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Amitriptyline Coupon - Amitriptyline 25mg tablet

amitriptyline

Generic Elavil
Used for Depression, Migraine

Amitriptyline is also known by the old brand name Elavil. It's a tricyclic antidepressant (TCA) that's approved to treat depression. But it's not used as often today for depression because it can cause a lot of side effects, like sleepiness and weight gain. It also has many drug interactions. Even so, amitriptyline is often used off label for other reasons, like nerve pain from diabetes and to help prevent migraines. Amitriptyline comes as a generic tablet that you take by mouth. The brand name Elavil is no longer available.

Reviewed by:Last reviewed on February 5, 2026
basics-icon

What is Amitriptyline?

What is Amitriptyline used for?

How Amitriptyline works

Amitriptyline is a tricyclic antidepressant (TCA). It's not clear how the medication works. But it's thought to treat depression by raising levels of serotonin and norepinephrine in the brain. This can help improve your mood.

When does Amitriptyline start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Initial effect
MONTHS
Full effect

Drug facts

Common BrandsElavil(brand name no longer available)
Drug ClassTricyclic antidepressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Amitriptyline

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness
  • Dizziness
  • Weakness
  • Fatigue
  • Headache
  • Dry mouth
  • Nausea
  • Vomiting
  • Constipation
  • Weight gain

Less Common Side Effects

  • Blurry vision
  • Confusion
  • Trouble urinating
  • Skin sensitivity to sunlight
  • Hair loss
  • Low blood pressure when standing up
  • Fast heart rate or racing heart
  • Changes in sex drive
  • Erectile dysfunction

Amitriptyline serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Heart attack: chest pain, pain in the left arm, cold sweats, trouble breathing
  • Stroke: sudden headache, sudden numbness or weakness on one side of the body, droopy face, confusion, trouble talking, trouble walking
  • Serious allergic reaction: trouble breathing, tightness in the throat, hives, itching, fast heartbeat, dizziness, swelling in the face or tongue
When do Amitriptyline possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Sleepiness
Dizziness
Dry mouth
Risk of worse depression or thoughts of self-harm
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Amitriptyline side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness

changes in patterns and rhythms of speech

chest pain or discomfort

chills

cold sweats

coma

confusion

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in frequency of urination

decrease in urine volume

decreased urine output

difficulty in breathing

difficulty in passing urine (dribbling)

difficulty in speaking

disturbance of accommodation

disturbed concentration

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision

drooling

dry mouth

excitement

fainting

false beliefs that cannot be changed by facts

fast, slow, or irregular heartbeat

fear or nervousness

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

high fever

high or low blood pressure

hostility

inability to move arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased ocular pressure

increased sweating

increased thirst

increased urination

irritability

lack of coordination

lethargy

light-colored stools

lip smacking or puckering

loss of appetite

loss of balance control

loss of bladder control

loss of consciousness

lower back or side pain

mental depression or anxiety

muscle spasm or jerking of all extremities

muscle tightness

muscle trembling, jerking, or stiffness

muscle twitching

nausea and vomiting

nightmares or unusually vivid dreams

overactive reflexes

painful or difficult urination

passing urine more often

pinpoint red spots on skin

poor coordination

pounding in the ears

puffing of cheeks

rapid or worm-like movements of tongue

rapid weight gain

restlessness

seeing, hearing, or feeling things that are not there

seizures

severe muscle stiffness

shakiness and unsteady walk

shivering

shortness of breath

shuffling walk

sleeplessness

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on lips or in mouth

stiffness of limbs

stupor

sudden loss of consciousness

sweating

swelling of face, ankles, or hands

swelling or puffiness of face

swollen glands

talking or acting with excitement you cannot control

trouble in speaking

trouble sleeping

troubled breathing

twisting movements of body pain or discomfort in arms, jaw, back, or neck

unable to sleep

uncontrolled chewing movements

uncontrolled movements, especially of arms, face, neck, back, and legs

unexplained weight loss

unpleasant breath odor

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual tiredness or weakness

unusually pale skin

upper right abdominal pain

vomiting of blood

weakness in arms, hands, legs, or feet

weight gain or loss

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

Clumsiness

drowsiness

low body temperature

muscle aches

muscle weakness

sleepiness

tiredness

weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bigger, dilated, or enlarged pupils (black part of eye)

black tongue

bloating

breast enlargement in females

constipation

decreased interest in sexual intercourse

diarrhea

hair loss, thinning of hair

hives or welts

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity of eyes to light

loss in sexual ability, desire, drive, or performance

loss of sense of taste

redness or other discoloration of skin

severe sunburn

skin rash

swelling of testicles

swelling of the breasts or breast soreness in males

swelling of the parotid glands

swelling or inflammation of the mouth

unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Amitriptyline

Pros

  • Can start to work within 2 to 4 weeks
  • Can take with or without food

Cons

  • Has many unpleasant side effects, like dry mouth and sleepiness, and drug interactions
  • Not the best choice for people with heart problems, trouble urinating, or glaucoma or older adults
pharmacist-tips-icon

