Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Buprenex (buprenorphine) and Roxicodone (oxycodone) are both opioids used to treat severe pain, but they have some key differences. Buprenex is an injectable medication typically used in hospitals for people who can't use other pain treatments, while Roxicodone is an immediate-release oral medication taken by mouth. Buprenex is a partial opioid agonist, meaning it attaches to opioid receptors in the brain but less strongly than full agonists, which helps reduce the risk of a "high." In contrast, Roxicodone is a full opioid agonist that attaches strongly to mu-opioid receptors, providing quick pain relief within 10 to 30 minutes. Buprenex is a Schedule III controlled substance, indicating a lower potential for abuse compared to Roxicodone, which is a Schedule II controlled substance with a higher risk of misuse and dependence. Both medications can cause serious side effects like dangerously slow breathing and addiction, heart rhythm problems, and constipation, and both require careful management to avoid withdrawal symptoms.
Buprenorphine (Buprenex)
Oxycodone
Buprenorphine (Buprenex)
Oxycodone
Summary of Buprenex vs. Oxycodone
Summary for Opioid partial agonist
Prescription only
Buprenorphine (Buprenex) is an injectable medication that's typically given to people in the hospital for pain. It's usually reserved for people who can't use alternative treatment options, or when other pain medications aren't working.
Summary for Opioid
Prescription only
Immediate-release oxycodone, also known by its brand names Roxicodone and Oxaydo, is an opioid. It's used to treat pain that isn't relieved by non-opioid pain medications. Immediate-release oxycodone is available as tablets, capsules, and a liquid that are taken by mouth. Your prescriber will work with you to find the dosage for your individual needs, but it's typically taken every 4 to 6 hours as needed for your pain. Common side effects include making you constipated, sleepy, and dizzy. Oxycodone is a controlled substance because it has a high risk of misuse and dependence.
Indications of Buprenex vs. Oxycodone
Indications for
•Severe pain for which non-opioid pain medications aren't recommended