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Compare Cyclobenzaprine vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cyclobenzaprine (Flexeril) and oxycodone (Roxicodone, Oxaydo) are both medications used to manage pain, but they belong to different classes and have distinct uses. Cyclobenzaprine is a muscle relaxant that helps relieve muscle spasms and discomfort, while oxycodone is an opioid used for pain that isn't relieved by non-opioid medications. Cyclobenzaprine is available as immediate-release tablets and extended-release capsules, and it's typically taken for short-term use, up to 2 to 3 weeks. Oxycodone, on the other hand, is available as immediate-release tablets, capsules, and liquid, and is taken every 4 to 6 hours as needed. Cyclobenzaprine is not a controlled substance, whereas oxycodone is a Schedule II controlled substance due to its high risk of misuse and dependence. Common side effects of cyclobenzaprine include drowsiness and dry mouth, while oxycodone can cause constipation, nausea, and dizziness. Both medications can cause drowsiness, so you should avoid alcohol and be cautious with activities that require focus. Both medications can interact with antidepressants, leading to serotonin syndrome, and medications that cause drowsiness, increasing the risk of dangerous side effects.

  • Cyclobenzaprine
    Oxycodone
  • Cyclobenzaprine
    Oxycodone

  • Summary of Cyclobenzaprine vs. Oxycodone

    Summary for Muscle relaxant
    Prescription only

    Cyclobenzaprine is a muscle relaxant that helps relieve muscle pain and discomfort. It's often used short term with rest and physical therapy. Immediate-release tablets are for people 15 years and older and are taken a few times a day. Once sold under the brand name Flexeril, the tablets now as a generic and brand name Fexmid. Extended-release capsules are for adults only and are taken once a day. The capsules comes as a generic and brand name Amrix. Cyclobenzaprine can make you sleepy and have dry mouth as side effects.

    Summary for Opioid
    Prescription only

    Immediate-release oxycodone, also known by its brand names Roxicodone and Oxaydo, is an opioid. It's used to treat pain that isn't relieved by non-opioid pain medications. Immediate-release oxycodone is available as tablets, capsules, and a liquid that are taken by mouth. Your prescriber will work with you to find the dosage for your individual needs, but it's typically taken every 4 to 6 hours as needed for your pain. Common side effects include making you constipated, sleepy, and dizzy. Oxycodone is a controlled substance because it has a high risk of misuse and dependence.

  • Indications of Cyclobenzaprine vs. Oxycodone

    Indications for
    •Muscle discomfort from short-term muscle or bone injury problems
    Indications for
    •Pain that isn't relieved by non-opioid pain medications alone

  • Pros and Cons of Cyclobenzaprine vs. Oxycodone

    Pros and Const for Muscle relaxant
    Pros
    •Can take with or without food
    •Available as short-acting and long-acting forms for flexible dosing schedules
    •Can help with recovery from acute painful muscle problems in a few days
    Cons
    •Only meant for short-term use (up to 2 to 3 weeks at a time)
    •Might not be a safe option for older adults
    •Not known to work well for nerve pain or muscle spasms caused by brain or spinal injuries
    Pros and Const for Opioid
    Pros
    •Immediate-release oxycodone can start to relieve pain within 30 minutes
    •Available as a lower-cost generic (except Oxaydo)
    Cons
    •High risk of misuse, dependence, and addiction
    •Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms
    •Have special requirements to fill a prescription for it because it's a controlled substance

  • Common Side Effects of Cyclobenzaprine vs. Oxycodone

    Common Side Effects for

    Immediate-release tablets:

    •Drowsiness (39%)
    •Dry mouth (27%)
    •Dizziness (11%)

    Extended-release capsules:

    •Dry mouth (14%)
    •Dizziness (6%)
    Common Side Effects for
    •Nausea
    •Constipation
    •Vomiting
    •Itching
    •Headache
    •Dizziness
    •Weakness
    •Sleepiness
    •Trouble sleeping

  • Warnings of Cyclobenzaprine vs. Oxycodone

    Common Side Effects for
    •Serotonin syndrome
    •Effect on driving and concentration
    •Caution use in people with glaucoma or trouble urinating
    •Caution use in people with liver problems
    Common Side Effects for
    •Potential for addiction and misuse
    •Dangerously slow breathing (respiratory depression)
    •Risk for opioid overdose
    •Difficulty concentrating and extreme sleepiness
    •Drug interactions
    •Harm to newborn babies
    •Physical dependence and withdrawal
    •Low blood pressure
    •Low adrenal hormone levels
    •Seizures

  • Prices with our coupons for Cyclobenzaprine vs. Oxycodone

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