Pharmacist tips for Amitriptyline

pharmacist
  • You can take amitriptyline with or without food. If it upsets your stomach, try taking it with food next time. This might help calm your stomach.
  • You might start to feel better after about 2 to 4 weeks of taking amitriptyline. But it can take 1 to 2 months to feel the full effect. Keep taking amitriptyline as prescribed, even if you don't improve right away. Tell your prescriber if side effects, like sleepiness, dry mouth, or nausea, bother you too much.
  • Don't change your dose or stop taking amitriptyline suddenly without talking to your prescriber first. This can cause uncomfortable withdrawal symptoms like nausea, headaches, body aches, or sleep problems. If stopping is the right choice, your prescriber will help lower your dose slowly to prevent withdrawal symptoms.
  • Amitriptyline can make you feel tired, sleepy, and dizzy. Don't drive or do anything that needs your full attention until you know how this medication affects you. These side effects might get better as you continue to take the medication for a few weeks.
  • Amitriptyline can make your blood pressure drop when you stand up. This can make you feel dizzy or off balance, which can raise your risk of falling. Get up slowly and hold onto something steady after sitting or lying down. If you keep feeling dizzy after a few weeks or if you fall while taking amitriptyline, tell your prescriber.
  • Amitriptyline can sometimes make your skin more sensitive to the sun. This can mean that you can get sunburned more easily. When you go outside, be sure to apply sunscreen and wear protective clothing to help prevent sunburn.
  • Antidepressants like amitriptyline can raise the risk of suicidal thoughts. Call 911 right away if you or someone close to you notices unusual changes in your behavior or mood while taking this medication.
  • If you have diabetes, ask your care team if you need to check your blood sugar more often while taking amitriptyline. This medication can cause blood sugar to go up or down.
  • Tell your healthcare team about all the medications you take or plan to take. This helps them make sure your medications are safe to take together. Amitriptyline can interact with many medications and raise the risk of side effects. Taking it with anxiety medications, opioids, or some allergy medications can make you very sleepy. Monoamine oxidase inhibitors (MAOIs) can also raise the risk of a serious problem called serotonin syndrome.
  • If you're pregnant or thinking of becoming pregnant, tell your prescriber. They can talk to you about the benefits and risks of taking amitriptyline while pregnant. Note that mental health problems that aren't treated can be harmful for both you and your baby during pregnancy. Your prescriber can help find the safest option for you.
  • Let your prescriber know if you want to breastfeed. Amitriptyline can get into breast milk in small amounts. Your prescriber can explain the risks and benefits of taking this medication while breastfeeding. You can also talk to a lactation consultant about other feeding options.
Common questions about Amitriptyline

Common questions about Amitriptyline

Yes, weight gain can be a common side effect of Amitriptyline. Studies show that people can gain up to 16 pounds while taking this medication. Note that how much weight you might gain can depend on your dose and how long you've taken the medication. To help manage your weight, try to make healthful food choices and exercise regularly. If you're concerned about weight gain or notice too much weight gain, talk to your care team. They can give you more tips on how to manage your weight and provide guidance on the next steps to take.

Yes. You can have withdrawal symptoms if you stop taking Amitriptyline suddenly. Symptoms can include tiredness, dizziness, weakness, and anxiety. You might also have an upset stomach, muscle aches, stiff muscles, or trouble sleeping. In general, these symptoms happen because there's a sudden drop in serotonin in the brain after you stop the medication. It's not because of your psychological need for it. Make sure to take Amitriptyline exactly as prescribed. If you want to stop taking it, talk to your prescriber first. If it's the right choice for you, they'll lower your dose slowly so you can stop safely.

No. Amitriptyline isn't an SSRI, or a selective serotonin reuptake inhibitor. Instead, it's a tricyclic antidepressant (TCA). Both SSRIs and TCAs are types of antidepressants that can help with depression. But they work in slightly different ways and have slightly different side effects.

No, Amitriptyline isn't a controlled substance. It isn't known to have a risk of addiction. It also doesn't have a risk of misuse or dependence.

You should avoid alcohol while taking Amitriptyline. Alcohol can make side effects like dizziness and sleepiness worse. It can also sometimes lead to a blackout. What's more, alcohol can worsen feelings of depression. Talk to your prescriber about how much alcohol you usually drink. They can make sure you can take Amitriptyline safely. If it's hard for you to stop drinking, talk to your prescriber for help to quit alcohol.

