Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Cyclobenzaprine (Flexeril) and oxycodone (Roxicodone, Oxaydo) are both medications used to manage pain, but they belong to different classes and have distinct uses. Cyclobenzaprine is a muscle relaxant that helps relieve muscle spasms and discomfort, while oxycodone is an opioid used for pain that isn't relieved by non-opioid medications. Cyclobenzaprine is available as immediate-release tablets and extended-release capsules, and it's typically taken for short-term use, up to 2 to 3 weeks. Oxycodone, on the other hand, is available as immediate-release tablets, capsules, and liquid, and is taken every 4 to 6 hours as needed. Cyclobenzaprine is not a controlled substance, whereas oxycodone is a Schedule II controlled substance due to its high risk of misuse and dependence. Common side effects of cyclobenzaprine include drowsiness and dry mouth, while oxycodone can cause constipation, nausea, and dizziness. Both medications can cause drowsiness, so you should avoid alcohol and be cautious with activities that require focus. Both medications can interact with antidepressants, leading to serotonin syndrome, and medications that cause drowsiness, increasing the risk of dangerous side effects.
Cyclobenzaprine
Oxycodone
Cyclobenzaprine
Oxycodone
Summary of Cyclobenzaprine vs. Oxycodone
Summary for Muscle relaxant
Prescription only
Cyclobenzaprine is a muscle relaxant used in addition to rest and physical therapy to treat muscle pain and discomfort. It's available as an immediate-release (IR) tablet and an extended-release (ER) capsule. Unlike other muscle relaxants, it's not considered a controlled substance. Cyclobenzaprine can make you sleepy as a side effect so it's best to avoid alcohol to prevent serious harm from combining the two together.
Summary for Opioid
Prescription only
Immediate-release oxycodone, also known by its brand names Roxicodone and Oxaydo, is an opioid. It's used to treat pain that isn't relieved by non-opioid pain medications. Immediate-release oxycodone is available as tablets, capsules, and a liquid that are taken by mouth. Your prescriber will work with you to find the dosage for your individual needs, but it's typically taken every 4 to 6 hours as needed for your pain. Common side effects include making you constipated, sleepy, and dizzy. Oxycodone is a controlled substance because it has a high risk of misuse and dependence.
Indications of Cyclobenzaprine vs. Oxycodone
Indications for
•Muscle discomfort caused by acute (not long-term) conditions