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Kineret

anakinra
Used for Rheumatoid Arthritis, Autoinflammatory Syndromes
Used for Rheumatoid Arthritis, Autoinflammatory Syndromes

Kineret (anakinra) is an injectable medication used to treat rheumatoid arthritis (RA) when certain other medications haven't worked well. Kineret (anakinra) is unique in that it's the only FDA-approved RA medication that blocks a specific protein called interleukin-1 (IL-1) that's responsible for swelling and pain. Kineret (anakinra) can also be used to treat certain other auto-inflammatory conditions. It's injected under the skin, typically once daily.

In November of 2022, Kineret (anakinra) received Emergency Use Authorization (EUA) from the FDA to improve survival and shorten hospital stay for certain people hospitalized with coronavirus disease 19 (COVID-19).

Last reviewed on February 16, 2023
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What is Kineret (anakinra)?

What is Kineret (anakinra) used for?

How Kineret (anakinra) works

Kineret (anakinra) is known as a biologic disease-modifying anti-rheumatic drug (DMARD). Specifically, it blocks a protein called interleukin-1 (IL-1). This is one of the proteins that cause inflammation.

Drug Facts

Common BrandsKineret
Drug ClassBiologic DMARD
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Kineret (anakinra)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

RA:
  • Injection-site reactions (71%)
  • Sore throat, runny nose, and other symptoms of an infection (up to 39%)
  • Headache (12%)
  • Nausea (8%)
  • Diarrhea (7%)
NOMID:
  • Injection-site reactions (16%)
  • Headache (14%)
  • Vomiting (14%)
  • Joint stiffness (12%)
  • Fever (12%)
  • Runny nose and sore throat (12%)
Please note: The safety profile of Kineret (anakinra) in people treated for DIRA is similar to that of for NOMID.

Other Side Effects

RA:
  • Joint stiffness
  • Chills, body aches, and other flu-like symptoms
  • Stomach pain
NOMID:
  • Cough, congestion, and other symptoms of an upper respiratory tract infection
  • Rash

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infections: fever, tiredness, chills, cough, trouble breathing
  • Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Diarrhea

fever or chills

headache

itching, pain, redness, swelling, tenderness or warmth on the skin

joint pain

muscle aches and pains

nausea or vomiting

runny nose or sneezing

sore throat

stomach pain

Less common

Difficulty with swallowing

hives, itching, or rash

swelling of the face or lips

unusual bruising or bleeding

unusual tiredness or weakness

Incidence not known

Black, tarry stools

bleeding gums

blood in the urine or stools

dizziness

fast heartbeat

hives or welts

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

difficulty with moving

headache

muscle aches or stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Kineret (anakinra)

thumbs-up

Pros

Available as a prefilled syringe for easier administration

Injection can be given at home after proper training (but not for COVID-19)

Typically given once daily

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Cons

Needs to be injected, not good for people who don't like needles

Can weaken the immune system and raise the risk for infections

Can take a month or more to see noticeable improvements in symptoms for RA

pharmacist-tips

Pharmacist tips for Kineret (anakinra)

pharmacist
  • Your provider will likely have you give yourself your first dose of Kineret (anakinra) in their office or clinic to make sure you know how to give yourself the medication correctly. Refer to the instructions for use and contact your provider or pharmacist if you have any questions.

    • Store Kineret (anakinra) in the refrigerator and in its original packaging to protect it from light. When it's time for your dose, take a prefilled syringe out of the refrigerator and lay it on a flat surface to warm up to room temperature. This will take about 30 minutes. Don't try to warm up the medication any other way (e.g., microwave, under hot water) because you might damage it.

      • Before you inject Kineret (anakinra), always check to make sure the liquid is clear and colorless. If your medication is cloudy, discolored, or has chunks in it, don't use it. Contact your provider or pharmacist to get a replacement.

        • Inject Kineret (anakinra) under the skin in the front of your middle thighs, lower part of your stomach, upper outer areas of the buttocks, or your outer upper arms if someone else is giving you the injection. If you choose to inject into the stomach, inject 2 inches away from your belly button. Never inject into a muscle or vein.

          • To lower the risk of bruising and irritation, rotate between different injection sites each time so that the same area isn't used repeatedly. Don't inject Kineret (anakinra) into skin that's tender, red, bruised, swollen, hard, or has scars or stretch marks.

            • After giving yourself the medication, throw away the syringe and needle in a sharps container or something made of heavy-duty plastic (e.g., empty milk carton, laundry detergent bottle) to lower the risk of needlestick injuries. Don't throw away the syringe or needle in your trash can.

              • Each Kineret (anakinra) prefilled syringe provides a single dose of medication. You must throw away any leftover medication after each use, even if there's still some remaining in the syringe.

                faqs

                Frequently asked questions about Kineret (anakinra)