Amitriptyline isn't FDA approved to help with sleep. But treatment guidelines for insomnia say that it might help people who have both trouble sleeping and depression. This is an off-label use of the medication. Don't take Amitriptyline for sleep unless it's prescribed for you for that reason. If you have trouble sleeping, talk to your primary care provider or a sleep specialist. They can help find the best treatment for you.

Sometimes. Amitriptyline is mainly used to treat depression, not anxiety. Most people take SSRIs or SNRIs first for some types of anxiety. But if those don't work well, prescribers can consider TCAs like Amitriptyline as a second-choice option. This is called an off-label use because Amitriptyline isn't FDA approved for anxiety. Don't take Amitriptyline for anxiety unless it's prescribed for you for this reason. If you have anxiety, talk to your primary care provider or a mental health specialist about treatment options.

Amitriptyline and nortriptyline (Pamelor) are very similar medications. They're both tricyclic antidepressants (TCAs) used to treat depression. In fact, after you take amitriptyline, your body turns it into nortriptyline. The main difference is their side effects. Amitriptyline might be more likely to cause sleepiness, low blood pressure, dry mouth, and trouble urinating. Another difference is that Amitriptyline only comes as tablets. But nortriptyline (Pamelor) comes as pills and a liquid. Talk to a healthcare professional to help you compare.

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Risks and warnings for Amitriptyline

Amitriptyline can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Worsening depression or suicidal thoughts and behavior

  • Risk factors: Age under 24 years old | History of depression or other mental health conditions

Black Box Warning Some people taking amitriptyline for depression might feel worse. This medication can also raise the risk of suidical thoughts or behavior. The risk is highest for people age 24 and younger.

Watch for signs like worsening depression, anxiety, panic attacks, trouble sleeping, or feeling angry or irritated. This is most important during the first few months of treatment or after a dose change. If you or someone close to you notices unusual mood or behavior changes, talk to your care team. Call 911 right away if you have thoughts of hurting yourself.

Serotonin syndrome

  • Risk factors: Taking other medications that raise serotonin levels in the brain

Amitriptyline can sometimes cause a serious and sometimes life-threatening problem called serotonin syndrome. This happens when you have too much serotonin in your brain. Amitriptyline can raise serotonin levels.

The risk is higher if you take amitriptyline with other medications that also raise serotonin levels. These include other antidepressants, cough medications with dextromethorphan, and triptans for migraines. Tell your care team about all the medications you take so they can check your risk.

Watch for a high fever, fast heart rate, heavy sweating, stiff muscles, confusion, or restlessness. These can be signs of serotonin syndrome. Stop taking amitriptyline and get medical help right away if you notice these symptoms.

Not for use alone for bipolar disorder

  • Risk factors: Personal history of bipolar disorder | Family history of bipolar disorder, depression, or suicide

Depression can sometimes be the first sign of bipolar disorder. Taking an antidepressant like amitriptyline by itself can cause a manic episode in people with bipolar disorder. A manic episode can look like lots of energy, talking rapidly, racing thoughts, and less need for sleep.

Before starting amitriptyline for depression, tell your prescriber if you or anyone in your family has bipolar disorder. They'll check your risk and make sure you get the right care. Amitriptyline isn't approved to treat bipolar depression. Get medical help right away if you or someone close to you thinks you're having a manic episode.

Risk of heart problems, heart attack, or stroke

  • Risk factors: History of heart problems | Taking high doses of amitriptyline

Before starting amitriptyline, talk to your prescriber if you have any heart problems or have had a stroke before. They can help decide if this medication is safe for you. Amitriptyline, especially at higher doses, might affect heart rhythm (arrhythmia). Some people taking tricyclic antidepressants like amitriptyline have had a heart attack or stroke.

Let your prescriber know if your heart feels like it's beating oddly while taking amitriptyline. Get medical help right away if you have chest pain, pain in your left arm, cold sweats, or trouble breathing. These can be signs of a heart attack. Also get emergency help if you have signs of a stroke. This can look like a sudden headache, weakness on one side of the body, a droopy face, confusion, or trouble speaking.

Low sodium levels

  • Risk factors: Older adults | Medical condition called syndrome of inappropriate antidiuretic hormone (SIADH) | Taking diuretics (water pills) | Dehydrated or low fluid levels in the body

Amitriptyline can sometimes lower the sodium levels in the body. Low sodium can cause headaches, trouble concentrating, memory problems, confusion, weakness, or balance problems. If you notice any of these symptoms, call your prescriber right away.

Risk of seizure

  • Risk factors: History of seizures | Taking high doses of amitriptyline

Amitriptyline might raise your risk of seizures, especially at higher doses. This is one of the reasons why you start at a low dose and why your prescriber will slowly raise the dose over time. If you've had a seizure before, talk to your prescriber to make sure amitriptyline is safe for you. If you have a seizure while taking amitriptyline, get medical help right away.

