Compare Paxil vs. Desyrel

Paroxetine (Paxil) and trazodone are both medications used to treat depression, but they belong to different classes and have distinct uses and side effects. Paroxetine, available in both brand and generic forms, is a selective serotonin reuptake inhibitor (SSRI) that also treats various anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It works by increasing serotonin levels in the brain. Trazodone, on the other hand, is an atypical antidepressant known as a serotonin antagonist and reuptake inhibitor (SARI). While it is FDA-approved for depression, it is not a first-choice option and is often used off-label for insomnia. Paroxetine is typically taken once daily, whereas trazodone can be taken once or multiple times a day depending on the condition. Common side effects of paroxetine include nausea, sexual side effects, and weight gain, while trazodone often causes sleepiness, dry mouth, and dizziness. Both medications can cause withdrawal symptoms if stopped abruptly and have risks of serotonin syndrome and worsening depression. However, trazodone is noted for having fewer sexual side effects compared to paroxetine.