                How long does it take for Kineret (anakinra) to work for my rheumatoid arthritis (RA)?
                A study showed Kineret (anakinra) can start to improve symptoms of RA in about 1 month. But in clinical trials, most people felt improvement in their RA symptoms within the first 3 months of starting Kineret (anakinra). If you still don't feel better after using Kineret (anakinra) for 3 months, contact your provider.
                Can I receive vaccines if I'm taking Kineret (anakinra)?
                Ask your provider before you receive any vaccines while taking Kineret (anakinra). There's limited research about how Kineret (anakinra) might affect the way vaccines work. Data shows that this medication isn't likely to affect inactive vaccines. But because Kineret (anakinra) weakens your immune system, there's a risk that you can get sick from live vaccines. Examples of live vaccines include the FluMist Quadrivalent (live-attenuated influenza vaccine) nasal spray and the measles, mumps, rubella (MMR) vaccine. Check with your provider to make sure you're up-to-date with all vaccines before starting Kineret (anakinra).
                Can I use Kineret (anakinra) if I'm pregnant?
                There's limited research regarding whether Kineret (anakinra) is safe to take during pregnancy. Available data shows that Kineret (anakinra) didn't cause harm to mother or unborn baby during pregnancy. If you're pregnant or thinking of getting pregnant, talk to your provider about the risks and benefits of using Kineret (anakinra).
                Can I use Kineret (anakinra) if I'm breastfeeding?
                There's limited information about how Kineret (anakinra) might affect breastfeeding. Data shows this medication didn't cause obvious side effects in breastfed babies. But to be safe, don't breastfeed your baby while taking Kineret (anakinra) without talking to your provider first.
                Can Kineret (anakinra) treat coronavirus disease 2019 (COVID-19)?
                In November 2022, the FDA issued an emergency use authorization (EUA) allowing for the use of Kineret (anakinra) in hospitalized people with COVID-19 and pneumonia who are receiving oxygen and are at risk for respiratory failure. This EUA was based on a study that showed Kineret (anakinra) improved survival with shorter hospital stay for people with COVID-19. Refer to the fact sheet for more information on Kineret (anakinra) and its use to treat COVID-19. It's important to note that the EUA only allows Kineret (anakinra) to be used in people with COVID-19 who are in the hospital, so your provider can't prescribe it to you to use at home.
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                warings-icon

                What are the risks and warnings for Kineret (anakinra)?

                Kineret (anakinra) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Risk of serious infections

                • Risk factors: Active, chronic (long-term), or recurrent infection | Other conditions that raise your risk of infection | Taking medications that weaken your immune system

                  Kineret (anakinra) can make it more difficult for your body to fight off infections. This raises your risk of bacterial, viral, or fungal infections. The risk is higher for people who are taking or have recently taken other medications that weaken the immune system. Additionally, Kineret (anakinra) might reactivate (wake up) certain viruses that are already in your body, such as tuberculosis (TB), which can be dangerous. If you develop an infection, your provider will likely ask you to stop taking Kineret (anakinra) until your body fights off the infection. Let your provider know if you experience symptoms of these infections, such as fever, cough, difficulty breathing, or weakness.

                  Kineret (anakinra) can sometimes cause your neutrophil (a type of white blood cell) count to drop. A low neutrophil count means your immune system might have more trouble fighting off an infection. Your provider will likely order blood work to check your neutrophil count before you start Kineret (anakinra). They'll continue to do so monthly during your first 3 months of treatment, and then every 3 months after that for up to a year.

                  risk-warning

                  Severe allergic reactions

                  • Risk factors: DIRA

                    Severe allergic reactions to Kineret (anakinra) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). The risk of an allergic reaction is higher for people who are being treated for DIRA, especially during the first few weeks after starting Kineret (anakinra). If you notice dizziness, a choking sensation, nausea, swelling around your eyes, swelling of the lips or tongue, or difficulty breathing after using Kineret (anakinra), get medical attention right away.

                    risk-warning

                    Vaccines

                    There's limited information available on the effects of Kineret (anakinra) on your body's response to vaccines, including live vaccines. Make sure your shots are up-to-date before starting Kineret (anakinra). Talk with your provider before you receive any vaccines while receiving Kineret (anakinra) treatment. Avoid getting live vaccines while you're taking Kineret (anakinra) because there's a risk that you can get sick from them.

                    dosage

                    Kineret (anakinra) dosage forms

                    Typical dosing for Kineret (anakinra)

                    • Rheumatoid arthritis: The typical dose is 100 mg injected under the skin once daily at the same time every day.

                    • NOMID and DIRA: Your child's healthcare provider will determine their dose based on your child's body weight. The typical starting dose is 1 mg/kg to 2 mg/kg daily, given as an injection under the skin either once daily, or split into 2 smaller doses and given twice daily. Your child's provider might raise their dose over time. The maximum dose is 8 mg/kg daily.

                    interactions

                    Interactions between Kineret (anakinra) and other drugs

                    Kineret (anakinra) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Kineret (anakinra). Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    • Abatacept
                    • Adalimumab
                    • Certolizumab Pegol
                    • Etanercept
                    • Golimumab
                    • Infliximab
                    • Rilonacept
                    • Tofacitinib
                    contraindications-icon

                    Kineret (anakinra) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Kineret (anakinra) will not be safe for you to take.
                    • Allergy to E. coli-derived proteins

                    alternatives

                    What are alternatives to Kineret (anakinra)?

                    There are a number of medications that your doctor can prescribe in place of Kineret (anakinra). Compare a few possible alternatives below.
                    Used for:
                    • Rheumatoid arthritis (RA)

                    • Plaque psoriasis (PsO) and psoriatic arthritis (PsA)

                    • Ankylosing spondylitis (AS)

                    • Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

                    $8034.48 Lowest GoodRx priceView Prices
                    Used for:
                    $5863.74 Lowest GoodRx priceView Prices

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                    References

                    Best studies we found

                    Centers for Disease Control and Prevention. (2022). Live attenuated influenza vaccine [LAIV] (the nasal spray flu vaccine).

                    Chee, C. C. (2022). Emergency Use Authorization 109. U.S. Food and Drug Administration. 

                    Drugs and Lactation Database (LactMed). (2023). Anakinra. National Institute of Child Health and Human Development.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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