Angle-closure glaucoma in certain people

  • Risk factors: History of angle-closure glaucoma | Have narrow-angle eyes but haven't had laser eye surgery for it yet

Antidepressants like amitriptyline can sometimes cause a sudden eye problem called an angle-closure attack. This is more likely in people with narrow-angle eyes who haven't had laser eye surgery. Tell your prescriber if you've had angle-closure glaucoma before.

Call your eye specialist right away if you have signs of an angle-closure attack. This can include sudden blurry vision, severe eye pain, or see halos around lights. This is a serious eye problem that needs urgent medical care.

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Amitriptyline dosage

The average cost for 30 tablets of 25mg of Amitriptyline is $4.00 with a free GoodRx coupon. This is 0.00% off the average retail price of $4.00.
tabletTablet
DosageQuantityPrice as low asPrice per unit
10mg30 tablets$4.00$0.13
25mg30 tablets$4.00$0.13
50mg90 tablets$10.00$0.11
75mg90 tablets$10.00$0.11
100mg90 tablets$24.11$0.27
150mg30 tablets$16.13$0.54

Typical dosage for Amitriptyline

You typically start at a low dose of amitriptyline. Then, your prescriber will adjust your dose depending on how well it's working for you and if you have side effects.

For depression:

  • Adults 18 to 64 years old: The typical dose is 50 mg to 100 mg by mouth per day. The dose can be taken in smaller amounts throughout the day or all at once at bedtime. The maximum recommended dose is 150 mg per day.
  • Adults 65 years and older: The typical starting dose is 10 mg by mouth three times a day along with 20 mg at bedtime. Your prescriber will adjust the dose based on your needs.
  • Children 12 to under 18 years old: The typical starting dose is 10 mg by mouth three times a day along with 20 mg at bedtime. The prescriber will adjust the dose based on your child's needs.
interactions-icon

Interactions between Amitriptyline and other drugs

Amitriptyline may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Amitriptyline. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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Amitriptyline contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Amitriptyline will not be safe for you to take.

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What are alternatives to Amitriptyline?

There are a number of medications that your doctor can prescribe in place of Amitriptyline. Compare a few possible alternatives below.
Amitriptyline
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Amitriptyline images

Green Round M 51 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "M 51".Green Round M 51 - Amitriptyline Hydrochloride 25mg Tablet
Green Round Gg 44 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Gg 44".Green Round Gg 44 - Amitriptyline Hydrochloride 25mg Tablet
Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Ap 21".Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Ap 21".Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
Green Round 31 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "31".Green Round 31 - Amitriptyline Hydrochloride 25mg Tablet
Green Round 31 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "31".Green Round 31 - Amitriptyline Hydrochloride 25mg Tablet
Green Round Za 2 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Za 2".Green Round Za 2 - Amitriptyline Hydrochloride 25mg Tablet
Brown Round I2 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Brown, Round Tablet Imprinted With "I2".Brown Round I2 - Amitriptyline Hydrochloride 25mg Tablet
Yellow Round 420 And U - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Yellow, Round Tablet Imprinted With "420" And "U".Yellow Round 420 And U - Amitriptyline Hydrochloride 25mg Tablet
Yellow Round 420 And U - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Yellow, Round Tablet Imprinted With "420" And "U".Yellow Round 420 And U - Amitriptyline Hydrochloride 25mg Tablet
Green Round Mp 25 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Mp 25".Green Round Mp 25 - Amitriptyline Hydrochloride 25mg Tablet
Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Ap 21".Green Round Ap 21 - Amitriptyline Hydrochloride 25mg Tablet
Green Round 202 And Ls - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Ls" And "202".Green Round 202 And Ls - Amitriptyline Hydrochloride 25mg Tablet
Green Round 202 And Ls - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Green, Round Tablet Imprinted With "Ls" And "202".Green Round 202 And Ls - Amitriptyline Hydrochloride 25mg Tablet
Brown Round Logo 35 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Brown, Round Tablet Imprinted With "Logo 35".Brown Round Logo 35 - Amitriptyline Hydrochloride 25mg Tablet
Brown Round Logo 35 - Amitriptyline Hydrochloride 25mg Tablet
This medicine is Brown, Round Tablet Imprinted With "Logo 35".Brown Round Logo 35 - Amitriptyline Hydrochloride 25mg Tablet

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References

Best studies we found

Advagen Pharma Ltd. (2025). Amitriptyline hydrochloride tablet, film coated [package insert]. DailyMed.

American College of Obstetricians and Gynecologists. (2014). Depression during pregnancy.

Berken, G. H., et al. (1984). Weight gain. A side-effect of tricyclic antidepressants. Journal of Affective Disorders.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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