Pyzchiva vs. Stelara for Plaque Psoriasis and Ulcerative Colitis: Important Differences and Potential Risks.

Pyzchiva

(ustekinumab)

Stelara

(ustekinumab)

Summary for Pyzchiva

Prescription only

Pyzchiva (ustekinumab or ustekinumab-ttwe) is a biosimilar to Stelara (ustekinumab) and is FDA-approved to treat the same autoimmune conditions, including psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It works by blocking certain proteins called interleukins that cause inflammation in the body. The medication is usually given as an injection under the skin. After a few starting doses, you'll take a dose every 8 or 12 weeks depending on your condition. Common side effects include headache, feeling tired, and having common cold symptoms.

Indications for Pyzchiva

Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
Psoriatic arthritis (PsA) - adults and children 6 years and older
Moderate-to-severe Crohn's disease (CD) - adults only
Moderate-to-severe ulcerative colitis (UC) - adults only

Pros and Cons for Pyzchiva

Pros

Biosimilar that's interchangeable with Stelara (ustekinumab)
Syringes can be stored at room temperature for up to 35 days
Approved for children as young as 6 years old for certain conditions
Stopper isn't made of natural rubber latex

Cons

Can weaken your immune system and raise your risk of infection
Potential to cause serious allergic reactions
For CD and UC, the first dose must be given as an IV infusion
Can't receive live vaccines while taking this medication

Common Side Effects for Pyzchiva

Plaque psoriasis:

Common cold symptoms (7-8%)
Upper respiratory tract infection (4-5%)
Headache (5%)

Psoriatic arthritis:

Joint pain (3%)
Nausea (3%)

Crohn's disease:

Common cold symptoms (11%)
Redness at the injection site (5%)
Yeast infection (5%)
Bronchitis (5%)

Ulcerative colitis:

Common cold symptoms (24%)
Headache (10%)
Stomach pain (7%)
Flu infection (6%)
Fever (5%)

Warnings for Pyzchiva

Infections
Cancers
Severe allergic reaction
Brain condition
Vaccines
Lung problems

Summary for Stelara

Prescription only

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

Indications for Stelara

Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
Psoriatic arthritis (PsA) - adults and children 6 years and older
Moderate-to-severe Crohn's disease (CD) - adults only
Moderate-to-severe ulcerative colitis (UC) - adults only

Pros and Cons for Stelara

Pros

After the first few doses, only need a shot every 8 to 12 weeks
Available as a prefilled syringe or vial
Syringes can be stored at room temperature for up to 30 days
Approved for children as young as 6 years old

Cons

Can weaken your immune system and raise your risk of infection
Potential to cause serious allergic reactions
For CD and UC, the first dose must be given as an IV infusion
Can't receive live vaccines while taking this medication

Common Side Effects for Stelara

Plaque psoriasis

Common cold symptoms (7-8%)
Upper respiratory tract infection (4-5%)
Headache (5%)

Psoriatic arthritis

Joint pain (3%)
Nausea (3%)

Crohn's disease

Common cold symptoms (11%)
Redness at the injection site (5%)
Yeast infection (5%)
Bronchitis (5%)

Ulcerative colitis:

Common cold symptoms (24%)
Headache (10%)
Stomach pain (7%)
Flu infection (6%)
Fever (5%)

Warnings for Stelara

Infections
Cancers
Severe allergic reaction
Brain condition
Vaccines
Lung problems

Prices with our coupons for Pyzchiva vs. Stelara

Pyzchiva1 syringe / 1ml of 90mg/ml

$4,015.63$4,839.10

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Ustekinumab1 syringe / 1ml of 90mg/ml

$7,002.73$9,607.09

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Pyzchiva vs. Stelara

Pyzchiva

Stelara

Summary for Pyzchiva

Indications for Pyzchiva

Pros and Cons for Pyzchiva

Pros

Cons

Common Side Effects for Pyzchiva

Warnings for Pyzchiva

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara

Prices with our coupons for Pyzchiva vs. Stelara

Browse medications by letter

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Pyzchiva

Stelara

Summary for Pyzchiva

Indications for Pyzchiva

Pros and Cons for Pyzchiva

Pros

Cons

Common Side Effects for Pyzchiva

Warnings for Pyzchiva

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara