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Amphetamine Sulfate Coupon - Amphetamine Sulfate 10mg tablet

amphetamine sulfate

Generic Evekeo
Used for Weight Loss, ADHD, Narcolepsy
Used for Weight Loss, ADHD, Narcolepsy

Amphetamine is one of the first-choice treatments that's used for attention deficit-hyperactivity disorder (ADHD). This medication has a few brand names (e.g., Evekeo, Dynavel XR, Adzenys). It's available in many dosage forms: immediate-release tablets, extended-release tablets, orally disintegrating tablets (ODTs), and oral liquids. Possible side effects include difficulty sleeping, loss of appetite, and high blood pressure. It's important to take amphetamine as prescribed to avoid overdose or withdrawal symptoms (e.g., daytime sleepiness, larger appetite, agitation).

Last reviewed on July 6, 2023
Amphetamine is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Amphetamine?

What is Amphetamine used for?

  • Attention deficit-hyperactivity disorder (ADHD) - immediate-release, extended-release, and ODTs

  • Narcolepsy (daytime sleepiness) - immediate-release tablets only

  • Short-term add-on treatment for obesity - immediate-release tablets only

How Amphetamine works

Amphetamine is a stimulant medication. It's not exactly known how amphetamine helps to improve attention and focus. But it's thought to work by raising the levels of chemicals in your brain called norepinephrine, dopamine, and serotonin.

Are you looking for information on dextroamphetamine (Dexedrine) or Adderall (amphetamine salt combo) instead?

Drug Facts

Common BrandsEvekeo, Evekeo ODT, Adzenys XR ODT, Dyanavel XR
Drug ClassStimulant
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$433.07(save 95.14%)
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$21.05
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What are the risks and warnings for Amphetamine?

Amphetamine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Misuse, addiction, and dependence

  • Risk factors: History of substance or alcohol use disorder | Taking more amphetamine than prescribed | Long-term use | Suddenly stopping amphetamine

    Amphetamine has a risk of misuse. Misusing amphetamine raises your risk for addiction and other serious side effects, such as high heart rate or blood pressure, depression, nightmares, aggressive behavior, and even thoughts of hurting yourself or others. In addition, if you take amphetamine regularly for a long period of time, you can start to rely on the medication to function normally. When you're physically dependent on the medication, you're more likely to have withdrawal symptoms, like irritability, nightmares, and sleep problems, if you suddenly stop taking the medication.

    To lower your risk of misuse, addiction, dependence, and withdrawal, take amphetamine exactly as prescribed to you. Don't change the dose or how often you take it without talking to your provider first.

    risk-warning

    Serious heart or blood flow problems

    • Risk factors: History of heart problems

      There have been reports of sudden death, stroke, and heart attack in people who took stimulants like amphetamine at normal doses. This medication can also raise your blood pressure and heart rate. Tell your provider if you have a history of heart problems before starting amphetamine to make sure it's safe for you to take. Your provider will check for heart problems before you start this medication. Tell your provider if you experience unexplained fainting, chest pain with physical activity, or irregular heartbeat while you're taking amphetamine.

      risk-warning

      Aggressive behavior and psychosis

      • Risk factors: History of psychotic episodes or other manic psychiatric conditions

        Taking a stimulant like amphetamine can cause new or worsening mental health problems such as hallucinations (seeing things that aren't really there), aggressive behavior, unclear thinking, and mania. This can sometimes happen in someone who previously didn't have any mood problems. If you develop these mood or behavior symptoms while taking amphetamine, talk to your healthcare provider right away because you might have to stop taking it.

        risk-warning

        Slow growth in children

        Stimulants like amphetamine have been linked to weight loss and a slowed growth rate (both height and weight) in children. Your child's provider will keep track of your child's growth closely to see if this becomes a problem. And if there's too much weight loss or if their growth rate is affected, the provider might pause or stop amphetamine treatment for your child. Talk to your child's provider if you notice a big amount of weight loss in your child or if you have concerns.

