Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Gabapentin (Neurontin) and Levetiracetam (Keppra) are both antiepileptic medications, but they have some key differences. Gabapentin is used to treat certain seizures and nerve pain, while Levetiracetam is used for various types of seizures, including partial-onset, myoclonic, and generalized tonic-clonic seizures. Gabapentin is typically taken three times a day, whereas Levetiracetam can be taken once or twice daily depending on the formulation. Gabapentin is available as a lower-cost generic, and it can come in tablets, capsules, and liquid forms. Levetiracetam also has a generic version and is available in immediate-release and extended-release tablets, as well as a liquid form. Common side effects of Gabapentin include dizziness and sleepiness, while Levetiracetam can cause weakness, sleepiness, and headaches. Additionally, Gabapentin has a potential for misuse and is controlled in some states, whereas Levetiracetam is not a controlled substance. Both medications can cause serious side effects like suicidal thoughts and severe allergic reactions, but Levetiracetam may also rarely cause mood and behavior changes, especially in children.
Gabapentin (Neurontin)
Levetiracetam (Keppra)
Gabapentin (Neurontin)
Levetiracetam (Keppra)
Summary of Neurontin vs. Keppra
Summary for Antiepileptic
Prescription only
Gabapentin, also known by its brand name Neurontin, is used to treat nerve pain from shingles in adults. This medication can also help treat partial (focal) seizures in adults and children. Gabapentin (Neurontin) comes as pills and a liquid that you take by mouth. The dosage depends on things like what you're treating, how old you are, and how well the medication is working. In general, you take it 3 times a day. Common side effects include making you feel dizzy and sleepy.
Summary for Antiepileptic
Prescription only
Immediate-release levetiracetam is a seizure medication for adults and children. It's known as the brand names Keppra and Roweepra, and it also has a generic version. This medication comes as a tablet and liquid that's taken twice each day. The dosage depends on your age, weight, and the type of seizure you have. Levetiracetam (Keppra) doesn't have any known interactions with food or medications. Common side effects include weakness, sleepiness, and headache.
•Might not be the best option if you have a history of mental health problems (e.g., depression, schizophrenia, bipolar disorder)
Common Side Effects of Neurontin vs. Keppra
Common Side Effects for
•Sleepiness (19%)
•Dizziness (17%)
•Poor muscle control or clumsiness (13%)
•Fatigue (11%)
Common Side Effects for
Side effects were reported by people with focal aware seizures taking levetiracetam (Keppra) with other seizure medications. Side effects might differ for other seizure types.
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Adults:
•Weakness (15%)
•Sleepiness (15%)
•Headache (14%)
•Infection (13%)
•Dizziness (9%)
Children:
•Headache (19%)
•Common cold symptoms (15%)
•Vomiting (15%)
•Sleepiness (13%)
•Tiredness (11%)
•Being aggressive (10%)
•Cough (9%)
•Stuffy nose (9%)
•Upper stomach pain (9%)
•Lower appetite (8%)
Warnings of Neurontin vs. Keppra
Common Side Effects for
•Severe allergic reactions
•Sleepiness, dizziness, and trouble concentrating
•Risk of suicidal thoughts and behavior
•Higher risk of seizures and other side effects if you stop the medication too suddenly or too fast
•Dangerously slowed breathing
•Changes in behavior in children
Common Side Effects for
•Abnormal mood, thoughts, or behavior
•Suicidal thoughts or behavior
•Difficulty with speech, movement, and concentration