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Zoloft vs. Wellbutrin XL

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).

• Major depressive disorder (MDD)
• Obsessive-compulsive disorder (OCD)
• Panic disorder (PD)
• Post-traumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder (PMDD)
• Social anxiety disorder (SAD)

• Nausea (26%)
• Diarrhea (20%)
• Difficulty sleeping (20%)
• Dry mouth (14%)
• Sleepiness (12%)

• Worsening depression, suicidal thoughts, and unusual behavior
• Serotonin syndrome
• Risk of bleeding
• Not for use alone in bipolar disorder
• Glaucoma
• Life-threatening abnormal heart rhythm (QT prolongation)
• Low blood sodium levels

Bupropion is taken by mouth to treat depression and seasonal affective disorder (SAD). It's available as short-acting tablets that are taken two or three times a day, as well as long-acting versions that are taken once daily. Bupropion has fewer sexual side effects compared to other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, or drink alcohol regularly.

• Depression
• Seasonal affective disorder (SAD) - only bupropion HCl extended-release (Wellbutrin XL)

• Headache
• Dry mouth
• Nausea
• Trouble sleeping
• Dizziness
• Sore throat
• Constipation
• Restlessness (agitation)

• Suicidal thoughts or behavior and abnormal mood changes
• Mental health changes
• Seizures
• High blood pressure
• Extreme enthusiasm or excitement (mania)