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Lamictal vs. Imitrex

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lamotrigine (Lamictal) and Sumatriptan (Imitrex) are both prescription medications, but they treat different conditions. Lamotrigine is an antiepileptic used to manage seizures and bipolar disorder, while Sumatriptan is a triptan used to treat migraines. Lamotrigine is available in various forms, including immediate-release and extended-release tablets, and it requires a gradual dose increase to avoid serious side effects like severe skin reactions. On the other hand, Sumatriptan is typically taken as a single dose at the onset of a migraine, with the option to take a second dose if needed, but not more than 200 mg in 24 hours. Sumatriptan works by tightening blood vessels and reducing inflammation in the brain, whereas the exact mechanism of Lamotrigine is not fully understood. Both medications have generic versions available, but they come with different side effects and risks. Lamotrigine can cause dizziness, double vision, and serious skin reactions, while Sumatriptan can lead to heart problems, serotonin syndrome, and extreme narrowing of blood vessels.

Lamotrigine

(Lamictal)

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Sumatriptan

(Imitrex)

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Summary for Lamictal

Prescription only

Lamotrigine (Lamictal) is an antiepileptic medication. The immediate-release version can treat different types of seizures as well as bipolar 1 disorder. But the extended-release version is only for seizures. Your dose depends on your age, the other medications you take, and what problem you're treating. Side effects can include dizziness, headache, and serious skin reactions. It can also cause withdrawal symptoms like seizures if you stop taking it suddenly.

Indications for Lamictal

Pros and Cons for Lamictal

Pros

  • Available in different formulations (regular immediate-release tablets, chewable tablets, quick-dissolving tablets, and extended-release tablets)
  • Can use a starter kit to help with dosing when you first start the medication
  • Approved for children of certain ages with seizures (age depends on formulation)

Cons

Common Side Effects for Lamictal

Immediate release:

  • Dizziness (38%)
  • Headache (29%)
  • Double vision (28%)
  • Problems with coordination (22%)
  • Nausea (19%)
  • Blurry vision (16%)
  • Sleepiness (14%)
  • Runny or stuffy nose (14%)
  • Sore throat (10%)
  • Rash (10%)

Extended release:

  • Dizziness (14%)
  • Nausea (7%)
  • Vomiting (6%)
  • Tremor (6%)
  • Feeling tired (6%)
  • Double vision (5%)
  • Diarrhea (5%)

Warnings for Lamictal

  • Serious skin rashes
  • Serious allergic reaction
  • Overactive immune response to the medication
  • Irregular heartbeat
  • Risk of suicidal thoughts and behavior
  • Meningitis (inflammation in the brain)
  • Withdrawal seizures
  • Possible eye problems
  • Interactions with other medications

Summary for Imitrex

Prescription only

Sumatriptan (Imitrex) is used to treat migraines with or without aura in adults. The medication is typically taken as a single dose for your migraine. But, it's possible that you can take it again 2 hours after the first dose if your migraine doesn't go away. Side effects of sumatriptan (Imitrex) include tingling or numbness of fingers or toes, feeling too warm or too cold, and fatigue. It can interact with antidepressants and other similar migraine medications. Sumatriptan (Imitrex) is available as a lower-cost generic tablet.

Indications for Imitrex

  • Treatment of migraine attacks with or without aura in adults

Pros and Cons for Imitrex

Pros

Cons

  • Can't use to prevent migraines
  • Must wait at least 2 hours after the first dose to take a second dose, if needed
  • Your migraines can get worse if you use this medication too often.
  • Unknown if it's safe or if it works well in children

Common Side Effects for Imitrex

  • Tingling or numbness of fingers or toes (3-5%)
  • Feeling too warm or too cold (2-3%)
  • Fatigue (2-3%)

Warnings for Imitrex

  • Heart problems and high blood pressure
  • Stroke or other brain injury
  • Extreme narrowing of blood vessels
  • Serotonin syndrome
  • Allergic reactions
  • Seizures

Prices with our coupons for Lamictal vs. Imitrex

Price Card Drug Icon
Lamotrigine30 tablets / 100mg
$9.00$9.00
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Sumatriptan1 dose pack / 9 tablets of 100mg
$14.09-
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