Key takeaways
Maprotiline and trimipramine are both medications used to treat depression, but they belong to different classes. Maprotiline was a tetracyclic antidepressant, but is no longer available in the U.S. Trimipramine is a tricyclic antidepressant. Trimipramine is still available as a generic and can be taken in divided doses throughout the day or as a single dose at bedtime. Trimipramine can cause side effects like dizziness, dry mouth, and heart problems, and it may take several weeks to notice mood improvements. It also has potential interactions with other medications, especially those affecting serotonin levels.
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