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Compare Buprenex vs. ReVia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Buprenorphine (Buprenex) and naltrexone (ReVia) are both used in the context of opioid-related conditions, but they serve different purposes and belong to different medication classes. Buprenorphine is an injectable medication used primarily for severe pain management in hospital settings, while naltrexone is an opioid antagonist used to treat opioid use disorder and alcohol use disorder. Buprenorphine is administered as an injection and is a Schedule III controlled substance due to its potential for dependence and abuse. In contrast, naltrexone is taken orally as a tablet and is not a controlled substance. Common side effects of buprenorphine include sleepiness, nausea, and dizziness, whereas naltrexone can cause nausea, headache, and trouble sleeping. Buprenorphine can interact with medications that slow breathing, while naltrexone requires you to stop all opioid medications before starting to avoid withdrawal symptoms.

  • Buprenorphine (Buprenex)
    Naltrexone (ReVia)
  • Buprenorphine (Buprenex)
    Naltrexone (ReVia)

  • Summary of Buprenex vs. ReVia

    Summary for Opioid partial agonist
    Prescription only

    Buprenorphine (Buprenex) is an injectable medication that's typically given to people in the hospital for pain. It's usually reserved for people who can't use alternative treatment options, or when other pain medications aren't working.

    Summary for Opioid antagonist
    Prescription only

    Naltrexone (ReVia) is an opioid antagonist. It's used to treat opioid use disorder and alcohol use disorder in adults. Naltrexone (ReVia) is just one part of a comprehensive treatment plan that should also involve psychotherapy and support groups. Naltrexone (ReVia) is a tablet that's taken by mouth, typically once daily. Some common side effects of naltrexone (ReVia) include nausea, headache, and trouble sleeping. Brand name ReVia has been discontinued; naltrexone tablet is only available as a generic medication.

  • Indications of Buprenex vs. ReVia

    Indications for
    •Severe pain for which non-opioid pain medications aren't recommended
    Indications for
    •Alcohol use disorder
    •Opioid use disorder

  • Pros and Cons of Buprenex vs. ReVia

    Pros and Const for Opioid partial agonist
    Pros
    Cons
    Pros and Const for Opioid antagonist
    Pros
    •Taken by mouth
    •Taken once daily
    •Available as a lower-cost generic
    Cons
    •Makes you more sensitive to the effects of opioids
    •Can cause sleep problems
    •Hasn't been studied in people younger than 18 years old

  • Common Side Effects of Buprenex vs. ReVia

    Common Side Effects for
    Common Side Effects for

    Alcohol use disorder

    •Nausea or vomiting (up to 10%)
    •Headache (7%)
    •Dizziness (4%)
    •Nervousness or anxiety (up to 4%)
    •Tiredness (4%)
    •Trouble sleeping (3%)

    Opioid use disorder Reported by 10% or more people during clinical trials:

    •Trouble sleeping
    •Anxiety
    •Nervousness
    •Stomach pain or cramps
    •Nausea and vomiting
    •Low energy
    •Joint and muscle pain
    •Headache

  • Warnings of Buprenex vs. ReVia

    Common Side Effects for
    •Addiction, abuse, and misuse
    •Dangerously slow breathing (respiratory depression)
    •Harm to newborns
    •Low adrenal hormone levels
    •Severely low blood pressure
    •Life-threatening heart rhythm problems (QT prolongation)
    •Serious allergic reaction
    •Stomach and intestine problems
    •Risk of seizures
    Common Side Effects for
    •More sensitive to opioids (risk of opioid overdose)
    •Opioid withdrawal
    •Liver injury
    •Risk of depression and suicidal thoughts

  • Prices with our coupons for Buprenex vs. ReVia

    Learn more about Buprenorphine
    Learn more about Naltrexone

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