        risk-warning

        Seizures

        • Risk factors: History of seizures | High risk of seizures

          Although rare, stimulants like amphetamine can cause you to have seizures more easily, particularly if you've had seizures before. If this happens, seek medical help right away. You'll probably have to stop taking amphetamine.

          risk-warning

          Raynaud's phenomenon

          Amphetamine can cause a condition called Raynaud's phenomenon, which can lower blood flow to your fingers and toes. This can cause your fingers and toes to change color from pale, to blue, to red and feel cold, numb, or painful. If this happens, it's usually mild and happens occasionally. But rarely, it can cause sores to form and the tissue to become damaged. Let your provider know if you experience any of these symptoms. Usually, they get better after your provider lowers your amphetamine dose or after you stop the medication.

          risk-warning

          Serotonin syndrome

          • Risk factors: Taking monoamine oxidase inhibitors (MAOI) within 14 days of amphetamine | Taking other medications that raise serotonin levels in your brain

            Serotonin syndrome is a rare, but potentially life-threatening condition where there's too much serotonin in the brain. Serotonin is one of the chemicals in your brain responsible for your mood. Since amphetamine might raise your serotonin levels in the brain, your risk for this condition goes up if you use amphetamine with other medications that also affect serotonin levels. These medications can include antidepressants (e.g., sertraline (Zoloft), duloxetine (Cymbalta)), MAOIs (e.g., phenelzine (Nardil)), and certain migraine medications (e.g., sumatriptan (Imitrex)). Symptoms of serotonin syndrome include fast heart rate, sweating, muscle stiffness or spasms, high fever, changes in behavior, and confusion. Get medical help right away if you have any of these symptoms.

            risk-warning

            Vision problems

            Stimulants like amphetamine can cause blurred vision and other vision problems. Let your provider know if you notice any changes with your vision.

            basics-icon

            What are the side effects of Amphetamine?

            The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

            Common Side Effects

            *Side effects might differ depending on the form and brand of amphetamine you're taking. In general:

            Other Side Effects

            • Fast or irregular heartbeat
            • High blood pressure
            • Dry mouth
            • Restlessness
            • Dizziness
            • Headache
            • Change in sex drive
            • Blurry vision or other changes in vision

            Serious Side Effects

            Contact your healthcare provider immediately if you experience any of the following.
            • Allergic reactions: hives, swelling of the lips or tongue, difficulty breathing
            • Heart problems: heart attack, high blood pressure, fast heart rate
            • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
            • Mental health problems: manic episodes, psychoses
            • Seizures
            • Stroke

            Source: DailyMed

            The following side effects have also been reported

            Side effects that you should report to your care team as soon as possible:

            • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
            • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
            • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
            • Increase in blood pressure
            • Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
            • Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
            • Prolonged or painful erection
            • Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
            • Seizures
            • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

            Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

            pros-and-cons

            Pros and cons of Amphetamine

            thumbs-up

            Pros

            One of the first-choice treatments for ADHD

            Available in many dosage forms (tablets, dissolvable tablets, liquid)

            Some forms available as lower-cost generic medications

            Can be used in children

            Works within 1 hour for most people to treat symptoms of ADHD

            thumbs-down

            Cons

            Has a risk of misuse and dependence

            Is a controlled substance so there can be special requirements for filling a prescription

            Orally disintegrating tablets are only available as a brand-name medication.

            Not all forms are the same or can be substituted for one another.

            Might not be safe during pregnancy or breastfeeding

            pharmacist-tips

            Pharmacist tips for Amphetamine

            pharmacist
            • Take your first dose of amphetamine as soon as you wake up to avoid having trouble sleeping later at night.

              • Take amphetamine exactly as prescribed. Don't change your dose or stop taking the medication without talking to your provider first. Doing so can lead to bothersome withdrawal symptoms, such as daytime sleepiness, large appetite, trouble sleeping, irritation, and depression.

