Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Trolamine salicylate (Aspercreme Original) and lidocaine (Lidoderm) are both topical medications used to relieve pain, but they belong to different medication classes. Trolamine salicylate is a topical non-steroidal anti-inflammatory drug (NSAID) used for minor aches and pains like arthritis and muscle strains. Lidocaine viscous is a local anesthetic used for temporary relief of pain or discomfort from cuts, burns, and other skin conditions, as well as joint or muscle pain. Trolamine salicylate is available over-the-counter in forms like cream, spray, and foam, while lidocaine comes as a patch and is avaiable as a prescription or an OTC. Trolamine salicylate is applied up to four times a day, whereas lidocaine is applied once daily for a 12-hour period. Both medications can cause skin irritation. Lidocaine can also cause a mild burning sensation where you applied the patch.
Trolamine salicylate
Lidocaine 5% patch (Lidoderm)
Trolamine salicylate
Lidocaine 5% patch (Lidoderm)
Summary of Aspercreme Original vs. Lidoderm
Summary for Topical analgesic
Trolamine salicylate is a topical analgesic that helps relieve minor aches and pains from certain conditions, like muscle sprains and arthritis. This medication is a non-steroidal anti-inflammatory drug (NSAID) that's similar to aspirin. Trolamine salicylate can be used by people ages 12 years and older. It's applied directly to the affected areas, typically up to 4 times a day. This medication comes in different forms, such as cream, spray, and foam. Trolamine salicylate might cause skin irritation as a side effect. It's available over the counter (OTC) as brand name and lower-cost generic medications.
Summary for Local anesthetic
Prescription only
Lidocaine 5% patch (Lidoderm) is a prescription medication used to relieve nerve pain caused by a shingles infection, also called postherpetic neuralgia (PHN). It's a local anesthetic that works by numbing your nerves to help reduce pain. You apply the patch directly to the painful area of your skin once a day, and it can be worn for up to 12 hours in a 24-hour period. Common side effects include temporary skin irritation, redness, and a mild burning sensation where the patch is applied.