provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Trimipramine Coupon - Trimipramine 25mg capsule

trimipramine

Generic Surmontil
Used for Depression
Used for Depression

Trimipramine is taken by mouth and used to treat depression. It's not a first-choice medication because it can cause many side effects, such as dizziness, dry mouth, anxiety, or heart problems.

Last reviewed on January 13, 2022
basics-icon

What is Trimipramine?

What is Trimipramine used for?

  • Depression

How Trimipramine works

Trimipramine is a tricyclic antidepressant. The exact way that it works to treat depression is unknown. But it's thought to make your brain more sensitive to serotonin, a natural chemical in your brain. This is likely to improve mood.

Are you looking for information on imipramine (Tofranil) instead?

Drug Facts

Common BrandsSurmontil (brand no longer available)
Drug ClassTricyclic antidepressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$129.38(save 69.22%)
GoodRx discount
$39.82
See prices
basics-icon

What are the side effects of Trimipramine?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Blood pressure changes
  • Feeling of pins and needles in your arms and legs
  • Dry mouth
  • Blurred vision
  • Nausea and vomiting

Other Side Effects

  • Skin rash
  • Loss of appetite
  • Change in sex drive
  • Headache
  • Stomach cramps

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Suicidal thoughts and behaviors
  • Serotonin syndrome: high fever, sudden changes in thought, mood, and movement, or high blood pressure
  • Heart attack: new or worsening chest pain, fast or irregular heartbeat, dizziness, tiredness, clammy skin, nausea, vomiting
  • Stroke: tiredness, weakness, difficulty speaking, difficulty maintaining balance, headache, feeling confused, not able to move one side of your body

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding or bruising

blood in the urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

clay-colored stools

cold sweats

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in the ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in the frequency of urination

decreased urine output or volume

depression

difficulty in passing urine (dribbling)

difficulty with speaking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

drooling

dry mouth

false beliefs that cannot be changed by facts

fast, pounding, or irregular heartbeat or pulse

feeling of warmth

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

hostility

hyperventilation

inability to move the arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased thirst

increased urination

irritability

itching or rash

lack of coordination

lethargy

loss of appetite

loss of balance control

lower back or side pain

mood or mental changes

muscle spasm or jerking of all extremities

muscle trembling or stiffness

muscle twitching

nausea

nightmares

pain or discomfort in the arms, jaw, back, or neck

painful or difficult urination

passing urine more often

pinpoint red or purple spots on the skin

pounding in the ears

rapid weight gain

redness of the face, neck, arms, and occasionally, upper chest

restlessness

shakiness and unsteady walk

shuffling walk

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiffness of the limbs

sudden loss of consciousness

sweating

swelling of the face, ankles, legs, or hands

swollen glands

talking, feeling, and acting with excitement

trouble in holding or releasing urine

trouble sleeping

twisting movements of the body

uncontrolled movements, especially of the face, neck, and back

unpleasant breath odor

unsteadiness, awkwardness, trembling, or other problems with muscle control or coordination

unusual behavior

unusual tiredness or weakness

vomiting of blood

weakness in the arms, hands, legs, or feet

weight gain or loss

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abdominal or stomach cramps

bigger, dilated, or enlarged pupils (black part of the eye)

black tongue

bloating

decreased interest in sexual intercourse

diarrhea

difficulty having a bowel movement (stool)

disturbance of accommodation

enlargement of the breast

hair loss or thinning of the hair

heartburn

hives or welts

inability to have or keep an erection

increase in sexual ability, desire, drive, or performance

increased sensitivity of the eyes to light

increased sensitivity of the skin to sunlight

loss in sexual ability, desire, drive, or performance

pain or discomfort in the chest, upper stomach, or throat

peculiar taste

redness or other discoloration of the skin

severe sunburn

small red or purple spots on the skin

swelling of the breasts or breast soreness in both women and men

swelling of the testicles

swelling or inflammation of the mouth

swollen, painful, or tender lymph glands in the neck

unexpected milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Trimipramine

thumbs-up

Pros

Available as a lower-cost generic

Available in 3 different strengths, convenient if you need to adjust your dose

Can be taken once a day, usually before you go to bed

thumbs-down

Cons

Might not notice changes in your mood until you've taken trimipramine for several weeks