                • Amphetamine can be taken with or without food. But since stimulants like amphetamine tend to lower appetite (and potentially lead to weight loss), make sure to follow a healthy and balanced diet. If you or your child seems to have lost their appetite or have had concerning weight changes while taking amphetamine, let your provider know.

                  • Amphetamine can interact with other medications. These interactions can lead to more side effects. Make sure your provider knows all the medications you're taking before starting amphetamine. Don't start any new medications while taking amphetamine without talking to your provider or pharmacist first.

                    • Avoid driving the first few days after you start amphetamine and after dose changes until you know how this medication affects you. Amphetamine might cause dizziness. It might also cause blurry vision, which can affect how well you see.

                      • For the Dyanavel XR tablets: The Dyanavel XR tablets can be chewed or swallowed whole. The 5 mg tablet is scored, so it can be cut in half with a pill splitter.

                        • For the extended-release amphetamine oral suspensions (Dyanavel XR, generic): Store the amphetamine oral suspension at room temperature and keep the medication in the original bottle you got from the pharmacy. When it's time to take your medication, make sure to shake the bottle well before measuring your dose. Measure the dose using the dosing syringe or measuring cup provided by the pharmacy. Don't use household spoons or measuring cups; they're not accurate and might cause you to take the wrong dose. Contact your pharmacist or provider if you have any questions about how to measure your dose.

                          • For the orally disintegrating tablets (Adzenys XR ODT, Evekeo ODT): Keep the ODTs in the blister pack until you're ready to use them; this helps prevent the tablets from getting wet and dissolving. Use dry hands to remove them, and don't push them through the foil to avoid breaking the tablets. Place the ODT on the tongue and let the tablet dissolve without crushing or chewing it.

                            faqs

                            Frequently asked questions about Amphetamine

                            How long does amphetamine take to work?
                            Most people start to notice better concentration within 45 minutes to 1 hour of taking amphetamine. Keep in mind that how long it takes to work depends on the form and brand of the medication you're taking.
                            How long does amphetamine last?
                            The effects of the immediate-release amphetamine tablet, such as the Evekeo brand, can last about 4 to 6 hours. The effects of the extended-release (XR) forms of amphetamine can typically last longer. For example, the Dyanavel XR brand can last for 13 hours after taking it.
                            What's the difference between amphetamine and amphetamine salts?
                            Both amphetamine and amphetamine salts (e.g., Adderall) are stimulants. The main difference is that amphetamine salts contain a mixture of different types of amphetamines, one of which is amphetamine sulfate. This is why they're sometimes called "mixed amphetamines salts." On the other hand, amphetamine contains only one type of amphetamine — amphetamine sulfate. Additionally, while some forms of amphetamine and mixed amphetamine salts can be used for ADHD and narcolepsy, amphetamine is also approved for short-term treatment of obesity. Ask your provider if you have more questions about differences between the two medications.
                            Is amphetamine a controlled substance?
                            Yes, amphetamine is a schedule II controlled substance because it has a risk of misuse and dependence. These risks can lead to addiction. Misuse is when a medication is used for non-medical reasons to bring out desirable physical or emotional effects (e.g., a "high" feeling, weight loss). Sometimes, people misuse amphetamine for its effects on concentration by taking it even though it might not be prescribed for them. Dependence is when you rely on a medication to function normally and experience bothersome withdrawal symptoms if you stop taking it. Withdrawal symptoms can include depression, fatigue, high daytime sleepiness, nightmares, and a larger appetite. To help lower risks of misuse, dependence, and addiction, only take amphetamine as prescribed by your provider. Follow your provider's instructions to slowly lower the dose before completely stopping the medication. Talk to your provider if you're concerned about these risks.
                            Can I drink alcohol while taking amphetamine?
                            In general, it's best to avoid drinking alcohol while you're taking stimulants like amphetamine. Mixing alcohol with stimulant medications can worsen side effects like dizziness and affect your ability to think clearly. It's especially important not to drink alcohol while taking an extended-release form of amphetamine (e.g., Dyanavel XR, Adzenys XR ODT, amphetamine ER suspension). Drinking alcohol can cause the medication to get released into the body faster. This can cause severe side effects, including high blood pressure, fast heart rate, and aggressive behavior. Speak with your provider if you have questions about avoiding alcohol while taking amphetamine.
                            Can I use amphetamine if I'm pregnant?
                            There isn't enough information available to know if amphetamine is safe to take during pregnancy. There have been reports of premature delivery and low birth weight babies from women who were taking amphetamine. Babies born to women taking amphetamines have also suffered from withdrawal symptoms, including drowsiness, poor feeding, agitation, and irritability. If you're pregnant or thinking of getting pregnant, talk to your provider about the risks and benefits of amphetamine to you and your unborn baby. If you're currently pregnant and taking this medication, it's encouraged that you enroll in the National Pregnancy Registry for Psychiatric Medications. This pregnancy registry monitors the safety of amphetamine during pregnancy. Enroll in the program by calling 1-866-961-2388 or by visiting their website.
                            Can I breastfeed while using amphetamine?
                            It's not completely known how safe breastfeeding while taking amphetamine is because it hasn't been well studied. Because of the potential risk for side effects to babies, it's generally not recommended to breastfeed while taking amphetamine. Talk to your provider about the risks and benefits of using amphetamine while breastfeeding.
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                            dosage

