Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dexmethylphenidate (Focalin, Focalin XR) and modafinil (Provigil) are both prescription medications, but they serve different purposes and belong to different drug classes. Dexmethylphenidate is a stimulant used to treat attention deficit-hyperactivity disorder (ADHD) in both adults and children. It works by increasing levels of norepinephrine and dopamine in the brain. Modafinil, on the other hand, is a wakefulness-promoting agent used to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, or shift work disorder. While both medications can cause side effects like headaches and nausea, dexmethylphenidate is a Schedule II controlled substance with a higher risk of misuse and dependence compared to modafinil, which is a Schedule IV controlled substance. Additionally, dexmethylphenidate is available in both immediate-release and extended-release forms, whereas modafinil is available in one form that's typically taken once daily. Both medications require careful monitoring by your healthcare provider due to their potential side effects and interactions with other medications.
Focalin (dexmethylphenidate)
Modafinil (Provigil)
Focalin (dexmethylphenidate)
Modafinil (Provigil)
Summary of Focalin vs. Provigil
Summary for Stimulant
Prescription only
Dexmethylphenidate (Focalin, Focalin XR) is a stimulant medication that's used for treating attention deficit-hyperactivity disorder (ADHD) in adults and children. It's thought to work by balancing certain chemicals in your brain to help you focus. This medication is available as an immediate-release tablet that you take twice per day and an extended-release capsule you take once per day. Side effects can include stomach upset and nervousness. It can also cause withdrawal symptoms if it's suddenly stopped after long-term use. Focalin (dexmethylphenidate) is available as both a brand-name and lower-cost generic medication.
Summary for Wakefulness-promoting agent
Prescription only
Modafinil (Provigil) helps improve wakefulness in adults with narcolepsy, obstructive sleep apnea, or shift work disorder. This wake-promoting medication comes as a tablet that’s taken by mouth. For adults with narcolepsy or sleep apnea, you take a dosage once daily in the morning. And for those with shift work disorder, you take your dosage 1 hour before the start of your work shift. Common side effects include headache and nausea. Modafinil (Provigil) is a controlled substance because of its potential for misuse.