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Compare Tramadol vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tramadol (Conzip, Qdolo) and oxycodone (Roxicodone, Oxycontin) are prescription opioids. They’re used to treat pain that isn't relieved by non-opioid pain medications. They work in similar ways to reduce pain, but tramadol also affects other chemicals — including serotonin, which can also contribute to pain relief. Oxycodone and tramadol have similar side effects, such as drowsiness, dizziness, and constipation. But tramadol can also increase your risk of seizures and serotonin syndrome moreso than oxycodone. Additionally, both are controlled substances that can lead to dependence and misuse, as well as overdose. If you or a loved one take tramadol or oxycodone, it’s best to carry naloxone (Narcan) with you at all times. This can rapidly reverse the effects of an overdose, if needed.

drug combination

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  • Tramadol
    Oxycodone
  • Tramadol
    Oxycodone

  • Summary of Tramadol vs. Oxycodone

    Summary for Opioid
    Prescription only

    Tramadol is an opioid pain medication used when non-opioid medications aren't working well enough to control pain. Compared to other opioids, tramadol might have a lower risk of misuse and dependency. But tramadol is a controlled substance and has a lot of potentially serious risks, so it must be used with caution.

    Summary for Opioid
    Prescription only

    Immediate-release oxycodone, also known by its brand names Roxicodone and Oxaydo, is an opioid. It's used to treat pain that isn't relieved by non-opioid pain medications. Immediate-release oxycodone is available as tablets, capsules, and a liquid that are taken by mouth. Your prescriber will work with you to find the dosage for your individual needs, but it's typically taken every 4 to 6 hours as needed for your pain. Common side effects include making you constipated, sleepy, and dizzy. Oxycodone is a controlled substance because it has a high risk of misuse and dependence.

  • Indications of Tramadol vs. Oxycodone

    Indications for
    •Pain that isn't relieved by non-opioid pain medications alone
    Indications for
    •Pain that isn't relieved by non-opioid pain medications alone

  • Pros and Cons of Tramadol vs. Oxycodone

    Pros and Const for Opioid
    Pros
    •Extended-release tablets and ConZip capsules are taken once per day and last throughout the day.
    •Immediate-release tablets are available as a lower-cost generic.
    •Possible lower risk of misuse and dependency compared to other opioids
    Cons
    •A controlled medication, so there are special requirements to get a prescription filled
    •Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms
    •Can't use in some children due to higher risk of potentially severe and life-threatening side effects
    •Not recommended while breastfeeding
    Pros and Const for Opioid
    Pros
    •Immediate-release oxycodone can start to relieve pain within 30 minutes
    •Available as a lower-cost generic (except Oxaydo)
    Cons
    •High risk of misuse, dependence, and addiction
    •Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms
    •Have special requirements to fill a prescription for it because it's a controlled substance

  • Common Side Effects of Tramadol vs. Oxycodone

    Common Side Effects for
    •Constipation (up to 46%)
    •Nausea (up to 40%)
    •Dizziness (up to 33%)
    •Headache (up to 32%)
    •Sleepiness (up to 25%)
    •Vomiting (up to 17%)
    Common Side Effects for
    •Nausea
    •Constipation
    •Vomiting
    •Itching
    •Headache
    •Dizziness
    •Weakness
    •Sleepiness
    •Trouble sleeping

  • Warnings of Tramadol vs. Oxycodone

    Common Side Effects for
    •Potential for addiction and misuse
    •Dangerously slow breathing (respiratory depression)
    •Overdose
    •Harm to newborn babies
    •Drug interactions
    •Difficulty concentrating and extreme sleepiness
    •Serotonin syndrome
    •Seizures
    •Low blood pressure
    •Low adrenal hormone levels
    •Physical dependence and withdrawal
    •Low blood sodium levels
    Common Side Effects for
    •Potential for addiction and misuse
    •Dangerously slow breathing (respiratory depression)
    •Risk for opioid overdose
    •Difficulty concentrating and extreme sleepiness
    •Drug interactions
    •Harm to newborn babies
    •Physical dependence and withdrawal
    •Low blood pressure
    •Low adrenal hormone levels
    •Seizures

  • Prices with our coupons for Tramadol vs. Oxycodone

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