Compare Anafranil vs. Paxil

Clomipramine (Anafranil) and paroxetine (Paxil) are both medications used to treat mental health conditions, but they have important differences. Clomipramine is a tricyclic antidepressant (TCA), while paroxetine is a selective serotonin reuptake inhibitor (SSRI). Clomipramine is only FDA-approved for OCD, though it is sometimes used off-label for anxiety. Paroxetine, on the other hand, is FDA-approved for a variety of conditions, including OCD, depression, panic disorder, social anxiety disorder, generalized anxiety disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder. Clomipramine is available as an oral tablet and is typically started at a low dose, which can then be increased to a maximum of 250 mg per day for adults. Paroxetine is available in immediate-release and extended-release forms, with dosing varying based on the condition being treated. Both medications can cause side effects like weight gain and sexual problems as well as withdrawal symptoms if stopped suddently. Clomipramine is not a first-choice medication because of the high risk for side effects.