Key takeaways
Haloperidol (Haldol) and perphenazine (Trilafon) are both typical antipsychotics used to treat schizophrenia, but they have some key differences. Haloperidol is available as oral forms, and an injection, either long-acting (given monthly) or short-acting (used in hospital settings), while perphenazine is taken orally multiple times a day. Haloperidol and perphenazine primarily work by blocking dopamine activity to reduce hallucinations and delusions. Perphenazine is unique in that it is also approved to treat severe nausea and vomiting, unlike haloperidol. Both medications can cause movement-related side effects, weight gain and other side effects like drowsiness and dizziness. Both medications carry serious risks for older adults with dementia-related psychosis, including a higher risk of death and stroke.
