Key takeaways:
Skyrizi (risankizumab-rzaa) is a prescription-only specialty medication that treats Crohn’s disease, plaque psoriasis, psoriatic arthritis, and ulcerative colitis. Depending on your diagnosis, this medication will be dispensed as an injection that’s self-administered or as an IV infusion.
Skyrizi is a brand-name medication and can be costly, with a list price of more than $22,000 per dose. Without insurance, a 150 mg/mL subcutaneous (under the skin) Skyrizi pen costs an average of $33083.60.
You may be able to reduce the cost of Skyrizi with a manufacturer copay savings card (if you have commercial insurance) or through a patient assistance program. You may also be able to save by using a GoodRx coupon.
Save on related medications
Skyrizi (risankizumab-rzaa) is a brand-name, prescription-only medication that treats several autoimmune conditions. These include plaque psoriasis, psoriatic arthritis, and inflammatory bowel disease.
This specialty medication is available as a subcutaneous (under the skin) injection that’s typically self-administered using a prefilled injection pen, a prefilled syringe, or an on-body injector device. Depending on your condition, Skyrizi may be delivered as an IV infusion in a healthcare setting.
Because Skyrizi is effective for several conditions, it is widely prescribed. Here’s how much you can expect to pay and how you may be able to save on this medication.
How much does Skyrizi cost?
The list price for Skyrizi was $22,383.49 per dose as of January 6, 2025, according to its manufacturer. But this is probably not the price you’ll pay.
Skyrizi, a specialty medication, is typically administered every 8 to 12 weeks following the starter doses. The starter doses are typically three IV infusions or two supervised under-the-skin injections in a medical setting. The cost of an IV dose may differ from the cost of an injection.
It’s important to note that Skyrizi is a biologic medication, meaning that it’s made using living systems. Biologics don’t have generics. Instead, they have biosimilars, which closely resemble the brand-name, or reference, product — but often cost less. There is not a biosimilar for Skyrizi currently available in the U.S.
Here are some average retail prices for Skyrizi.
Skyrizi Costs
Brand-name form and dose | Average retail price |
|---|---|
Prefilled injection pen, 150 mg/mL | |
Prefilled syringe, 150 mg/mL | |
On-body injector kit (prefilled cartridge), 180 mg/1.2 mL (150 mg/mL) | |
On-body injector kit (prefilled cartridge), 360 mg/2.4 mL (150 mg/mL) |
What factors affect the cost of Skyrizi?
Without insurance, what you pay for Skyrizi depends on several factors, including your:
Pharmacy: Since pharmacies set their own prices, and you can only get this medication at a specialty pharmacy, the price may vary based on where your prescription is filled.
Method of administration: Depending on what condition you’re treating, you may inject Skyrizi at home or receive an IV infusion in a healthcare setting — which may come with an additional charge. So the way you receive the medication can affect what you pay.
Location: Medication costs vary by geographic location. You may pay more in certain areas of the country.
Dosage: Because you may start taking this medication with a different dose or more frequent injections, you may pay a different price than another person prescribed the medication.
Fill quantity: Medications can be more affordable when you buy in bulk. For medications given periodically, like Skyrizi, you may be able to save just by buying more than one dose at a time.
Does insurance cover Skyrizi?
Nearly every health insurance plan in the U.S. covers Skyrizi. If you have insurance, review your plan’s summary of benefits and coverage and formulary (list of covered medications) to determine whether Skyrizi is covered. If not, contact your plan and ask about your coverage options. You can also discuss alternatives with your prescriber or pharmacist.
To get coverage for Skyrizi, most health insurance plans require prior authorization, which means your prescriber will have to provide documentation that the medication is medically necessary. Step therapy (when you need to try other medications first) is also required by many plans.
How different insurance plans cover Skyrizi
The following charts show the likelihood of having coverage for different self-administration methods of Skyrizi with various types of insurance plans. They also show the likelihood of needing to obtain prior authorization or complete step therapy.
What does Skyrizi (risankizumab-rzaa) treat? Read more about how this injectable, biologic medication works and what you can expect during treatment.
Skyrizi side effects: Depending on your condition, muscle and joint pain, skin rashes, and liver damage are some potential downsides of using this medication.
Here’s what taking Skyrizi is like. Read about one man's experience taking this medication to treat the inflammatory bowel disease known as ulcerative colitis.
