Key takeaways
Loxapine (Loxitane) and trifluoperazine (Stelazine) are both typical antipsychotics used to treat schizophrenia. They both affect dopamine levels in the brain to help manage symptoms like hallucinations and delusions. However, trifluoperazine is also FDA-approved for treating anxiety, while loxapine is not. Loxapine is typically taken once or twice daily, with usual doses ranging from 20 mg to 100 mg. Trifluoperazine is taken twice daily, with doses for schizophrenia starting at 2 mg to 5 mg, and for anxiety at 1 mg to 2 mg, with a maximum of 6 mg per day. Both medications can cause movement-related side effects, but trifluoperazine is not recommended for long-term use due to a high risk of movement problems. Both medications can cause drowsiness and dizziness and should be used cautiously in older adults, especially those with dementia-related psychosis, due to an increased risk of death.
