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Compare Trileptal vs. Depakote

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Trileptal (oxcarbazepine) and divalproex (Depakote) are both antiepileptic medications, but they have different uses and side effects. Trileptal is mainly used to treat partial-onset seizures and is available in both immediate-release and extended-release forms (Oxtellar XR). Divalproex, on the other hand, is used for a broader range of conditions, including seizures, bipolar disorder, and migraine prevention. While Trileptal works by blocking sodium channels in the brain, divalproex increases the levels of GABA, a calming chemical in the brain. Both medications can cause dizziness and nausea, but divalproex has a higher risk of serious side effects like liver problems and pancreatitis. Both medications are available in generic forms, making them more affordable options.

  • Oxcarbazepine (Trileptal)
    Divalproex (Depakote)
  • Oxcarbazepine (Trileptal)
    Divalproex (Depakote)

  • Summary of Trileptal vs. Depakote

    Summary for Antiepileptic
    Prescription only

    Oxcarbazepine (Trileptal) is used to treat partial-onset seizures (also called focal aware seizures). This antiepileptic is for people 2 years of age and older. It helps calm the brain to keep seizures from happening. Oxcarbazepine (Trileptal) comes as immediate-release tablets and an oral suspension. You take it by mouth twice a day. Some common side effects include dizziness, nausea, and headaches. Immediate-release oxcarbazepine comes in both brand-name and generic versions. You can take it by itself or with other anti-seizure medications.

    Summary for Antiepileptic
    Prescription only

    Divalproex (Depakote) is an antiepileptic medication used to treat certain types of seizures, bipolar disorder, and prevent migraines. The medication comes as delayed-release (DR) tablets, extended-release (ER) tablets, and sprinkle capsules. You take it by mouth, either once a day or in divided doses, depending on your condition and the form that's prescribed. Common side effects include stomach pain, hair loss, and diarrhea. Serious risks include liver problems, inflammation of the pancreas, and birth defects if taken during pregnancy.

  • Indications of Trileptal vs. Depakote

    Indications for
    •Partial-onset seizures (or focal aware seizures)
    Indications for
    •Bipolar disorder
    •Seizures
    •Migraine prevention

  • Pros and Cons of Trileptal vs. Depakote

    Pros and Const for Antiepileptic
    Pros
    •Okay for children as young as 2 years old with partial-onset seizures to take
    •Available as an oral liquid for people who have trouble swallowing the tablets
    •Dose can be adjusted based on response to the medication
    Cons
    •Can make it hard to focus and react quickly
    •Can cause serious skin reactions
    •Interacts with many medications, including some antidepressants and other seizure medications
    Pros and Const for Antiepileptic
    Pros
    •Used for seizures, bipolar disorder, and migraine prevention
    •Dose is adjusted based on your response
    •Available in multiple forms
    •Can be used alone or with other medications
    Cons
    •Won't help if you have a migraine attack
    •Interacts with many medications
    •Not safe to take in pregnancy
    •Requires regular blood work and lab tests

  • Common Side Effects of Trileptal vs. Depakote

    Common Side Effects for
    •Dizziness
    •Sleepiness
    •Tiredness
    •Nausea
    •Vomiting
    •Headache
    •Trouble walking
    •Double vision
    •Other changes in vision
    •Shaky eye movements (nystagmus)

    Note: Side effects were reported by people who took oxcarbazepine (Trileptal) either by itself or with other seizure medications.

    Common Side Effects for

    Bipolar disorder

    •Sleepiness (19-26%)
    •Indigestion (9-23%)
    •Nausea (19-22%)
    •Vomiting (12-13%)
    •Dizziness (12%)
    •Accidental injury (6-11%)
    •Stomach pain (9-10%)
    •Weakness (6-10%)

    Seizures

    •Nausea (48%)
    •Headache (31%)
    •Weakness (27%)
    •Vomiting (27%)
    •Sleepiness (27%)
    •Tremor (25%)
    •Dizziness (25%)
    •Stomach pain (23%)

    Migraine

    •Nausea (15-31%)
    •Weakness (20%)
    •Sleepiness (7-17%)
    •Infection (15%)
    •Indigestion (7-13%)
    •Diarrhea (7-12%)
    •Dizziness (12%)
    •Vomiting (7-11%)

  • Warnings of Trileptal vs. Depakote

    Common Side Effects for
    •Low sodium levels
    •Severe allergic reaction
    •Serious skin reactions
    •Risk of suicidal thoughts and behavior
    •Trouble with concentration, speech, and movement
    •Higher risk of having new seizures
    •Withdrawal seizures
    Common Side Effects for
    •Liver problems
    •Birth defects
    •Inflammation of the pancreas
    •Suicidal thoughts or behavior
    •Bleeding and blood conditions
    •High ammonia levels
    •Low body temperature
    •Severe skin reactions
    •Serious allergic reaction
    •Sleepiness in older adults
    •Interaction with other medications

  • Prices with our coupons for Trileptal vs. Depakote

    Learn more about Oxcarbazepine
    Learn more about Divalproex

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