Stopping trimipramine suddenly can cause withdrawal symptoms, such as nausea, headache, and discomfort

Can cause more side effects than other medications used to treat depression

Not recommended for use for people with certain medical conditions, such as heart problems, thyroid problems, or seizures

pharmacist-tips

Pharmacist tips for Trimipramine

pharmacist
  • Trimipramine can cause a lot of side effects. To help your body get used to the medication, your provider will start you at a low dose. They'll adjust your dose if you're not getting enough benefit from the medication, as long as you don't have side effects. Let your provider or pharmacist know before you start any new medications, including over-the-counter medications or supplements, so they can make sure that it's safe.

    • Make sure your provider has a full list of the medications you take or have recently taken (within the last 2 weeks). Trimipramine can have dangerous interactions with certain medications.

      • Since trimipramine can make you sleepy, don't drive or do anything that requires concentration or focus until you know how your body reacts to it.

        • Even if you start to feel better and less depressed, you'll need to keep taking trimipramine as your provider prescribed.

          • Don't stop taking trimipramine without talking to your provider first. If you want to stop, ask your provider how to do so safely. Stopping this medication suddenly can cause withdrawal symptoms, such as headache, nausea, or discomfort.

            • Be very careful getting up if you've been sitting or lying down for a while since trimipramine can make you feel dizzy or cause you to fall.

              faqs

              Frequently asked questions about Trimipramine

              What time of day should I take trimipramine?
              If you're just starting to take trimipramine, your provider might recommend that you take your total daily dose in divided doses throughout the day. This is to help lower the risk of side effects. If you've reached a stable dose for your mood, your provider might recommend that you take your total daily dose all at once at bedtime. This is more convenient for you and also helpful because this medication can cause drowsiness. Ask your provider if you're not sure about when to take your medication.
              How quickly does trimipramine start to work?
              It can take up to 1 month after starting trimipramine before you notice your depression symptoms start to improve. Let your provider know if you're not sure whether this medication is working for you. Your provider might need to raise your dose slowly to find a dose that works for your or consider a different medication for your mood.
              Can I drink alcohol with trimipramine?
              Drinking alcohol with trimipramine isn't recommended. This can cause you to have more side effects from the medication or it can slow down your actions, which can be dangerous. Talk with your provider if you more questions about how alcohol might affect this medication.
              What if I want to stop taking trimipramine?
              You shouldn't stop taking trimipramine all of a sudden because it can cause withdrawal symptoms, such as headache, nausea, and discomfort. If you want to stop this medication, talk with your provider and they'll be able to help you do so safely and slowly over time.
              Is trimipramine safe to take while pregnant?
              Safety during human pregnancy hasn't been studied with trimipramine. But animal studies did show this medication can cause harm to babies in the womb. Talk with your provider if you're pregnant or have plans to become pregnant. They can talk with you about the risks and benefits of taking trimipramine during pregnancy and also let you know other options to treat depression during pregnancy.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Trimipramine?

              Trimipramine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Suicidal thoughts or behavior

              • Risk factors: People 24 years or younger | History of depression or other mood problems | Taking antidepressants | Starting trimipramine for the first time | Change in dose of trimipramine

                Trimipramine can raise the risk of suicidal thoughts or behavior. Watch for new or worsening depression, suicidal thoughts or behavior, especially during the first few months of treatment or when the dose changes. Let your healthcare provider know right away if you notice any unusual changes in mood or behavior while taking this medication.

                risk-warning

                Possible bipolar disorder

                Sometimes depression can be the first sign of bipolar disorder. Unfortunately, trimipramine doesn't treat bipolar and can cause a manic phase. Your provider will screen you for bipolar disorder before starting trimipramine. Let them know your full medical history and if anyone in your family has a history of bipolar disorder.

