provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Orencia Coupon - Orencia 4 clickject autoinjectors of 125mg/ml carton

Orencia

abatacept
Used for Rheumatoid Arthritis, Psoriatic Arthritis
Used for Rheumatoid Arthritis, Psoriatic Arthritis

Orencia (abatacept) is an injectable biologic medication used for different types of autoimmune arthritis (joint inflammation), including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). It's given as an injection under the skin once a week or as an infusion through the veins (IV) in the clinic once a month. Common side effects include infection, headache, and dizziness.

Last reviewed on June 7, 2023
basics-icon

What is Orencia (abatacept)?

What is Orencia (abatacept) used for?

How Orencia (abatacept) works

Orencia (abatacept) is a biologic disease-modifying anti-rheumatic drug (DMARD). It blocks certain proteins and processes in cells, which lowers inflammation. This prevents specific types of arthritis from getting worse.

Drug Facts

Common BrandsOrencia
Drug ClassBiologic DMARD
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Orencia (abatacept) essentials

coupon-save-icon

Get your GoodRx coupon

Avg retail price
$8259.33(save 32.89%)
GoodRx discount
$5542.67
See prices
basics-icon

What are the side effects of Orencia (abatacept)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (18%)
  • Sore throat, runny nose, or other cold-like symptoms (12%)
  • Dizziness (9%)
  • Cough (8%)
  • Back pain (7%)
  • High blood pressure (7%)
  • Upset stomach (6%)
  • Pain while urinating and other symptoms of an urinary tract infection (6%)
Please note: The side effects above were reported by adults who received Orencia (abatacept) for rheumatoid arthritis. The side effects you experience might be different if you're taking Orencia (abatacept) for a different condition or if you're injecting it under the skin.

Other Side Effects

  • Rash
  • Pain in the hands and feet

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infections: fever, tiredness, chills, cough, trouble breathing
  • Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Back pain

bladder pain

bloody or cloudy urine

body aches or pain

chills

cough

cough producing mucus

difficult, burning, or painful urination

difficult or labored breathing

dizziness

ear congestion

fever

frequent urge to urinate

headache

loss of voice

lower back or side pain

nausea or vomiting

noisy breathing

pain or tenderness around the eyes and cheekbones

sneezing

sore throat

stuffy or runny nose

tightness of the chest

trouble breathing

unusual tiredness or weakness

Less common

Blurred vision

burning or stinging of the skin

chest pain

nervousness

painful cold sores or blisters on the lips, nose, eyes, or genitals

pounding in the ears

skin rash

slow or fast heartbeat

Rare

Confusion

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

flushing

hives or welts

itching, pain, redness, swelling, tenderness, or warmth on the skin

stomach pain or tenderness

sweating

swelling of the face, throat, or tongue

Incidence not known

Redness, soreness, or itching of the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

sores, welts, blisters

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Belching

bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

heartburn

indigestion

stomach discomfort or upset

Less common

Diarrhea

pain in the arms or legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Orencia (abatacept)

thumbs-up

Pros

Can be used in children age 2 years and older (for certain conditions)

Comes as a prefilled syringe or autoinjector for easy at-home injections

Clinic infusions are available for people who don't like to give themselves injections and are generally given only once a month

SQ injections are given once weekly and IV infusions are given once monthly

thumbs-down

Cons

Raises your risk for infections because it weakens your immune system

Can't be used with other biologic medications because higher risk of infection

Can take 3 to 6 months to notice an improvement in your symptoms (for arthritis)

Only treats the symptoms and isn't a cure for inflammatory problems

pharmacist-tips

Pharmacist tips for Orencia (abatacept)

pharmacist
  • Make sure to mark your appointments on your calendar to see your provider and receive your Orencia (abatacept) dose if you're receiving it as an IV infusion. This will help make sure you're properly being monitored and won't miss any doses.

    • If you're receiving the Orencia (abatacept) IV infusion, let your provider know if you have diabetes and check your blood sugar at home. This is because Orencia (abatacept) can interfere with certain blood sugar test strips, which can cause falsely high blood sugar readings.

