Key takeaways
Guanfacine ER (Intuniv) and guanfacine (Tenex) are both medications that affect alpha-2 receptors in the brain, but they are used for different conditions. Guanfacine ER (Intuniv) is an extended-release medication approved to treat ADHD in children ages 6 to 17, while guanfacine (Tenex) is an immediate-release medication used to treat high blood pressure in people 12 years and older. Guanfacine ER is taken once daily and is not a stimulant, making it a good option for those who can't take stimulant-based ADHD medications. On the other hand, guanfacine is typically taken at night to help manage its common side effects like sleepiness and dizziness. Both medications are available as lower-cost generics, but they should not be used interchangeably. Guanfacine ER is not approved for adults with ADHD, and guanfacine is not a first-choice option for high blood pressure.
