Compare Estazolam vs. Silenor

Estazolam (formerly branded as Prosom) and doxepin (Silenor) are both used to treat insomnia, but they have some key differences. Estazolam is a benzodiazepine that helps you fall asleep and stay asleep by slowing down brain activity. It's only available as a generic and is a controlled substance due to its potential for misuse and dependence. You should only use it short-term and take it right before bed. On the other hand, Silenor is a tricyclic antidepressant that blocks histamine receptors to help you stay asleep. It is not addictive and doesn't cause withdrawal symptoms, making it a safer long-term option. Silenor is also available as a generic, but you need to take it on an empty stomach and avoid food for at least 3 hours before taking it. While both medications can cause sleepiness, Silenor is less likely to cause dependency issues compared to estazolam.