Key takeaways
Zonisamide (Zonegran) and Aptiom (eslicarbazepine) are both antiepileptic medications used to treat partial-onset seizures, but they have some key differences. Zonisamide is typically used as an add-on treatment and is not recommended for people with sulfa allergies. Aptiom can be used alone or with other seizure medications but should be avoided if you are allergic to oxcarbazepine (Trileptal). Zonisamide is approved for use in people aged 16 and older, while Aptiom can be used in children as young as 4 years old. Both medications can cause side effects like dizziness and sleepiness, but Aptiom is more likely to cause low sodium levels and liver injury. Zonisamide can lead to serious skin reactions and reduced sweating, which can increase the risk of heat stroke. Both medications are available as lower-cost generics.