                            Amphetamine dosage forms

                            The average cost for 60 tablets of 10mg of Amphetamine is $41.42 with a free GoodRx coupon. This is 90.44% off the average retail price of $433.07.
                            tablet
                            Tablet
                            DosageQuantityPrice as low asPrice per unit
                            5mg30 tablets$21.05$0.70
                            10mg60 tablets$41.42$0.69

                            Typical dosing for Amphetamine

                            Your dose will depend on what you're using amphetamine for, your age, the brand or form of amphetamine you're prescribed, and what other medications you're taking. Your provider will adjust your dose based on how well amphetamine is working for you and whether you're having side effects.

                            Immediate-release forms

                            • Tablets (generic, Evekeo brand)

                              • ADHD: For ages 3 to 5 years old, the typical starting dose is 2.5 mg by mouth once daily. For ages 6 years and older, the typical starting dose is 5 mg by mouth once or twice daily.

                              • Narcolepsy (ages 6 and older): The typical dose is 5 mg to 60 mg by mouth per day, split into multiple doses throughout the day. The first dose of the day should be taken right after waking up and then any additional doses can be taken every 4 to 6 hours.

                              • Obesity (ages 12 and older): The typical dose is up to 30 mg by mouth per day, split into multiple doses throughout the day. The medication should be taken 30 to 60 minutes before meals.

                            • Evekeo ODT brand

                              • Age 6 to 17 years old: The typical starting dose is 5 mg dissolved on the tongue once or twice daily. If needed, another dose can be given 4 to 6 hours later if your child's provider says it's okay to do so.

                            Extended-release forms

                            • Dyanavel XR brand

                              • Ages 6 years and older: The typical starting dose is 2.5 mg or 5 mg by mouth once daily in the morning. The maximum dose is 20 mg per day.

                            • Generic oral suspension

                              • Ages 6 years and older: The typical starting dose is 6.3 mg (5 mL) once daily in the morning. The maximum dose is 18.8 mg per day for children ages 6 to 12 years old and 12.5 mg per day for children ages 13 to 17 years old.

                              • Ages 18 years and older: The typical dose is 12.5 mg (10 mL) by mouth once daily.

                            • Adzenys XR ODT brand

                              • Ages 6 to 17 years old: The typical starting dose is 6.3 mg dissolved on the tongue once daily in the morning. The maximum dose is 18.8 mg per day for children ages 6 to 12 years old and 12.5 mg per day for children ages 13 to 17 years old.

                              • Ages 18 years and older: The typical dose is 12.5 mg dissolved on the tongue once daily.

