Key takeaways
Methocarbamol (Robaxin) and tizanidine (Zanaflex) are both medications used to treat muscle-related issues and are referred to as muscle relaxers, but they work in slightly different ways. Methocarbamol is a muscle relaxer, while tizanidine is a specific type of muscle relaxer called an alpha-2 adrenergic receptor agonist. Methocarbamol is used for muscle pain and discomfort, and its injection form is specifically indicated for muscle problems due to tetanus (only administered by a healthcare professional). Tizanidine is used for muscle stiffness and rigidity. Methocarbamol is typically taken 3 to 4 times a day, whereas tizanidine is taken up to 3 times a day as needed. Methocarbamol is not available as a brand-name tablet anymore, while tizanidine is available in both brand and generic forms. Common side effects of methocarbamol include dizziness and drowsiness, while tizanidine can cause dry mouth, sleepiness, and low blood pressure. Neither methocarbamol nor tizanidine have known interactions with common pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil, Motrin).
