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Compare Relpax vs. Zomig

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Relpax (eletriptan) and Zomig (zolmitriptan) are both triptans used to treat migraines, but they have some differences. Relpax is available only as a tablet, while Zomig comes in multiple forms, including a tablet, an orally disintegrating tablet (ODT), and a nasal spray. This makes Zomig a good option if you have trouble swallowing pills during a migraine. Relpax starts working in about 30 minutes but can take 2 hours for its full effects, whereas Zomig can take up to 2 hours to relieve migraine pain. Both medications can be taken with ibuprofen or Tylenol, but you should always check with your healthcare provider first. Relpax is available as a lower-cost generic, while Zomig is available as both a brand-name and generic medication. Both medications can cause side effects like dizziness and sleepiness, but Zomig's nasal spray form can also cause an unusual taste.

  • Eletriptan (Relpax)
    Zolmitriptan (Zomig)
  • Eletriptan (Relpax)
    Zolmitriptan (Zomig)

  • Summary of Relpax vs. Zomig

    Summary for Triptan
    Prescription only

    Eletriptan, also known by its brand name Relpax, is a triptan that's a first-choice treatment option for adults who have migraine attacks with or without aura. This medication is available as a tablet that's taken by mouth at the first sign of a migraine attack. The dosage can be repeated 2 hours later if the migraine comes back or doesn't go away. Side effects include making you sleepy and dizzy. Eletriptan (Relpax) is available as a lower-cost generic.

    Summary for Triptan
    Prescription only

    Zolmitriptan (Zomig) is used for the short-term treatment of migraines. You typically take just one dose when you have a migraine. Zolmitriptan (Zomig) can cause side effects like dizziness and chest, neck, or jaw pain. This medication is a tablet that you swallow. It also comes as an orally disintegrating tablet (ODT) and a nasal spray, which can be good options for people who have trouble swallowing pills during a migraine. Zolmitriptan (Zomig) is available by prescription only as a brand-name and generic medication; it's not found over the counter.

  • Indications of Relpax vs. Zomig

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Treatment of migraine

  • Pros and Cons of Relpax vs. Zomig

    Pros and Const for Triptan
    Pros
    •Might provide migraine pain relief for a longer period of time than other triptans
    •One of the first-choice options for short-term treatment of migraines
    •Starts to work after 30 minutes
    •Available as a lower-cost, generic
    Cons
    •Only available as a tablet that's swallowed whole
    •Not recommended for people with severe liver damage
    •Not known if it's safe or works well for children
    •Not used for preventing migraines or treating other types of headaches
    Pros and Const for Triptan
    Pros
    •One of the first-choice options for adults to treat moderate or severe migraine
    •Works within 2 hours after taking the dose
    •Has ODT and nasal spray forms, so it's a good option for people who have trouble swallowing pills during a migraine
    Cons
    •Not used for other types of headaches
    •Doesn't prevent migraines from happening
    •Can worsen your headaches if you take the medication for more than 9 days in a month

  • Common Side Effects of Relpax vs. Zomig

    Common Side Effects for
    •Dizziness (up to 6%)
    •Sleepiness (up to 6%)
    •Nausea (up to 5%)
    •Body weakness (up to 5%)
    •"Pins and needles" feeling in the arms or legs (3%)
    Common Side Effects for

    Tablets and orally disintegrating tablets

    •Nausea (up to 9%)
    •Dizziness (up to 8%)
    •Pins and needles feeling in the arms or legs (up to 7%)
    •Neck, throat, or jaw pain, tightness, or pressure (up to 7%)
    •Sleepiness (up to 6%)
    •Feeling warm or cold (up to 6%)
    •Body weakness (up to 5%)
    •Dry mouth (up to 5%)
    •Chest pain, tightness, pressure, or heaviness (up to 3%)

    Nasal spray

    •Unusual taste (up to 17%)
    •Dizziness (6%)
    •Pins and needles feeling in your arms or legs (5%)
    •Throat pain (4%)
    •Feeling warm (4%)
    •Dry mouth (3%)
    •Body weakness (3%)

  • Warnings of Relpax vs. Zomig

    Common Side Effects for
    •Heart problems and high blood pressure
    •Stroke or other brain injury
    •Extreme narrowing of blood vessels
    •Worsened headaches if eletriptan (Relpax) is taken too often
    •Serotonin syndrome
    Common Side Effects for
    •Heart attack and chest pain (angina)
    •Irregular heart rhythm (arrhythmias)
    •Stroke or other brain injury
    •Blood vessel issues
    •Serotonin syndrome
    •High blood pressure
    •Caution use in people with phenylketonuria (PKU) - for orally disintegrating tablet only

  • Prices with our coupons for Relpax vs. Zomig

    Learn more about Eletriptan
    Learn more about Zolmitriptan

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