provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Loxapine Coupon - Loxapine 10mg capsule

loxapine

Generic Loxitane
Used for Schizophrenia
Used for Schizophrenia

Loxapine is a typical antipsychotic used to treat schizophrenia. Loxapine is taken by mouth, typically once or twice daily. It can cause more movement-related side effects compared with atypical antipsychotics, such as aripiprazole (Abilify). It used to be sold under the brand name Loxitane, which is no longer available. Oral loxapine is now only available as generic capsules.

Last reviewed on May 10, 2023
basics-icon

What is Loxapine?

What is Loxapine used for?

  • Schizophrenia

How Loxapine works

Loxapine is an antipsychotic medication. It's not exactly clear how loxapine works, but it's thought to regulate dopamine and serotonin levels in your brain. Dopamine and serotonin are natural chemicals that affect your thoughts and mood. Imbalances in these chemical levels might cause symptoms of schizophrenia, such as seeing things that aren't there (hallucinations) and believing things that aren't real (delusions).

Are you looking for information on Adasuve (loxapine) inhaler instead?

Drug Facts

Common BrandsLoxitane (brand name no longer available)
Drug ClassFirst-generation (typical) antipsychotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$72.97(save 73.07%)
GoodRx discount
$19.65
See prices
basics-icon

What are the side effects of Loxapine?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Extrapyramidal symptoms (movement problems, such as shakiness, stiffness, excess saliva, and loss of facial expression)
  • Restless muscles (akathisia)

Other Side Effects

  • Dizziness
  • Feeling faint
  • Sleepiness or trouble sleeping
  • Confusion
  • Trouble swallowing or breathing
  • Agitation (distress)
  • Slurred speech
  • Hair loss
  • Dry mouth
  • Nausea

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Neuroleptic malignant syndrome (NMS): high fever, muscle stiffness, confusion, sweating, changes in pulse, heart rate, and blood pressure
  • Uncontrollable muscle movements of the face, tongue, or other body parts: sticking out your tongue, puffing out your cheeks, puckering your mouth, lip smacking, chewing, shaking in your arms and legs
  • Serious infection (from low blood cell count): fever, weakness, fatigue, sore throat, cough, body aches, chills
  • Seizures

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Difficulty with speaking or swallowing

lip smacking or puckering

loss of balance control

mask-like face

puffing of the cheeks

rapid or fine, worm-like movements of the tongue

restlessness or desire to keep moving

shuffling walk

slowed movements

stiffness of the arms and legs

trembling and shaking of the fingers and hands

uncontrolled chewing movements

uncontrolled movements of the arms or legs

Less common

Constipation (severe)

difficult urination

inability to move the eyes

muscle spasms, especially of the neck and back

skin rash

twisting movements of the body

Rare

Difficult or fast breathing

fast heartbeat or irregular pulse

fever (high)

high or low blood pressure

increased blinking or spasms of the eyelid

increased sweating

loss of bladder control

muscle stiffness (severe)

seizures

sore throat and fever

uncontrolled twisting movements of the neck, trunk, arms, or legs

unusual bleeding or bruising

unusual facial expressions or body positions

unusual tiredness or weakness

unusually pale skin

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position

drowsiness (severe)

irregular, fast or slow, or shallow breathing

loss of consciousness

muscle trembling, jerking, stiffness, or uncontrolled movements (severe)

pale or blue lips, fingernails, or skin

troubled breathing (severe)

unusual tiredness or weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision

confusion

dizziness, lightheadedness, or fainting

drowsiness

dryness of the mouth

Less common

Constipation (mild)

decreased sexual ability

enlargement of the breasts (males and females)

headache

increased sensitivity of the skin to sunlight

missing menstrual periods

nausea or vomiting

trouble with sleeping

unusual secretion of milk

weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Loxapine

thumbs-up

Pros

A good option if other schizophrenia medications haven't worked or have caused bothersome side effects

Dose can be adjusted by your provider based on your response

Available as a lower-cost generic medication

thumbs-down

Cons

More likely to cause trouble controlling movements compared to other treatment options

Can raise your heart rate and lower your blood pressure

Risk of developing abnormal muscle movements that might not go away after you stop taking loxapine

pharmacist-tips

Pharmacist tips for Loxapine

pharmacist
  • Loxapine can cause drowsiness, sleepiness, and dizziness. Don't drive or do anything that requires concentration until you know how loxapine affects you.

    • Loxapine can cause your blood pressure to drop when you change positions. This can cause falls and fainting. Be very careful when you stand after sitting or lying down.

