •Not recommended for use in people with severe liver problems
    Pros and Const for Monoclonal antibody
    Pros
    •Given twice per year (after a couple starter doses)
    •The only FDA-approved medication for primary progressive MS
    •Might be better tolerated than some other injectable MS medications
    •Manufacturer co-pay program available to help lower costs for eligible people
    Cons
    •Needs to be given as an infusion injected through the vein
    •Cannot be used in children or adults older than 64 years old
    •Brand name only, which can be expensive
    •Raises your risk for infections

  • Common Side Effects of Zeposia vs. Ocrevus

    Common Side Effects for
    •Upper respiratory infection (26%)
    •High liver enzyme tests (10%)
    Common Side Effects for
    •Upper respiratory tract infections (40-49%)
    •Infusion reactions (34-40%)
    •Skin infections (up to 14%)
    •Lower respiratory tract infections (8-10%)

  • Warnings of Zeposia vs. Ocrevus

    Common Side Effects for
    •Serious infections
    •Progressive multifocal leukoencephalopathy (PML)
    •Dangerously slow heart rate
    •High blood pressure
    •Liver damage
    •Harm to unborn babies
    •Breathing problems
    •Eye problems
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    Common Side Effects for
    •Reactions after injection
    •Risk of infections
    •Low antibodies
    •Cancer

  • Prices with our coupons for Zeposia vs. Ocrevus

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    Learn more about Ocrevus

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