Insurance type | Enrollees covered for Skyrizi prefilled injection pen 150 mg/1 mL | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
Affordable Care Act (ACA) plans | 99.6% | 96.6% | 88.6% |
Commercial plans (excluding ACA plans) | 99.5% | 89.9% | 84.6% |
Medicare (Medicare Advantage and Part D plans) | 98.8% | 95.4% | 83% |
Medicaid, including state-run and managed care plans | 99.6% | 81.7% | 70.6% |
Source: Managed Markets Insight & Technology, LLC™, as of August 8, 2025. (See methodology below.)
Insurance type | Enrollees covered for Skyrizi prefilled syringe, 150 mg/1 mL | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
ACA plans | 99.6% | 96.6% | 88.6% |
Commercial plans (excluding ACA plans) | 99.5% | 89.9% | 84.6% |
Medicare (original Medicare and Medicare Advantage plans) | 98.8% | 95.4% | 83% |
Medicaid, including state-run and managed care plans | 99.6% | 81.7% | 70.6% |
Source: Managed Markets Insight & Technology, LLC™, as of August 8, 2025. (See methodology below.)
Insurance type | Enrollees covered for Skyrizi on-body injector, 180 mg/1.2 mL (150 mg/mL) | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
ACA plans | 99.6% | 94.9% | 33.6% |
Commercial plans (excluding ACA plans) | 99.3% | 89.5% | 43.4% |
Medicare (original Medicare and Medicare Advantage plans) | 98.8% | 95.4% | 43.3% |
Medicaid, including state-run and managed care plans | 99.6% | 99.3% | 59.6% |
Source: Managed Markets Insight & Technology, LLC™, as of August 8, 2025. (See methodology below.)
Insurance type | Enrollees covered for Skyrizi on-body injector, 360 mg/2.4 mL (150 mg/mL) | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
ACA plans | 99.6% | 96.5% | 59.1% |
Commercial plans (excluding ACA plans) | 99.3% | 89.5% | 46% |
Medicare (original Medicare and Medicare Advantage plans) | 98.8% | 95.4% | 43.3% |
Medicaid, including state-run and managed care plans | 99.6% | 99.3% | 61.9% |
Source: Managed Markets Insight & Technology, LLC™, as of August 8, 2025. (See methodology below.)
Tips if your medication isn’t covered by insurance
If your insurance doesn’t cover Skyrizi, you still have options:
Use a GoodRx coupon to potentially save on your prescription.
Ask your prescriber about less costly options that meet your needs. This could mean switching to another brand-name medication that costs less or a medication that has a generic or biosimilar option available. (Skyrizi has no biosimilars currently approved in the U.S.)
Request a formulary exception from your insurance company. If your request is denied, you have the right to file an appeal with your plan.
When it’s time for open enrollment, compare health insurance plans to find one that provides coverage for your medications.
Ways to save on Skyrizi
Whether or not you have insurance, there are ways to reduce the cost of Skyrizi. Here are four options.
1. Use a GoodRx coupon
You may be able to use a free GoodRx coupon to lower the price of your Skyrizi prescription. For example, without insurance, you could pay as low as $23780.67 for a 150 mg/mL Skyrizi prefilled injection pen with a GoodRx coupon at certain pharmacies. Visit www.goodrx.com, or download the GoodRx app on your mobile device, and use a coupon today. Here’s how:
On the app or website, type “Skyrizi” in the search field.
Choose the desired dose, dosage form, and quantity. Input your ZIP code or address, or select “Use my current location,” so you see results for local pharmacies.
Choose how to receive your coupon. You may want it emailed or texted to you, or you may want to print it out.
Show your coupon to the pharmacy when you fill your prescripton. If you are able to pick up your Skyrizi in person, present the coupon to the pharmacy’s staff early in the filling process to help avoid delays at the counter.
It’s worth checking the GoodRx website or app to see if there are available savings on Skyrizi at your specialty pharmacy. With a free GoodRx coupon, you could pay the following price for your prescription.
GoodRx prices for Skyrizi
Brand-name form and dose | GoodRx price (as low as) |
|---|---|
Prefilled injection pen, 150 mg/mL | |
Prefilled syringe, 150 mg/mL | |
On-body injector kit (prefilled cartridge), 180 mg/1.2 mL (150 mg/mL) | |
On-body injector kit (prefilled cartridge), 360 mg/2.4 mL (150 mg/mL) |
2. See if you qualify for a copay savings card
AbbVie, the manufacturer of Skyrizi, offers several support solutions to help reduce your out-of-pocket costs. If you have commercial insurance, you may be able to benefit from a manufacturer copay savings card. You could pay as little as $0 per treatment through the Skyrizi Complete program, which can reimburse you for out-of-pocket costs if your discount isn’t processed or applied at the pharmacy. If you receive Skyrizi as an IV infusion, there’s a $1,000 maximum annual benefit for infusion-related costs available through this program. There is also a $1,000 maximum annual benefit for lab tests related to treatment.
