Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Gabapentin (Neurontin) and Perphenazine (Trilafon) are both prescription medications, but they are used for different conditions and belong to different drug classes. Gabapentin is an antiepileptic medication used to treat certain seizures and nerve pain, while Perphenazine is a first-generation antipsychotic used to treat schizophrenia and severe nausea and vomiting. Gabapentin is available in generic form and can be taken as a tablet, capsule, or liquid, typically three times a day. In contrast, Perphenazine is also available as a generic but only in tablet form and needs to be taken multiple times a day. Gabapentin can cause dizziness and sleepiness, and it has a risk of misuse, leading some states to classify it as a controlled substance. Perphenazine, on the other hand, can cause a range of side effects, including drowsiness, dizziness, and movement problems like tardive dyskinesia. Additionally, Perphenazine carries a higher risk of death in older adults with dementia and can cause serious conditions like neuroleptic malignant syndrome. Both medications require careful monitoring by your healthcare provider to manage side effects and ensure safe use.
Gabapentin (Neurontin)
Perphenazine
Gabapentin (Neurontin)
Perphenazine
Summary of Neurontin vs. Perphenazine
Summary for Antiepileptic
Prescription only
Gabapentin (Neurontin) is a medication approved to treat certain seizures and nerve pain. It's typically taken 3 times daily by mouth, and is available as pills and a liquid. Common side effects include dizziness and sleepiness.
Summary for First generation (typical) antipsychotic
Prescription only
Perphenazine is a typical antipsychotic. It's used to treat schizophrenia, as well as severe nausea and vomiting in adults. Perphenazine comes as tablets that are taken by mouth, typically up to 3 to 4 times per day, depending on the condition. Side effects of this medication include sleepiness, insomnia, and changes in body weight (both weight gain and loss); drinking alcohol can worsen certain side effects. Brand name Trilafon has been discontinued; perphenazine is only available as a generic medication.