Compare Depakote vs. Abilify

Divalproex (Depakote) and aripiprazole (Abilify) are both prescription medications, but they belong to different classes and treat different conditions. Divalproex is an antiepileptic used to treat seizures, prevent migraines, and manage bipolar disorder. It works by increasing gamma-aminobutyric acid (GABA) in the brain to reduce activity bursts. Aripiprazole, on the other hand, is an atypical antipsychotic used to treat mental health conditions like schizophrenia, bipolar I disorder, and as an add-on for depression. It balances dopamine and serotonin in the brain to control thoughts, mood, and behaviors. Divalproex is available in various forms, including delayed-release and extended-release tablets, while aripiprazole comes in tablets, solutions, and orally disintegrating tablets. Both medications can cause sleepiness, but aripiprazole is less likely to cause weight gain compared to other antipsychotics, whereas divalproex can cause both weight gain and weight loss. Additionally, divalproex requires regular blood tests to monitor liver health, while aripiprazole can raise blood sugar and cholesterol levels.