      Tips for using the Orencia (abatacept) prefilled syringes or autoinjectors at home:

      • Your provider will likely have you give yourself your first dose of Orencia (abatacept) in their office or clinic to make sure you know how to give yourself the medication correctly. Refer to the instructions for use for the prefilled syringe or the ClickJect Autoinjector and contact your provider or pharmacist if you have any questions.

        • Store Orencia (abatacept) prefilled syringes or autoinjectors in the refrigerator and in its original packaging to protect it from light. When it's time for your dose, take a dose out of the refrigerator and lay it on a flat surface to warm up to room temperature. This will take about 30 minutes. Don't try to warm up the medication any other way (e.g., microwave, under hot water) because you might damage it.

          • Before you inject Orencia (abatacept), always check to make sure the liquid is clear and colorless to a pale yellow. If your medication is cloudy, discolored, or has specks floating in it, don't use it. Contact your provider or pharmacist to get a replacement.

            • Inject Orencia (abatacept) under the skin in the front of your middle thighs, lower part of your stomach, or your outer upper arms if someone else is giving you the injection. If you choose to inject into the stomach, inject 2 inches away from your belly button. Never inject into a muscle or vein.

              • To lower the risk of bruising and irritation, rotate between different injection sites each time so that the same area isn't used repeatedly. Don't inject Orencia (abatacept) into skin that's tender, red, bruised, scaly, hard, or has scars or stretch marks.

                • Throw away used syringes and needles in a sharps container or something made of heavy-duty plastic (e.g., empty milk carton, laundry detergent bottle) to lower the risk of needlestick injuries. Don't throw them away in your trash can.

                  • Each Orencia (abatacept) prefilled syringe and autoinjector provides a single dose of medication. You must throw away any leftover medication after each use, even if there's still some remaining in the syringe.

                    faqs

                    Frequently asked questions about Orencia (abatacept)

                    How long does it take for Orencia (abatacept) to work?
                    In clinical studies of people with RA, those who received IV Orencia (abatacept), sometimes along with other RA medications, typically started to feel better in about 3 to 6 months. But everyone responds differently to medications, so it's possible Orencia (abatacept) might work slower or faster for you. Contact your provider if you're not sure if Orencia (abatacept) is helping your symptoms.
                    How long does Orencia (abatacept) stay in your body?
                    If you've been taking Orencia (abatacept) for RA, it might take anywhere between over a month to close to 5 months for most of this medication to leave your body after you stop treatment. Keep in mind that this time frame is estimated based on the half-life of Orencia (abatacept). It can also be affected by your health conditions, so it can be different for each individual person. Discuss with your healthcare provider if you have questions about how long the medication stays in your body.
                    Is Orencia (abatacept) the same as methotrexate?
                    No, Orencia (abatacept) isn't the same as methotrexate. Methotrexate is another medication that can prevent RA from worsening, but it works differently than Orencia (abatacept). If you have RA, your provider might prescribe both medications to treat your symptoms. In fact, research shows that for people who still have RA symptoms with methotrexate, adding Orencia (abatacept) to the treatment might improve their symptoms. Talk with your provider if you've more questions about Orencia (abatacept) or methotrexate.
                    Does Orencia (abatacept) cause weight gain?
                    No, weight gain wasn't a reported side effect of Orencia (abatacept) during clinical trials.
                    Does Orencia (abatacept) cause hair loss?
                    No. While some people experience hair loss with some other arthritis medications, such as methotrexate or adalimumab (Humira), hair loss isn't a side effect reported by people who took Orencia (abatacept) in clinical trials.
                    Can I use Orencia (abatacept) if I'm pregnant?
                    There's limited research regarding whether Orencia (abatacept) is safe to take during pregnancy. Available data from animal studies show that Orencia (abatacept) didn't cause birth defects. But results in animal studies might not always apply to people. If you're pregnant or thinking of getting pregnant, talk to your provider about the risks and benefits of using Orencia (abatacept).
                    Can I use Orencia (abatacept) if I'm breastfeeding?
                    There isn't much information about how Orencia (abatacept) might affect breastfeeding. A single report showed that very little of this medication gets into breast milk and doesn't cause side effects for the breastfed baby. But to be safe, don't breastfeed your baby while taking Orencia (abatacept) without talking to your provider first.
                    GoodRxEducationalIcon

