Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Clonidine ER (clonidine) and Adderall (dextroamphetamine/amphetamine salts) are both used to treat attention deficit-hyperactivity disorder (ADHD) in adults and children. However, they belong to different medication classes. Clonidine ER is an alpha-2 adrenergic agonist and is a non-stimulant, while Adderall is a stimulant medication. Clonidine ER is typically taken twice a day, whereas Adderall is taken once or twice a day, depending on the prescribed dose. Clonidine ER is available only as a generic, while Adderall is available as both a brand-name and a generic medication. Common side effects of clonidine ER include sleepiness and headache, while Adderall can cause trouble sleeping and loss of appetite. Both medications can interact with medications like tricyclic antidepressants and blood pressure medications, but Adderall can also interact with medications that affect serotonin levels. Additionally, Adderall is a controlled substance due to its potential for misuse and dependency, while clonidine ER is not.
Clonidine er (Kapvay)
Adderall
Clonidine er (Kapvay)
Adderall
Summary of Kapvay vs. Adderall
Summary for Alpha-2 adrenergic agonist
Prescription only
Extended-release clonidine (Kapvay) is an alpha-2 agonist. It's a non-stimulant medication used to treat attention deficit-hyperactivity disorder (ADHD) in adults and children. Clonidine ER (Kapvay) is taken by mouth, typically twice per day. Some of the more common side effects include sleepiness and headache. This medication rarely causes insomnia (trouble sleeping), and isn't known to cause weight gain. Brand name Kapvay has been discontinued; clonidine ER (Kapvay) is only available as a generic medication.
Summary for Stimulant
Prescription only
Adderall is a stimulant medication that's used to treat attention deficit-hyperactivity disorder (ADHD) and narcolepsy in adults and children. It contains the instant-release (IR) forms of dextroamphetamine and amphetamine salts. Adderall is available as a brand-name and lower-cost generic tablet that's taken by mouth. Your psychiatrist will adjust the dosage for you based on how well the medication works for you. Common side effects include trouble sleeping and loss of appetite.