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Compare Rexulti vs. Wellbutrin XL

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Brexpiprazole (Rexulti)
    Bupropion
  • Brexpiprazole (Rexulti)
    Bupropion

  • Summary of Rexulti vs. Wellbutrin XL

    Summary for Atypical Antipsychotic
    Prescription only

    Brexpiprazole (Rexulti) is an atypical antipsychotic medication approved to treat depression (add-on medication) and schizophrenia. Brand name Rexulti can also treat dementia-related agitation from Alzheimer's disease. Brexpiprazole (Rexulti) is taken by mouth, typically once daily. Some of its more common side effects of brexpiprazole (Rexulti) include restlessness, moderate weight gain, and headaches. It's available as a generic medication.

    Summary for Atypical antidepressant
    Prescription only

    Bupropion is taken by mouth to treat depression and seasonal affective disorder (SAD). It's available as short-acting tablets that are taken two or three times a day, as well as long-acting versions that are taken once daily. Bupropion has fewer sexual side effects compared to other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, or drink alcohol regularly.

  • Indications of Rexulti vs. Wellbutrin XL

    Indications for
    •Schizophrenia
    •Add-on treatment for depression
    •Dementia-related agitation from Alzheimer's disease
    Indications for
    •Depression
    •Seasonal affective disorder (SAD) - only bupropion HCl extended-release (Wellbutrin XL)

  • Pros and Cons of Rexulti vs. Wellbutrin XL

    Pros and Const for Atypical Antipsychotic
    Pros
    •Only need to take the medication once a day
    •Less likely to cause weight gain, high cholesterol, or high blood sugar compared with other similar medications
    •Less likely to cause movement side effects compared to some other antipsychotics
    Cons
    •Can be expensive because it's only available as a brand-name medication
    •Not recommended for use in pregnancy
    •Your healthcare provider might need to adjust your dose several times before you find one that works best for you
    Pros and Const for Atypical antidepressant
    Pros
    •Works well for depression and can be used alone or in combination with other antidepressants
    •Causes fewer sexual side effects than some other antidepressants
    •Available in a lower-cost generic form
    •Less likely to cause weight gain compared to other antidepressants
    •Good option for people who haven't had success with traditional antidepressants like selective serotonin reuptake inhibitors (SSRIs)
    Cons
    •Can take several weeks to feel the full effects
    •Not the best option if you have a history of seizures or eating disorders like as anorexia or bulimia
    •Might need to limit or avoid using alcohol during treatment
    •Can cause trouble sleeping if you take it later in the day

  • Common Side Effects of Rexulti vs. Wellbutrin XL

    Common Side Effects for
    •Fidgeting (9%)
    •Weight gain (7%)
    •Headache (7%)
    •Sleepiness (5%)
    •Tremor (4%)
    •Common cold (4%)
    •Larger appetite (3%)
    •Fatigue (3%)
    •Dizziness (3%)
    •Restlessness (3%)
    •Anxiety (3%)
    •Heartburn (3%)
    •Diarrhea (3%)
    •Constipation (2%)
    Common Side Effects for
    •Headache
    •Dry mouth
    •Nausea
    •Trouble sleeping
    •Dizziness
    •Sore throat
    •Constipation
    •Restlessness (agitation)

  • Warnings of Rexulti vs. Wellbutrin XL

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Suicidal thoughts and behavior
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Impulsive behavior
    •Higher risk of infections
    •Higher risk of falls
    •Seizures
    Common Side Effects for
    •Suicidal thoughts or behavior and abnormal mood changes
    •Mental health changes
    •Seizures
    •High blood pressure
    •Extreme enthusiasm or excitement (mania)

  • Prices with our coupons for Rexulti vs. Wellbutrin XL

    Learn more about Brexpiprazole
    Learn more about Bupropion

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