      • Antipsychotic medications can cause abnormal muscle movements called tardive dyskinesia. Usually, this problem goes away when you stop the medication, but there's a chance it might not. Let your healthcare provider know if you start having muscle twitches, smacking your lips, sticking your tongue out, or having trouble controlling your face or mouth.

        faqs

        Frequently asked questions about Loxapine

        How long does it take loxapine to work?
        You might start to feel the calming effects of loxapine within 20 to 30 minutes, but it can take longer to feel the full effects. Keep in mind that when you're starting loxapine for the first time, it might take some time before you and your provider find the right dose of the medication that works best for you. Talk with your provider if you're not sure whether this medication is working for you.
        Does loxapine cause weight gain?
        Weight gain and weight loss have both been reported by people who've taken loxapine, but it's unclear if the medication has a definitive effect on weight. If weight gain is a concern, talk to your provider before starting loxapine.
        Does loxapine make you sleepy?
        Loxapine can cause drowsiness, but it's usually mild and typically only occur when you first start the medication or when your provider raises your dose. Sleepiness generally starts within 20 to 30 minutes after taking the medication, is strongest within around 1.5 to 3 hours, and can last up to 12 hours. Let your provider know if you feel very drowsy and they can check to see if they need to adjust your dose of loxapine.
        Can loxapine make you anxious?
        Some people did report feeling more agitated while taking loxapine, but it's not a common side effect. In general, this medication is sedating, which means it helps calm you down or make you more sleepy. In fact, people do report feeling drowsy when they first starting loxapine for the first time or whenever their provider raises their dose. If you feel more anxious after starting loxapine, contact your healthcare provider.
        Is it safe to drink alcohol while taking loxapine?
        Drinking alcohol isn't recommended while you're taking loxapine. Combining loxapine with alcohol might not only worsen your health condition, but might also worsen side effects like drowsiness, problems with coordination, and trouble thinking clearly.
        Is it safe to take loxapine while pregnant?
        If you're pregnant or thinking of becoming pregnant, tell your provider before starting loxapine. This medication hasn't been well-studied in human pregnancy. But taking antipsychotics, including loxapine, during the third trimester of pregnancy can be harmful to your baby. Your baby might be born with movement disorders or withdrawal symptoms, such as agitation, stiff or limp muscles, shakiness, sleepiness, high-pitched crying, and poor feeding.
        Is loxapine available as an inhaler?
        Yes, loxapine is available as an inhaler called Adasuve. Adasuve is only used to treat agitation related to schizophrenia and bipolar I disorder and it has to be given by a healthcare provider.
        GoodRxEducationalIcon

        How to save using GoodRx

        Compare Prices
        1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
        Select your free coupon
        2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
        Show coupon to your pharmacist
        3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
        Get free couponLearn more
        warings-icon

        What are the risks and warnings for Loxapine?

        Loxapine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

        risk-warning

        Higher risk of death in older adults

        • Risk factors: Older adults with dementia-related psychosis

          People over the age of 65 who also have dementia sometimes have some schizophrenia-like symptoms, such as hallucinations. Older people with dementia-related psychosis have a higher risk of death if they take medications like loxapine. Because of this risk, loxapine shouldn't be used in people 65 years and older with dementia-related psychosis. Let your provider know if you or your loved one has dementia before starting loxapine.

          risk-warning

          Uncontrollable body movements (tardive dyskinesia)

          • Risk factors: Long-term use | Taking high doses of loxapine or other antipsychotics | Older age | Female and 65 years or older

            Loxapine, like all antipsychotics, can cause uncontrollable movements (tardive dyskinesia) involving your face, tongue, and other body parts. Symptoms include shaking, muscle stiffness, or feeling like you can't sit still. This condition might go away once you stop the medication, but there's a chance it can become permanent. The risk is greatest if you've been taking loxapine for a long time or have been taking high doses, but it can also occur at any point during treatment or at any dose. Tell your provider right away if you notice any unusual movements.

            risk-warning

            Neuroleptic malignant syndrome

            Loxapine can cause a rare but life-threatening condition called neuroleptic malignant syndrome (NMS). Symptoms of NMS include high fever, muscle stiffness, confusion, sweating, and changes in heart rate and blood pressure. If you notice any of these symptoms, get medical help right away.

            risk-warning

            Falls

            • Risk factors: Conditions or taking medications that make you dizzy or less alert

              Loxapine can cause a sudden drop in blood pressure, sleepiness, and problems with balance. Dizziness, falls, and fainting can happen due to a sudden drop in blood pressure when you change positions, such as going from sitting to standing. To avoid falling, change positions slowly until your body is used to the medication.

              risk-warning

              Low white blood cell count

              • Risk factors: History of low white blood cell count

                Loxapine can lower the amount of white blood cells (WBCs) in your body. WBCs help your body fight off infections and diseases. Having fewer WBCs means you're more likely to get sick. If you notice a fever or that you're getting sick more easily, let your provider know right away. Blood tests might be done before you start loxapine and during the first few months of taking this medication to make sure that you have a healthy amount of white blood cells. If the amount of white blood cells in your body is too low, you'll need to stop the medication.

                risk-warning

                Seizures

                • Risk factors: History of seizures | Conditions that make it easier to have seizures

