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Compare Focalin vs. Vyvanse

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Focalin (dexmethylphenidate) and Vyvanse (lisdexamfetamine) are stimulant medications used to treat ADHD (attention deficit-hyperactivity disorder). Vyvanse is also FDA approved for binge-eating disorder. They’re different types of stimulants: Focalin is a methylphenidate and Vyvanse is an amphetamine. Vyvanse is an extended-release (ER) medication. Focalin comes in immediate-release (Focalin IR) and ER (Focalin XR) forms. Focalin IR may be taken twice a day while Focalin XR and Vyvanse are taken once a day usually. Focalin and Vyvanse have similar side effects such as stomach pain, low appetite, and headache. And both medications are controlled substances. This means they can lead to dependence and misuse. Taking them only as prescribed can help decrease these risks.

  • Focalin (dexmethylphenidate)
    Vyvanse (lisdexamfetamine)
  • Focalin (dexmethylphenidate)
    Vyvanse (lisdexamfetamine)

  • Summary of Focalin vs. Vyvanse

    Summary for Stimulant
    Prescription only

    Dexmethylphenidate (Focalin, Focalin XR) is a stimulant medication that's used for treating attention deficit-hyperactivity disorder (ADHD) in adults and children. It's thought to work by balancing certain chemicals in your brain to help you focus. This medication is available as an immediate-release tablet that you take twice per day and an extended-release capsule you take once per day. Side effects can include stomach upset and nervousness. It can also cause withdrawal symptoms if it's suddenly stopped after long-term use. Focalin (dexmethylphenidate) is available as both a brand-name and lower-cost generic medication.

    Summary for Stimulant
    Prescription only

    Vyvanse, the brand name for lisdexamfetamine, is a stimulant medication. It's used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It can also treat binge eating disorder (BED) in adults. Vyvanse (lisdexamfetamine) comes as capsules and chewable tablets. It's taken once per day in the morning. The dosage starts low and gets adjusted based on how you respond to the medication. Common side effects include trouble sleeping and loss of appetite. Vyvanse (lisdexamfetamine) is a controlled substance because it has a high risk of misuse and dependency.

  • Indications of Focalin vs. Vyvanse

    Indications for
    •Attention deficit-hyperactivity disorder (ADHD)
    Indications for
    •Attention deficit-hyperactivity disorder (ADHD) in people 6 years and older
    •Moderate-to-severe binge eating disorder (BED) in adults

  • Pros and Cons of Focalin vs. Vyvanse

    Pros and Const for Stimulant
    Pros
    •Works well to treat ADHD in children and adults
    •Available as immediate-release tablets and extended-release capsules for a more flexible dosing schedule
    •Available as a lower-cost generic
    Cons
    •A controlled substance because of the risk for misuse and dependency
    •Might cause trouble sleeping if you take too late in the day
    •Not the best option if you have heart problems
    •Not available as a liquid
    Pros and Const for Stimulant
    Pros
    •A first-choice ADHD medication
    •Can help with ADHD for up to 14 hours with each dose
    •For binge eating disorder, can lower the number of binge-eating days per week by about one and a half days
    •Has a few options for people who have trouble swallowing pills whole (open the capsule or switch to chewable tablets)
    Cons
    •Has a risk of misuse and dependency
    •A controlled medication, so there are special requirements for getting the prescription filled
    •Might need to take gradually lower doses before stopping to avoid withdrawal symptoms
    •Not the best choice for people with heart conditions

  • Common Side Effects of Focalin vs. Vyvanse

    Common Side Effects for

    Immediate-release tablet Age 6 to 17 years:

    •Stomach pain (15%)
    •Nausea (9%)
    •Low appetite (6%)

    Extended-release capsule Age 6 to 17 years:

    •Difficulty sleeping (up to 17%)
    •Vomiting (up to 9%)
    •Low appetite (up to 7%)

    Age 17 to 60 years:

    •Headache (up to 39%)
    •Dry mouth (up to 20%)
    •Anxiety (up to 11%)
    •Indigestion (up to 9%)
    •Throat pain (up to 7%)
    Common Side Effects for

    ADHD

    •Lower appetite (27%)
    •Trouble sleeping (27%)
    •Dry mouth (26%)

    Binge eating disorder

    •Dry mouth (36%)
    •Trouble sleeping (20%)

  • Warnings of Focalin vs. Vyvanse

    Common Side Effects for
    •Misuse and dependence
    •Serious heart problems
    •Changes in behavior or thoughts
    •Prolonged and painful erection
    •Problems with blood circulation (Raynaud's phenomenon)
    •Slowed growth in children
    •Serotonin syndrome
    •Drug interactions
    Common Side Effects for
    •Risk of misuse and addiction
    •Risks to people with serious heart problems
    •Higher blood pressure and faster heart rate
    •Strange thoughts or behavior
    •Slow growth in children
    •Problems with blood flow in the arms and legs, including Raynaud's phenomenon
    •Serotonin syndrome

  • Prices with our coupons for Focalin vs. Vyvanse

    Learn more about Focalin
    Learn more about Vyvanse

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