Key takeaways
Oxycodone (Roxicodone, Oxycontin) and methadone (Methadose) are prescription opioids that treat severe pain that isn't relieved by non-opioid pain medications. Unlike oxycodone, methadone is also approved to treat opioid use disorder. Methadone is a long-acting medication, while oxycodone is available as a short-acting and long-acting product. All opioids are controlled substances and have side effects that include sleepiness, dizziness, and constipation. More seriously, both oxycodone and methadone can lead to potential misuse and overdose.
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