Key takeaways
Zoloft (sertraline) and Anafranil (clomipramine) are both medications that treat obsessive-compulsive disorder (OCD). Zoloft is a selective serotonin reuptake inhibitor (SSRI) that works by increasing serotonin levels in the brain. It's typically taken once daily and is also approved to treat depression and other mental-health conditions. Common Zoloft side effects include nausea, diarrhea, and dry mouth. Anafranil is a tricyclic antidepressant (TCA) that works by raising serotonin and norepinephrine levels in the brain. It's only approved to treat OCD, although it's sometimes prescribed off-label for other conditions. Anafranil side effects include dry mouth, drowsiness, and weight gain. Due to the risks and side effects of Anafranil, Zoloft is generally preferred as a first-choice treatment option.
