Key takeaways
Vivactil (protriptyline) and Norpramin (desipramine) are both tricyclic antidepressants (TCAs) used to treat depression, but they have some differences. Vivactil (protriptyline) needs to be taken 3 to 4 times a day, while Norpramin (desipramine) is typically taken once a day. Vivactil can cause side effects like headache, blurry vision, and restlessness, whereas Norpramin can cause sleepiness, confusion, and weight gain. Both medications can cause dizziness and should be used with caution in older adults. Vivactil is not commonly used today due to its side effects and the need for multiple daily doses, while Norpramin is also not a first-choice treatment because of its many side effects. Both medications are available as lower-cost generics and can cause withdrawal symptoms if stopped abruptly.