                risk-warning

                Serotonin syndrome

                • Risk factors: Taking trimipramine with tricyclic antidepressants, fentanyl, tramadol, buspirone, ADHD medications, triptan medications, or SSRI antidepressants

                  In some rare cases, taking trimipramine can lead to serotonin syndrome. Symptoms can include high fever, sudden changes in thought, mood, and movement, or high blood pressure. This is more likely to happen if you take certain medications for depression, migraines, or pain control. Tell your provider or pharmacist about all the medications you take before starting trimipramine.

                  risk-warning

                  Heart problems

                  • Risk factors: History of heart disease

                    If you have a history of heart disease, talk to your provider or pharmacist before taking trimipramine. People have had faster heartbeats or irregular heartbeats while taking trimipramine. People have also had heart attacks and strokes while on trimipramine.

                    risk-warning

                    Drowsiness or sleepiness

                    During the first few days of taking trimipramine, you might feel sleepy or drowsy. Be very careful driving or doing anything that requires concentration until you know how trimipramine affects you. This usually goes away after a few days to a week. Talk to your provider if you find the drowsiness isn't getting better, they may suggest taking your dose once a day at bedtime or they may switch you to a different medication.

                    risk-warning

                    Withdrawal symptoms

                    If you've been taking trimipramine for a while and want to stop taking it, talk to your provider first. While it's not addictive, stopping trimipramine suddenly can cause nausea, headache, and uneasiness for a few days until your body readjusts. Your provider will work with you to lessen the discomfort.

                    dosage

                    Trimipramine dosage forms

                    The average cost for 30 capsules of 25mg of Trimipramine is $39.82 with a free GoodRx coupon. This is 69.22% off the average retail price of $129.38.
                    capsule
                    Capsule
                    DosageQuantityPrice as low asPrice per unit
                    25mg30 capsules$39.82$1.33
                    50mg30 capsules$86.32$2.88
                    100mg30 capsules$80.28$2.68

                    Typical dosing for Trimipramine

                    Your dose might be lower if you're an adolescent or an older adult.

                    The typical dosing range for trimipramine is 50 mg to 150 mg by mouth daily, taken as divided doses throughout the day, or as a single dose at bedtime. The maximum daily dose is 200 mg.

                    interactions

                    Interactions between Trimipramine and other drugs

                    Trimipramine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Trimipramine. Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    • Acenocoumarol
                    • Arbutamine
                    • Atomoxetine
                    • Cannabis
                    • Dicumarol
                    • Phenprocoumon
                    • S-Adenosylmethionine
                    drug-cost

                    How much does Trimipramine cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                    contraindications-icon

                    Trimipramine contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trimipramine will not be safe for you to take.
                    • Recovering from a recent heart attack

                    • Taking trimipramine within 14 days of a monoamine oxidase inhibitor (MAOI)

                    alternatives

                    What are alternatives to Trimipramine?

                    There are a number of medications that your doctor can prescribe in place of Trimipramine. Compare a few possible alternatives below.
                    Trimipramine
                    Used for:
                    • Depression

                    $39.82 Lowest GoodRx priceView Prices
                    Used for:
                    • Depression

                    $4.00 Lowest GoodRx priceView Prices
                    Used for:
                    • Depression

                    • Bedwetting in children (imipramine hydrochloride only)

                    $23.53 Lowest GoodRx priceView Prices
                    images

                    Trimipramine images

                    Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
                    This medicine is Blue And Yellow Capsule Imprinted With "A-293 A-293".Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
                    Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule
                    This medicine is Blue And Yellow Capsule Imprinted With "A-293 A-293".Blue And Yellow A-293 A-293 - Trimipramine Maleate 25mg Capsule

                    Get savings updates for Trimipramine

                    Receive price alerts, news, and other messages from GoodRx about Trimipramine and other healthcare topics and relevant savings offers.

                    By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                    Browse medications

                    View All

                    Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.