Compare Zoloft vs. Valium

Sertraline (Zoloft) and diazepam (Valium) are both used to treat anxiety, but they belong to different medication classes and work in different ways. Zoloft is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain to help with mood and anxiety. It is taken once daily and is available in both tablet and liquid forms. Common side effects include nausea, diarrhea, and dry mouth. Valium, on the other hand, is a benzodiazepine that increases gamma-aminobutyric acid (GABA) levels to slow down brain activity. It is taken 2 to 4 times daily and comes in tablet and liquid forms as well. Valium can cause sleepiness, dizziness, and muscle weakness, and it carries a risk of misuse and dependence, making it a controlled substance. While Zoloft is less likely to cause weight gain and is considered safer during pregnancy and breastfeeding, Valium is generally not recommended for long-term use due to its potential for dependence and withdrawal symptoms.