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Chlorpromazine vs. Risperdal

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Chlorpromazine (generic name) and Risperdal (generic name: risperidone) are both antipsychotic medications, but they belong to different classes. Chlorpromazine is a first-generation (typical) antipsychotic, while Risperdal is an atypical antipsychotic. Chlorpromazine is used for a wide range of conditions, including schizophrenia, bipolar disorder, severe behavioral issues in children, and even persistent hiccups. In contrast, Risperdal is primarily used for schizophrenia, bipolar disorder, and irritability associated with autism. Chlorpromazine is available in both oral and injectable forms, whereas Risperdal is also available in oral and injectable forms. Chlorpromazine often needs to be taken multiple times a day, while Risperdal is typically taken once or twice daily. Both medications can cause weight gain and drowsiness, sexual problems and changes in sleep patterns. Additionally, both medications carry a risk of serious side effects like neuroleptic malignant syndrome and tardive dyskinesia, and they should not be used in older adults with dementia-related psychosis due to a higher risk of death.

Chlorpromazine

 

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Risperidone

(Risperdal)

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Summary for Chlorpromazine

Prescription only

Chlorpromazine is an antipsychotic medication used to treat many conditions that affect the brain and nervous system, including schizophrenia, bipolar disorder, and ongoing hiccups. It works by blocking certain chemicals in the body, like histamine and dopamine. Your dose depends on why you’re taking it and how severe your symptoms are, but it’s usually taken three or four times a day. Common side effects include drowsiness and movement problems.

Indications for Chlorpromazine

Pros and Cons for Chlorpromazine

Pros

  • Approved to treat several conditions
  • Starts working quickly
  • Available as a tablet, liquid, and injection
  • Dose can be easily adjusted based on your symptoms

Cons

  • Needs to be taken multiple times a day
  • Commonly causes drowsiness
  • Risk of uncontrolled muscle movements
  • Not recommended for use in pregnancy

Common Side Effects for Chlorpromazine

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urination problems

Warnings for Chlorpromazine

  • Higher risk of death in older adults with dementia
  • Uncontrolled muscle movements
  • Neuroleptic malignant syndrome
  • Changes in blood cell counts
  • High prolactin levels
  • Falls and fractures

Summary for Risperdal

Prescription only

Risperidone (Risperdal) is an atypical antipsychotic that's used to improve mood, thoughts, and behaviors in people with schizophrenia, bipolar disorder, and autism. It's taken by mouth, typically once or twice daily. Common side effects of risperidone (Risperdal) include sleepiness, movement problems, and weight gain. Risperidone (Risperdal) can interact with some medications, such as certain antidepressants or blood pressure medications. Taking these medications together can make certain side effects worse.

Indications for Risperdal

  • Schizophrenia - people ages 13 years and older
  • Manic or mixed episodes associated with bipolar I disorder - people ages 10 years and older
  • Irritability associated with autism - children ages 5 to 17 years old

Pros and Cons for Risperdal

Pros

  • Taken by mouth
  • Available as a pill, dissolving tablet, and liquid
  • Can be used in both adults and children
  • Available as a lower-cost generic

Cons

  • Higher risk of sexual problems, compared to other atypical antipsychotics
  • Can cause weight gain
  • Can cause changes to sleep or movement problems
  • Shouldn't be mixed with alcohol

Common Side Effects for Risperdal

Adults:

  • Muscle stiffness, muscle tightening, difficulty with movement (25%)
  • Extreme sleepiness (11%)
  • Restlessness, trouble remaining still (9%)
  • Tremor (6%)
  • Dizziness (6%)
  • Nausea (5%)
  • Repetitive movements, abnormal postures (5%)

Children:

  • Extreme sleepiness (up to 56%)
  • Dizziness (up to 16%)
  • Nausea or vomiting (up to 16%)
  • Stomach pain (up to 16%)
  • Muscle stiffness, muscle tightening, difficulty with movement (up to 12%)
  • Heartburn (up to 10%)
  • Sore throat (up to 10%)

Warnings for Risperdal

  • Higher risk of death in older adults with dementia-related psychosis
  • Neuroleptic malignant syndrome
  • Difficulty controlling muscle movements (tardive dyskinesia)
  • Weight gain, higher blood sugar, and higher cholesterol levels
  • High prolactin levels
  • Changes in blood pressure and higher risk of falls
  • Risk of infection (from low white blood cell count)
  • Difficulty concentrating and extreme sleepiness
  • Seizures
  • Prolonged and painful erection
  • Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

Prices with our coupons for Chlorpromazine vs. Risperdal

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Chlorpromazine30 tablets / 25mg
$23.18$332.96
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Risperidone30 tablets / 1mg
$9.00$9.00
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