Skip to main content

Compare
Neurontin vs. Perphenazine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Gabapentin (Neurontin) and Perphenazine (Trilafon) are both prescription medications, but they are used for different conditions and belong to different drug classes. Gabapentin is an antiepileptic medication used to treat certain seizures and nerve pain, while Perphenazine is a first-generation antipsychotic used to treat schizophrenia and severe nausea and vomiting. Gabapentin is available in generic form and can be taken as a tablet, capsule, or liquid, typically three times a day. In contrast, Perphenazine is also available as a generic but only in tablet form and needs to be taken multiple times a day. Gabapentin can cause dizziness and sleepiness, and it has a risk of misuse, leading some states to classify it as a controlled substance. Perphenazine, on the other hand, can cause a range of side effects, including drowsiness, dizziness, and movement problems like tardive dyskinesia. Additionally, Perphenazine carries a higher risk of death in older adults with dementia and can cause serious conditions like neuroleptic malignant syndrome. Both medications require careful monitoring by your healthcare provider to manage side effects and ensure safe use.

Gabapentin

(Neurontin)

Get free coupons

Perphenazine

 

Get free coupons

Summary for Neurontin

Prescription only

Gabapentin, also known by its brand name Neurontin, is used to treat nerve pain from shingles in adults. This medication can also help treat partial (focal) seizures in adults and children. Gabapentin (Neurontin) comes as pills and a liquid that you take by mouth. The dosage depends on things like what you're treating, how old you are, and how well the medication is working. In general, you take it 3 times a day. Common side effects include making you feel dizzy and sleepy.

Indications for Neurontin

Pros and Cons for Neurontin

Pros

  • An option for relieving nerve pain caused by shingles
  • Can take with other anti-seizure medications for partial-onset seizures in people 3 years and older
  • Available as a tablet, capsule, and liquid for those who have trouble swallowing pills

Cons

  • Usually need to taken three times per day
  • Can cause dizziness and sleepiness
  • Can cause withdrawal symptoms if you stop taking the medication too suddenly or too fast

Common Side Effects for Neurontin

  • Sleepiness (19%)
  • Dizziness (17%)
  • Poor muscle control or clumsiness (13%)
  • Fatigue (11%)

Warnings for Neurontin

  • Severe allergic reactions
  • Sleepiness, dizziness, and trouble concentrating
  • Risk of suicidal thoughts and behavior
  • Higher risk of seizures and other side effects if you stop the medication too suddenly or too fast
  • Dangerously slowed breathing
  • Changes in behavior in children

Summary for Perphenazine

Prescription only

Perphenazine is a typical antipsychotic. It's used to treat schizophrenia, as well as severe nausea and vomiting in adults. Perphenazine comes as tablets that are taken by mouth, typically up to 3 to 4 times per day, depending on the condition. Side effects of this medication include sleepiness, insomnia, and changes in body weight (both weight gain and loss); drinking alcohol can worsen certain side effects. Brand name Trilafon has been discontinued; perphenazine is only available as a generic medication.

Indications for Perphenazine

Pros and Cons for Perphenazine

Pros

  • Taken by mouth
  • Less likely to cause weight gain than some other antipsychotic medications
  • An option for severe nausea and vomiting

Cons

Common Side Effects for Perphenazine

  • Sleepiness (28%)
  • Trouble sleeping (25%)
  • Sexual side effects (25%)
  • Dry mouth (22%)
  • Constipation (22%)
  • Trouble urinating (22%)
  • Abnormal body movements (17%)
  • Weight gain (12%)
  • Changes in menstrual bleeding (11%)
  • Dizziness when standing (11%)

Warnings for Perphenazine

  • Higher risk of death in older people with dementia-related psychosis
  • Difficulty controlling body movements
  • Neuroleptic malignant syndrome (NMS)
  • Higher risk of falls
  • Lower white blood cell counts
  • Harm to unborn babies

Prices with our coupons for Neurontin vs. Perphenazine

Price Card Drug Icon
Gabapentin60 capsules / 300mg
$10.29$111.22
Get free coupons
More Information
Price Card Drug Icon
Perphenazine90 tablets / 4mg
$29.84-
Get free coupons
More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.