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Compare Zinbryta vs. Tecfidera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Daclizumab (Zinbryta) and dimethyl fumarate (Tecfidera) are both medications used to treat relapsing forms of multiple sclerosis (MS) in adults. However, they belong to different medication classes and have distinct characteristics. Daclizumab is a monoclonal antibody that was available as an injection but has been discontinued due to safety concerns, including liver injury and immune-related problems. In contrast, dimethyl fumarate is a fumaric acid derivative available as an oral capsule, which you take twice a day. Dimethyl fumarate comes has both a brand and a generic version. Common side effects of dimethyl fumarate include stomach upset and flushing. Dimethyl fumarate can also weaken your immune system, increasing the risk of infections, and requires regular blood tests to monitor liver health and white blood cell counts.

  • Zinbryta (daclizumab)
    Dimethyl fumarate (Tecfidera)
  • Zinbryta (daclizumab)
    Dimethyl fumarate (Tecfidera)

  • Summary of Zinbryta vs. Tecfidera

    Summary for Monoclonal antibody

    Zinbryta (daclizumab) is a medication used to treat relapsing forms of multiple sclerosis (MS) in adults. It's no longer available in the United States, because it was discontinued.

    Summary for Fumaric acid derivative
    Prescription only

    Dimethyl fumarate (Tecfidera) is used to treat adults with certain types of multiple sclerosis (MS), a condition that affects your nervous system. This medication is a disease-modifying therapy (DMT) that belongs to the drug class called fumaric acid derivatives. Dimethyl fumarate (Tecfidera) is available as a brand-name medication and a lower-cost generic. The capsules are taken by mouth twice per day. The most common side effects are stomach upset and flushing (e.g., facial warmth, redness, burning sensation).

  • Indications of Zinbryta vs. Tecfidera

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)

  • Pros and Cons of Zinbryta vs. Tecfidera

    Pros and Const for Monoclonal antibody
    Pros
    Cons
    Pros and Const for Fumaric acid derivative
    Pros
    •Works well to lessen MS relapses
    •Can take with or without food
    •Available as a lower-cost generic medication
    •No known interactions with other medications or supplements
    Cons
    •Need to take twice a day
    •Might need MRI scans to see whether the medication is working for you
    •Might need to have regular blood work done to make sure the medication isn't causing any liver problems
    •Can cause more bothersome stomach-related side effects than Vumerity (diroximel fumarate)

  • Common Side Effects of Zinbryta vs. Tecfidera

    Common Side Effects for
    Common Side Effects for
    •Flushing (40%)
    •Stomach pain (18%)
    •Diarrhea (14%)
    •Nausea (12%)
    •Vomiting (9%)
    •Itchiness (8%)
    •Rash (8%)

  • Warnings of Zinbryta vs. Tecfidera

    Common Side Effects for
    Common Side Effects for
    •Severe allergic reactions
    •Serious infections
    •Low white blood cell counts (lymphopenia)
    •Liver damage
    •Flushing
    •Serious stomach and intestine problems

  • Prices with our coupons for Zinbryta vs. Tecfidera

    Learn more about Zinbryta
    Learn more about Dimethyl fumarate

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