                    How to save using GoodRx

                    Compare Prices
                    1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                    Select your free coupon
                    2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                    Show coupon to your pharmacist
                    3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                    Get free couponLearn more
                    warings-icon

                    What are the risks and warnings for Orencia (abatacept)?

                    Orencia (abatacept) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Risk of serious infections

                    • Risk factors: Active, chronic (long-term), or recurrent infection | Other conditions that raise your risk of infection | Taking medications that weaken your immune system

                      Orencia (abatacept) can make it more difficult for your body to fight off infections. This raises your risk of bacterial, viral, or fungal infections. The risk is higher for people who are taking or have recently taken other medications that weaken the immune system. Additionally, Orencia (abatacept) might reactivate (wake up) certain viruses that are already in your body, such as tuberculosis (TB) or hepatitis B. If you develop an infection, your provider will likely ask you to stop taking Orencia (abatacept) until your body fights off the infection. Let your provider know if you experience symptoms of these infections, such as fever, cough, difficulty breathing, or weakness.

                      risk-warning

                      Severe allergic reactions

                      Severe allergic reactions to Orencia (abatacept) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). If you notice dizziness, a choking sensation, nausea, swelling around your eyes, swelling of the lips or tongue, or difficulty breathing after using Orencia (abatacept), get medical attention right away.

                      risk-warning

                      Vaccines

                      There's limited information available on the effects of Orencia (abatacept) on your body's response to vaccines, including live vaccines. Make sure your shots are up-to-date before starting Orencia (abatacept). Talk with your prescriber before you receive any vaccines while receiving Orencia (abatacept) treatment. Avoid getting live vaccines while you're taking Orencia (abatacept), and for at least 3 months after the last dose, because there's a risk that you can get sick from them.

                      risk-warning

                      Worsening breathing problems

                      In clinical trials, adults with chronic obstructive pulmonary disease (COPD) who were treated with Orencia (abatacept) had more COPD-related side effects. If you have COPD, make sure you monitor your symptoms, such as shortness of breath and cough. Let your provider know if they get worse while taking Orencia (abatacept).

                      risk-warning

                      Falsely high blood sugars

                      • Risk factors: Using Orencia (abatacept) IV infusion | Type 1 or type 2 diabetes | Using insulin | Using glucose meters that use GDH-PQQ

                        The Orencia (abatacept) IV infusion contains maltose, which is a type of sugar that can cause your blood sugar readings to be falsely high if you use certain blood sugar monitors that use a substance called GDH-PQQ to detect blood sugar. This raises your risk for low blood sugar (hypoglycemia) if you give yourself insulin to correct this falsely high blood sugar. Contact your local pharmacist or the manufacturer of the glucose monitor test you use if you're not sure if it can be used with products that have maltose in them.

                        dosage

                        Orencia (abatacept) dosage forms

                        Typical dosing for Orencia (abatacept)

                        Rheumatoid arthritis and psoriatic arthritis in adults

                        • Intravenous (IV): Your provider will calculate the dose based on your body weight. The typical dose ranges from 500 mg to 1,000 mg infused IV every 2 weeks for 3 doses, then every month after that.

                        • Under the skin injection: The typical dose is 125 mg injected under the skin once weekly.

                        Juvenile idiopathic arthritis

                        • Intravenous (IV): Your child's provider will calculate the dose based on their body weight. The typical dose is 10 mg/kg infused IV every 2 weeks for 2 doses, then every month after that. Children weighing 75 kg or more will be given the adult dose for arthritis.

                        • Under the skin injection: Your child's provider will calculate the dose based on your child's body weight. The typical dose is injected under the skin once weekly.