If you’re enrolled in the Skyrizi Complete program and your discount doesn’t get processed or applied at the pharmacy or infusion center, you can request a rebate electronically for your out-of-pocket costs. You can submit receipts online or through the company's Complete app. You can add eligible administration and lab test costs to the rebate request if you received a Skyrizi infusion. After you sign up for Skyrizi Complete, you’ll be contacted by a nurse ambassador who can help you navigate your savings options.
If your insurance participates in copay adjustment through a copay accumulator or a copay maximizer program, you may be subject to savings limits per dose, per month, and/or annually as a way to ensure the savings accrue to you and not your health plan. Your copay assistance could be limited to anywhere from $4,000 to $14,000 in a calendar year. Contact your plan to find out how the Skyrizi copay assistance will work with your prescription coverage.
Copay adjustment programs are how pharmacy benefit managers and insurance companies credit the discounts offered by copay cards in ways that ensure prescription plans get the most benefit from their use. It’s important to note that copay adjustment programs require consumers to have some out-of-pocket costs. Here’s how these programs are deployed:
Copay accumulator programs: The copay annual maximum value is applied up front so health plans derive some consumer out-of-pocket spending during the coverage year. Plans also don’t credit the manufacturer copay assistance toward an enrollee’s annual deductible or, in many cases, out-of-pocket maximum, so consumers end up with some costs.
Copay maximizer programs: The annual maximum value of a copay card is applied evenly throughout the year. This may leave enrollees with little-to-no cost-sharing, and it allows plans to capture the most benefit possible from coupons.
You don’t qualify for the copay savings card if you have government-sponsored insurance, such as Medicare, Medicaid, or Tricare, or rely on a state patient assistance program or State Pharmaceutical Assistance Program. If you have questions about your eligibility, you can call 1-866-759-7494 for assistance.
In addition, specialty pharmacies often have staff members who can help you navigate programs and eligibility.
3. See if you qualify for a patient assistance program
The myAbbVie Assist program helps people living in the U.S., including U.S. territories, receive free Skyrizi if they have limited insurance or no insurance. You may qualify if you meet income requirements and have trouble affording your medication. Medicare Part D enrollees must show that they have been denied eligibility for the Extra Help low-income subsidy.
You may also be able to get help through other patient assistance programs. If you’re covered by Medicare, the Patient Access Network (PAN) Foundation offers grants to pay treatment costs for people who have a demonstrated need for financial support. The PAN Foundation has an inflammatory bowel disease fund that will help cover up to $4,000 annually in Skyrizi out-of-pocket costs. At publication time, this fund was not accepting new or renewal enrollees, but you can join the wait list.
4. Tap into your HSA, FSA, or HRA
Consider using a flexible spending account (FSA), health savings account (HSA), or health reimbursement arrangement (HRA) to pay for your medication. You can enjoy multiple tax benefits when funds from an FSA, HSA, or HRA are used to pay for qualified healthcare expenses. This can reduce your out-of-pocket costs through tax savings. But be sure to review your account’s contribution limits, rollover limits, and eligible expenses.
The bottom line
Skyrizi (risankizumab-rzaa) is an FDA-approved specialty biologic medication for managing certain types of plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. The manufacturer’s reported list price for Skyrizi’s was $22,383.49 per dose as of January 2025. There is no biosimilar version of this medication approved in the U.S.
Without insurance, the average price of a single 150 mg/mL Skyrizi prefilled injection pen is $33083.60, but you could pay as little as $23780.67 with a GoodRx coupon at select pharmacies.
If you have commercial insurance and use the manufacturer’s Skyrizi Complete copay savings card, your out-of-pocket costs could be as little as $0 per treatment. If you are uninsured, have limited insurance, or have Medicare Part D and have trouble affording your medication, you may be able to get Skyrizi at no cost through the myAbbvie Assist patient assistance program.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of August 2025.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
AbbVie. (n.d.). Skyrizi cost and savings.
AbbVie. (n.d.). Ways to save on Skyrizi.
Andrews, M. (2018). Why some patients getting drugmakers' help are paying more. NPR.
Cavalier, D., et al. (2023). Patient perceptions of copay card utilization and policies. Journal of Market Access & Health Policy.
Long, M., et al. (2024). Copay adjustment programs: What are they and what do they mean for consumers? KFF.
Medicaid.gov. (n.d.). Managed care.
Patient Access Network Foundation. (n.d.). Inflammatory bowel disease.