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                            contraindications-icon

                            Amphetamine contraindications

                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Amphetamine will not be safe for you to take.
                            alternatives

                            What are alternatives to Amphetamine?

                            There are a number of medications that your doctor can prescribe in place of Amphetamine. Compare a few possible alternatives below.
                            Amphetamine
                            Used for:
                            • Attention deficit-hyperactivity disorder (ADHD) - immediate-release, extended-release, and ODTs

                            • Narcolepsy (daytime sleepiness) - immediate-release tablets only

                            • Short-term add-on treatment for obesity - immediate-release tablets only

                            $21.05 Lowest GoodRx priceView Prices
                            Used for:
                            • Attention-deficit hyperactivity disorder (ADHD)

                            $21.30 Lowest GoodRx priceView Prices
                            images

                            Amphetamine images

                            Blue Round 1 0 And Evk - Amphetamine Sulfate 10mg Tablet
                            This medicine is Blue, Round, Multi-Segmented Tablet Imprinted With "Evk" And "1 0".Blue Round 1 0 And Evk - Amphetamine Sulfate 10mg Tablet

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                            References

                            Best studies we found

                            American Thyroid Association. (n.d.). Hyperthyroidism.

                            Amneal Pharmaceuticals NY LLC. (2023). Amphetamine sulfate- amphetamine tablet [package insert]. DailyMed.

                            Azurity Pharmaceuticals, Inc. (2023). Evekeo ODT- amphetamine sulfate tablet, orally disintegrating [package insert]. DailyMed.

                            View All References (19)

                            Azurity Pharmaceuticals, Inc. (2023). Evekeo- amphetamine sulfate tablet [package insert]. DailyMed.

                            Centers for Disease Control and Prevention. (2020). Spoons are for soup, milliliters are for medicine.

                            Childress, A. C., et al. (2015). The efficacy and safety of Evekeo, racemic amphetamine sulfate, for treatment of attention-deficit/hyperactivity disorder symptoms: A multicenter, dose-optimized, double-blind, randomized, placebo-controlled crossover laboratory classroom study. Journal of Child and Adolescent Psychopharmacology.

                            Martin, D., et al. (2023). Amphetamine. StatPearls.

                            Massachusetts General Hospital Center for Women’s Mental Health. (n.d.). National Pregnancy Registry for Psychiatric Medications©.

                            MedlinePlus. (2023). Drug use and addiction.

                            National Institute of Neurological Disorders and Stroke. (2023). Narcolepsy.

                            National Institute on Drug Abuse. (2020). Misuse of prescription drugs research report: Overview.

                            Neos Therapeutics Brands, LLC. (2023). Adzenys XR-ODT- amphetamine tablet, orally disintegrating [package insert]. DailyMed.

                            NextWave Pharmaceuticals, Inc. (2023). Dyanavel XR- amphetamine suspension, extended release; amphetamine tablet, extended release [package insert]. DailyMed.

                            Prasco Laboratories. (2019). Amphetamine extended-release oral suspension- amphetamine suspension, extended release [package insert]. DailyMed.

                            Shoptaw, S. J., et al. (2009). Treatment for amphetamine withdrawal. The Cochrane Database of Systematic Reviews.

                            Solco Healthcare US, LLC. (2023). Amphetamine sulfate tablet [package insert]. DailyMed.

                            Takeda Pharmaceuticals America, Inc. (2023). Adderall XR- dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate capsule, extended release [package insert]. DailyMed.

                            Tris Pharma Inc. (2022). Dyanavel XR- amphetamine suspension, extended release; amphetamine tablet, extended release [package insert]. DailyMed.

                            Tris Pharma Inc. (n.d.). Frequently asked questions.

                            U.S. Food and Drug Administration. (2021). Some medicines and driving don’t mix.

                            Wolraich, M. L., et al. (2019). Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics.

                            Zorn, S. Z. (2018). The safety of stimulant medication use in cardiovascular and arrhythmia patients. American College of Cardiology.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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