                          • Children weighing 10 kg to less than 25 kg: 50 mg

                          • Children weighing 25 kg to less than 50 kg: 87.5 mg

                          • Children weighing 50 kg or more: 125 mg

                        Prevention graft-versus-host disease

                        • Your provider will calculate the dose based on your body weight and age. The typical dose ranges from 10 mg/kg to 15 mg/kg infused through the veins the day before transplant, then on Day 5, 14, and 28 after transplant.

                        More on Orencia (abatacept) dosage forms

                        interactions

                        Interactions between Orencia (abatacept) and other drugs

                        Orencia (abatacept) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Orencia (abatacept). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        • Adalimumab
                        • Anakinra
                        • Baricitinib
                        • Certolizumab Pegol
                        • Etanercept
                        • Fedratinib
                        • Golimumab
                        • Guselkumab
                        • Infliximab
                        • Ixekizumab
                        • Rituximab
                        • Ruxolitinib
                        • Sarilumab
                        • Secukinumab
                        • Tocilizumab
                        • Tofacitinib
                        • Upadacitinib
                        • Ustekinumab

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        drug-cost

                        How much does Orencia (abatacept) cost?

                        To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                        alternatives

                        What are alternatives to Orencia (abatacept)?

                        There are a number of medications that your doctor can prescribe in place of Orencia (abatacept). Compare a few possible alternatives below.
                        Orencia (abatacept)
                        Used for:
                        $5542.67 Lowest GoodRx priceView Prices
                        Used for:
                        • Rheumatoid arthritis (RA)

                        • Plaque psoriasis (PsO) and psoriatic arthritis (PsA)

                        • Ankylosing spondylitis (AS)

                        • Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

                        $7418.24 Lowest GoodRx priceView Prices
                        Used for:
                        • Rheumatoid arthritis (RA) - adults only

                        • Juvenile idiopathic arthritis (JIA) - people age 2 and older

                        • Psoriatic arthritis (PsA) - adults only

                        • Ankylosing spondylitis (AS) - adults only

                        • Crohn's disease (CD) - people age 6 and older

                        • Ulcerative colitis (UC) - people age 5 and older

                        • Plaque psoriasis - adults only

                        • Hidradenitis suppurativa (HS) - people age 12 and older

                        • Uveitis - people age 2 and older

                        $1115.35 Lowest GoodRx priceView Prices
                        latest news

                        What is the latest news about Orencia (abatacept)?

                        images

                        Orencia (abatacept) images

                        yellow - ORENCIA ClickJect 125mg / mL Auto Injector Solution for Injection
                        This medicine is Yellow Carton.yellow - ORENCIA ClickJect 125mg / mL Auto Injector Solution for Injection

                        Get savings updates for Orencia (abatacept)

                        Receive price alerts, news, and other messages from GoodRx about Orencia (abatacept) and other healthcare topics and relevant savings offers.

                        By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                        References

                        Best studies we found

                        Bristol-Myers Squibb Company. (2020). How to take Orencia: Instructions for injecting the Orencia prefilled syringe with BD UltraSafe Passive™ Needle Guard.

                        Bristol-Myers Squibb Company. (2023). How to take Orencia: Instructions for injecting the Orencia ClickJect™ Autoinjector.

                        Drugs and Lactation Database (LactMed). (2023). Abatacept. National Institute of Child Health and Human Development.

                        View All References (4)

                        E.R. Squibb & Sons, L.L.C. (2023). Orencia- abatacept injection, powder, lyophilized, for solution; abatacept injection, solution [package insert]. DailyMed.

                        Justiz Vaillant, A., et al. (2024). Graft-Versus-Host Disease. StatPearls.

                        National Institute of Arthritis and Musculoskeletal and Skin Diseases. (2021). Juvenile idiopathic arthritis (JIA).

                        Wagner, E. (2023). Do psoriatic arthritis biologics cause weight gain? My Psoriasis Team.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                        Was this page helpful?

                        Browse medications

                        View All

                        Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.