                  Loxapine can make you more likely to have seizures, especially if you have a history of seizures or have conditions that make it easier to have a seizure. Let your provider know if you've had seizures in the past before starting the medication, so your provider can monitor you more closely.

                  risk-warning

                  Vision changes

                  • Risk factors: Long-term use

                    Loxapine can cause vision changes, especially if it's taken for a long time. Let your provider know right away if you notice any changes in your vision.

                    risk-warning

                    High prolactin levels

                    Loxapine can cause the prolactin levels in your blood to go up. Prolactin is a hormone in your body that affects lactation and the reproductive system. High prolactin levels can lead to milky nipple discharge, enlarged male breasts, sexual dysfunction, absent or irregular menstrual periods, and weak bones. Let your provider know if you experience these symptoms.

                    dosage

                    Loxapine dosage forms

                    The average cost for 60 capsules of 10mg of Loxapine is $25.46 with a free GoodRx coupon. This is 65.11% off the average retail price of $72.97.
                    capsule
                    Capsule
                    DosageQuantityPrice as low asPrice per unit
                    5mg60 capsules$23.70$0.39
                    10mg60 capsules$25.46$0.42
                    25mg30 capsules$19.65$0.65
                    50mg60 capsules$47.37$0.79

                    Typical dosing for Loxapine

                    The dose depends on how severe your symptoms are and how you've responded to other medications for schizophrenia in the past.

                    In general, the typical starting dose is 10 mg by mouth twice a day. Your healthcare provider will raise your dose rather quickly over the first 7 to 10 days until your symptoms of schizophrenia are controlled. The typical maintenance dose ranges from 20 mg to 100 mg daily. The maximum daily dose is 250 mg.

                    interactions

                    Interactions between Loxapine and other drugs

                    Loxapine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Loxapine. Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    • Betel Nut
                    drug-cost

                    How much does Loxapine cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                    contraindications-icon

                    Loxapine contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Loxapine will not be safe for you to take.
                    • In a coma or sedated state caused by alcohol or medications

                    • Allergy to loxapine or amoxapine

                    alternatives

                    What are alternatives to Loxapine?

                    There are a number of medications that your doctor can prescribe in place of Loxapine. Compare a few possible alternatives below.
                    Loxapine
                    Used for:
                    • Schizophrenia

                    $19.65 Lowest GoodRx priceView Prices
                    Used for:
                    • Psychotic and behavioral disorders

                    • Tourette syndrome in adults and children

                    • Hyperactivity in children

                    $12.94 Lowest GoodRx priceView Prices
                    Used for:
                    • Management of psychotic disorders

                    • Schizophrenia

                    • Nausea and vomiting

                    • Restlessness and anxiety before surgery

                    • Acute intermittent porphyria

                    • Tetanus

                    • Manic episodes of bipolar disorder

                    • Hiccups that won't go away

                    • Severe behavioral issues in children 1 to 12 years old (e.g., aggressive behavior, frustration, explosive or hyperexcitable behavior)

                    $37.40 Lowest GoodRx priceView Prices
                    images

                    Loxapine images

                    Green And Yellow Mylan 7010 Mylan 7010 - Loxapine Succinate 10mg Capsule
                    This medicine is Green And Yellow Capsule Imprinted With "Mylan 7010 Mylan 7010".Green And Yellow Mylan 7010 Mylan 7010 - Loxapine Succinate 10mg Capsule
                    Yellow And Green Logo Lannett 1395 - Loxapine Succinate 10mg Capsule
                    This medicine is Yellow And Green Capsule Imprinted With "Logo Lannett 1395".Yellow And Green Logo Lannett 1395 - Loxapine Succinate 10mg Capsule
                    White And Yellow Watson 370 10 Mg - Loxapine Succinate 10mg Capsule
                    This medicine is White And Yellow Capsule Imprinted With "Watson 370 10 Mg".White And Yellow Watson 370 10 Mg - Loxapine Succinate 10mg Capsule
                    Green And Yellow E526 E526 - Loxapine Succinate 10mg Capsule
                    This medicine is Green And Yellow Capsule Imprinted With "E526 E526".Green And Yellow E526 E526 - Loxapine Succinate 10mg Capsule

                    Get savings updates for Loxapine

                    Receive price alerts, news, and other messages from GoodRx about Loxapine and other healthcare topics and relevant savings offers.

                    By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                    References

                    Best studies we found

                    American Heart Association. (2023). Low blood pressure - when blood pressure is too low.

                    Chartwell RX, LLC. (2023). Loxapine capsule [package insert]. DailyMed.

                    Patel, K. R., et al. (2014). Schizophrenia: Overview and treatment options. Pharmacy and Therapeutics.

                    View All References (2)

                    Singh, A. N., et al. (2003). Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia. Journal of Psychiatry & Neuroscience.

                    Vanina, Y., et al. (2002). Body weight changes associated with psychopharmacology. Psychiatric Services.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                    Was this page helpful?

                    Browse medications

                    View All

                    Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.