Key takeaways
Guanfacine ER (Intuniv) and Methylphenidate ER (Concerta) are both used to treat ADHD, but they belong to different medication classes and work differently. Guanfacine ER is an alpha-2A agonist and is not a stimulant, making it a good option for those who can't take stimulants. It's typically taken once daily at night and can take several weeks to start working. Common side effects include sleepiness and tiredness. On the other hand, Methylphenidate ER is a stimulant and is considered a first-choice medication for ADHD. It starts working within 2 hours and lasts throughout the day, but it can cause difficulty sleeping and loss of appetite. Methylphenidate ER has a risk of misuse and dependency, making it a controlled substance, whereas Guanfacine ER is not. Additionally, Methylphenidate ER is available in various forms, including tablets, capsules, and liquids, while Guanfacine ER is only available as a tablet.
