Head-to-head comparisons of medication uses, side effects, warnings, and more.
Sunosi (solriamfetol)
Bupropion
Sunosi (solriamfetol)
Bupropion
Summary of Sunosi vs. Wellbutrin XL
Summary for Dopamine and norepinephrine reuptake inhibitor
Prescription only
Sunosi (solriamfetol) is used to improve wakefulness in adults with narcolepsy or obstructive sleep apnea. Sunosi (solriamfetol) belongs to the drug class called dopamine and norepinephrine reuptake inhibitors, and it's currently only available as a brand-name medication. Sunosi (solriamfetol) is available as tablets that are taken by mouth once daily when you first wake up. Common side effects include headache, a smaller appetite, and nausea.
Summary for Atypical antidepressant
Prescription only
Bupropion is taken by mouth to treat depression and seasonal affective disorder (SAD). It's available as short-acting tablets that are taken two or three times a day, as well as long-acting versions that are taken once daily. Bupropion has fewer sexual side effects compared to other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, or drink alcohol regularly.
•Can cause trouble sleeping if you take it later in the day
Common Side Effects of Sunosi vs. Wellbutrin XL
Common Side Effects for
•Headache (16%)
•Having a smaller appetite (9%)
•Nausea (7%)
•Anxiety (6%)
•Insomnia (trouble sleeping, 5%)
Note: Side effect percentages were reported from studies of adults with narcolepsy. These percentages might differ slightly for adults with obstructive sleep apnea.
Common Side Effects for
•Headache
•Dry mouth
•Nausea
•Trouble sleeping
•Dizziness
•Sore throat
•Constipation
•Restlessness (agitation)
Warnings of Sunosi vs. Wellbutrin XL
Common Side Effects for
•High blood pressure and fast heart rate
•Symptoms of mental health problems
Common Side Effects for
•Suicidal thoughts or behavior and abnormal mood changes
•Mental health changes
•Seizures
•High blood pressure
•Extreme enthusiasm or excitement (mania)
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